Objective: Technology-based remote communication offers unique opportunities regarding healthcare, and telenutrition provides ambulatory nutrition care equal to or even superior to in-person care. This study aimed to explore the effectiveness of different methods used in the telenutrition system in weight loss targeted processes. Material and Methods: Three different intervention methods were examined: interaction group (n=34), monitoring group (n=34), and mail group (n=34). Hundred and two women clients with a body mass index between 18.5 and 25 kg/m2 were monitored for 8 weeks. Each participant conveyed the weekly weight measurements result before eating in the morning. The data were evaluated by SPSS 25.0 software, and the results were considered statistically significant for p<0.05. Results: The highest mean weight loss was observed among participants in the interaction group, and they experienced significantly higher weight loss than those in the mail group. The body mass index changes were more significant among clients in the interaction group with a mean of 2.2±0.4 kg/m2, followed by the monitoring group; 1.9±0.4 kg/m2, and the lowest change was observed in the mail group; 0.9±0.7 kg/m2. Additionally, participants in the interaction group experienced the highest body mass index decrease compared to the monitoring and mail groups (p<0.001). Conclusion: In conclusion, it should be indicated that increased interaction between client and dietitian and within clients may increase the weight loss success. More comprehensive studies evaluating telenutrition counseling with follow-ups and group interventions are required to investigate the exact effects of virtual counseling on weight loss management with a large population.