The objective of this paper is to apply the Taguchi method with fuzzy inference for optimization the design of an ultrathin centrifugal fan with multiple performance characteristics. The weight of fuzzy rule controlling the system can be adjusted in this study. Taguchi’s concepts of orthogonal array, signal to noise (S/N) ratio, ANOVA, and weight of fuzzy rule were used to study the multiple-objectives in the ultrathin centrifugal fan design. The results showed that: (1) the inlet dimensions have a significant influence on the volume flow rate, whereas outlet dimensions, inlet dimensions and blade angle have a significant effect on the static pressure; (2) appropriate adjustments the weight of fuzzy rule can be obtained a better design parameters for the objective.