Weight Loss In Adolescents Research Articles

Are exercise prescriptions an effective intervention for weight loss in adults and adolescents?

Air Force/UNMC Family Medicine Residency, Bellevue, NE The corresponding author is LaTraia Scott; [email protected]. The authors declare no conflict of interest. The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the US Air Force Medical Department, the Air Force at large, or the Department of Defense.

The Relationship between Metabolic Comorbidities and Post-Surgical Weight Loss Outcomes in Adolescents Undergoing Laparoscopic Sleeve Gastrectomy

Introduction: Little is known about the relationship between metabolic factors and weight loss success in adolescents undergoing bariatric surgery. Methods: The objective of this study was to assess if baseline metabolic characteristics associate with weight loss in adolescents undergoing laparoscopic sleeve gastrectomy. A retrospective study was conducted in a comprehensive adolescent bariatric surgery center of 151 subjects (34 male, 117 female). Anthropometric measurements and metabolic factors including blood pressure, fasting glucose, hemoglobin A1c (HbA1c), metabolic syndrome (MeS), liver function, triglycerides, and waist circumference were collected at one pre-surgical visit and at 6- and/or 12-month post-laparoscopic sleeve gastrectomy. Weight loss was compared between subjects with normal or abnormal baseline metabolic factors. Absolute BMI change was used to measure successful weight loss. Results: Higher baseline systolic blood pressure (SBP) was associated with greater weight loss as measured by body mass index (BMI) change and BMI standard deviation score (BMI-SDS) change at 6 and 12 months. Those patients in the 6-month follow-up group with an abnormal HbA1c at baseline had significantly more weight loss as measured by BMI-SDS. None of the other parameters, including fasting glucose, MeS, liver function, triglycerides, and waist circumference showed a predictive relationship. Conclusion: Elevated SBP and HbA1c in adolescents with morbid obesity may reflect a population more likely to achieve successful weight loss and, thus, may be a good target for bariatric surgery, specifically laparoscopic sleeve gastrectomy, as an intervention for severe obesity. An assessment of behavioral differences in patients with and without elevated BP and HbA1c might explain the mechanism for the improved weight loss.

Body weight training intervention towards weight loss of adolescent with obesity problem during COVID-19 pandemic

The COVID-19 pandemic has brought attention to the rising issue of sedentary behavior, which can lead to obesity. Obesity affects individuals of all ages, including children, adults, and the elderly. Obesity can have negative effects on adolescent body image. Several interventions, such as body weight training, have been shown to help obese adolescents lose weight. This paper proposes an investigation into the effectiveness of body weight training interventions as implemented by community nurses for weight loss in obese adolescents. The intervention involved three sessions per week over the course of four weeks and was administered to several obese adolescents. The results indicated that there was a weight loss of 3.7 kg for the first participant and 3.8 kg for the second participant over the four-week period. Statistical analysis using a paired t-test showed a p-value less than 0.005, indicating a significant effect of the body weight training intervention on weight loss in obese adolescents. It is hoped that community nurses can utilize body weight training as a useful intervention in helping obese adolescents achieve a healthy weight.

Factors affecting the use of herbal medicines for weight loss in overweight and obese adolescents.

Herbal medicine (HM) is widely used to treat obesity in adolescents worldwide since the currently available interventions have low compliance and lack long-term effects and safety data. This study aimed to analyze the factors affecting HM use for weight loss in overweight and obese adolescents. A total of 46,336 adolescents were included in this cross-sectional study based on the Korea Youth Risk Behavior Web-Based Survey. Three models of HM use for weigh loss were developed by sequentially adding predisposing, enabling, and need factors according to Andersen's model using multiple logistic regression analyses considering the complex sampling design. Male and female high school students and students from low perceived household economic status were less likely to use HM for weight loss. Students whose fathers had a college degree or higher, depressed mood, and two or more chronic allergic diseases were more likely to use HM. Male students who perceived their body image as fat or very fat tended to use HM less than those who perceived their body image as very thin, thin, or moderate. Obese female students tended to use HM more than overweight female students. These results can be used as the bases to promote HM use, provide ideas for future research, and strengthen the health insurance coverage extension for weight loss interventions.

Improving Access to Child and Adolescent Weight Loss Surgery: A Review of Updated National and International Practice Guidelines.

The rise of childhood obesity is a growing concern due to its negative impact on health.Metabolic bariatric surgery (MBS) has gained popularity as an effective and adequate intervention for children and adolescent patients living with severe obesity. Nonetheless, access to MBS for this population is still limited. The objective of this paper is to conduct a comprehensive review of the latest national and international practice guidelines and improve access to MBS for children and adolescents. The paper focuses on the recommendations from the 2023 American Academy of Pediatrics (AAP) and 2022 guidelines from the American Society for Metabolic and Bariatric Surgery (ASMBS) and the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO). Recently updated guidelines from the ASMBS and IFSO aim to improve access to MBS for children and adolescents and recommend patient selection, preoperative evaluation, and postoperative care. While lifestyle changes, medication, and behavioral therapy are commonly prescribed, they often fail to achieve permanent weight loss and its maintenance. Weight-loss surgeries like sleeve gastrectomy (SG) and gastric bypass (RYGB) show promising results in managing severe obesity in adolescents. SG has become the preferred method for treating severe obesity in adolescents, surpassing RYGB. Weight stigma is also explored in this review, revealing its negative effects on individuals who are overweight and underweight. Furthermore, telehealth is identified as an increasingly valuable tool for managing pediatric obesity, as it can improve access to care, particularly for those in remote areas where physicians trained to treat childhood obesity and the shortage of bariatric surgeons experienced in treating younger adolescents and pediatricians with advanced training are major obstacles.

A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity.

Hypothalamic obesity is a rare, treatment-resistant form of obesity. In preliminary studies, the hypothalamic hormone oxytocin (OXT) has shown promise as a potential weight loss therapy. To determine whether 8 weeks of intranasal OXT (vs 8 weeks of placebo) promotes weight loss in children, adolescents, and young adults with hypothalamic obesity. This randomized, double-blind, placebo-controlled, crossover pilot trial (NCT02849743), conducted at an outpatient academic medical center, included patients aged 10 to 35 years with hypothalamic obesity from hypothalamic/pituitary tumors. Participants received intranasal OXT (Syntocinon, 40 USP units/mL, 4 IU/spray) vs excipient-matched placebo, 16 to 24 IU 3 times daily at mealtimes. Weight loss attributable to OXT vs placebo and safety (adverse events) were assessed. Of 13 individuals randomized (54% female, 31% pre-pubertal, median age 15.3 years, IQR 13.3-20.6), 10 completed the entire study. We observed a nonsignificant within-subject weight change of -0.6 kg (95% CI: -2.7, 1.5) attributable to OXT vs placebo. A subset (2/18 screened, 5/13 randomized) had prolonged QTc interval on electrocardiography prior to screening and/or in both treatment conditions. Overall, OXT was well-tolerated, and adverse events (epistaxis and nasal irritation, headache, nausea/vomiting, and changes in heart rate, blood pressure, and QTc interval) were similar between OXT and placebo. In exploratory analyses, benefits of OXT for anxiety and impulsivity were observed. In this pilot study in hypothalamic obesity, we did not detect a significant impact of intranasal OXT on body weight. OXT was well-tolerated, so future larger studies could examine different dosing, combination therapies, and potential psychosocial benefits.

MANAGEMENT OF WALKING PHYSICAL ACTIVITY IN ADOLESCENTS WITH OBESITY IN RT 07 RW 016 SRENGSENG SAWAH, JAGAKARSA, SOUTH JAKARTA

Introduction: Obesity is one of the health problems that must be handled properly because it can affect individuals of all ages, from children to adults. Obesity occurs in school-age children because it can interfere with the health and body image of the child. Some interventions are believed to help lose weight in school-age children who are obese. Self Hypnosis therapy is one intervention that has been proven to be able to lose weight. The application of nursing care aims to determine the effectiveness of Self Hypnosis therapy on weight loss in school-age children who are obese.
 Method: Obesity is one of the most common nutritional health problems in children and adolescents. Obesity is a serious problem and requires immediate treatment to avoid complications and adverse effects on the future of children and adolescents, both in terms of physical health and on the child's body image. In addition to diet, physical activity plays an important role in reducing the incidence of obesity. Physical activity walking is one form of obesity management that has been proven to reduce weight. This writing aims to perform the management of physical activity walking on weight loss in adolescents with obesity.
 Results: This intervention was given for 12 times to two teenagers in the Srengseng Sawah area, Jagakarsa, South Jakarta who had the criteria for obesity results with a BMI more than the 95th percentile. The results of the implementation for 4 weeks showed that there was a weight loss of 3.1kg for the first client and 2kg for the second client after the intervention of walking physical activity, so it can be concluded that the intervention of walking physical activity has an effect on weight loss in adolescents with obesity.
 Conclusion: Community nurses are expected to apply walking physical activity interventions as one of the interventions in overcoming obesity in adolescents.

Weight Loss History and Its Association with Self-Esteem and Eating Behaviors in Adolescents and Young Adults with Obesity

Introduction: Previous weight loss attempts in young people with obesity may have influenced their beliefs about themselves and contributed to maladaptive eating behaviors. Therefore, we aimed to investigate the association between previous weight loss with self-esteem and different eating behaviors in adolescents and young adults with obesity seeking specialty obesity care. Methods: We performed a cross-sectional study, where a total of 224 participants with obesity, aged 16–25, self-reported the amount and the frequency of previous weight loss of 5 kg or more. Self-esteem was assessed with Rosenberg’s Self-Esteem Scale and eating behavior with the Three-Factor Eating Questionnaire-Revised21. Linear regression was used to analyze associations between the amount of weight loss (no weight loss, 5–10 kg, and >10 kg) and the frequency of weight loss ≥5 kg (0, 1, and ≥2 times) with self-esteem and eating behaviors. Results: We found that both those who had lost 5–10 kg and those who had lost ≥5 kg twice or more, had statistically significantly higher cognitive restraint eating scores β = 7.03 (95% CI: 0.004–14.05) and β = 8.32 (95% CI: 1.20–15.43), respectively, compared to those who reported no previous weight loss. No other statistically significant associations were found. Conclusion: Previous weight loss in adolescents and young adults with obesity may be associated with a higher cognitive restraint eating behavior. Therefore, assessing weight loss history and eating behavior may be beneficial to better individualize obesity treatment.

Weight loss in adolescents with down syndrome compared to adolescents with other intellectual disabilities enrolled in an 18-month randomized weight management trial.

There is limited information on the efficacy of weight management interventions in adolescents with Down Syndrome (DS). To compare weight change and intervention compliance between adolescents with DS compared to adolescents with non-DS related intellectual disabilities (ID) who were enrolled in an 18-month weight management trial. Participants were adolescents (13-21 years) with mild to moderate ID and overweight or obesity. Participants were randomized in a 1:1:1 allocation to one of 3 intervention arms for an 18-month weight management trial: face-to-face/conventional diet (FTF/CD), remote delivery/conventional diet (RD/CD), or remote delivery/enhanced Stop Light Diet (RD/eSLD). Anthropometrics were assessed at baseline 6, 12, and 18 months by staff blinded to the intervention, and self-monitoring data was collected across the 18-month study. As an unpowered, post-hoc, secondary analysis, two-sample t-tests were used to compare the weight change across 6,12, and 18 mos. and compliance across 18 mos. between adolescents with and without DS randomized to each intervention arm. Adolescents with ID (n = 110) were randomized to one of three intervention arms: FTF/CD (n = 36, DS = 17, other ID = 19), RD/CD (n = 39, DS = 21, other ID = 18) or RD/eSLD (n = 35, DS = 15, other ID = 20). Body weight at 18 months was obtained from 82%, 76% and 73% of participants with DS and 84%, 83% and 75% of participants with other ID randomized to the FTF/CD, RD/CD, and RD/eSLD arms, respectively Weight change across 18 months was -0.2 ± 8.8 kg (-0.5%), -0.3 ± 5.3 kg (-0.7%), and -2.6 ± 5.0 kg (-4.0%) in adolescents with DS randomized to the FTF/CD, RD/CD and RD/eSLD arms, respectively. There were no significant differences in change in body weight or BMI across 18 months between adolescents with DS or those with other ID in any of the 3 intervention arms (all p > 0.05). Additionally, there were no significant differences in intervention compliance between adolescents with and without DS across 18 mos. (all p > 0.05). Adolescents with DS respond to a multi-component weight management intervention similar to those with others ID.

ODP576 A pilot randomized clinical trial of intranasal oxytocin to promote weight loss in children, adolescents, and adults with hypothalamic obesity

Abstract Many individuals with brain tumors affecting the hypothalamus and pituitary gain weight excessively after tumor treatment. There is currently no FDA-approved treatment for this condition, which is called hypothalamic obesity. In animals and in some preliminary studies in humans, the hypothalamic hormone oxytocin impacts metabolism, and may be deficient in individuals with hypothalamic obesity. Therefore, we performed a randomized, double-blind, placebo-controlled, cross-over trial to test the effects of 8 weeks of intranasal administration of oxytocin as compared to placebo on body weight in children, adolescents, and young adults (ages 10-<35y) with excess weight gain related to hypothalamic/pituitary brain tumors (N=13). We did not detect an effect of oxytocin on body weight or other metabolic measures. Overall oxytocin appeared well-tolerated, with most side effects being mild and not different from placebo. Our pilot study yielded several other lessons. First, affected individuals have many other medical problems. Also, individuals with hypothalamic obesity also differ from each other with respect to factors that impact body weight (e. g., appetite and eating behavior) and thus future larger studies could test different individualized dosing strategies, combination therapies, and a wider scope of outcomes to examine further the potential value of oxytocin treatment in this disorder. Keywords: Craniopharyngioma, Hypothalamic Dysfunction, Hypothalamus, Obesity, Weight Loss. Presentation: No date and time listed

Short- and long-term mortality after bariatric surgery in children and adolescents: A systematic review

In this study, we reviewed mortality rate and its causes after bariatric surgeries in children and adolescents. This was a systematic review according to the PRISMA guidelines. All human studies as cohort, observational, randomized clinical trial (RCT) and cross-sectional in children and adolescents that reported long and short-term mortality after bariatric surgery were considered for initial evaluations. in total, 8 articles were eligible for inclusion in the study. The all-cause mortality rate was 0.02% which is lower than what reported in adults. The overall results of this systematic review suggest that bariatric surgery is safe for weight loss in children and adolescents with morbid obesity. Causes of death in the literature were mostly cardiac events (infarction, failure or collapse), hypoglycaemia, overdose and suicide. • Bariatric surgery is safe and effective for weight loss in children and adolescents with morbid obesity. • The all-cause mortality rate of bariatric surgeries in adolescents is 0.02%, which is lower than what reported in adults. • Healthcare providers should be persuaded to refer children with morbid obesity for surgery.

Medical treatment of weight loss in children and adolescents with obesity

Obesity remains one of the biggest health problems both in adults and children. Lifestyle modification, including diet and exercise, continues to be the mainstay of obesity prevention and treatment. Unfortunately, lifestyle modifications are often unsuccessful. Pharmacological treatment of obesity in pediatric patients can be applied in selected cases, and not before evidence of failure of the multidisciplinary lifestyle intervention. In this narrative review, we revised the most up-to-date evidence on medical treatment of weight loss in children and adolescents with obesity, including FDA- or EMA-approved and -experimented, not approved, drugs for pediatric population. Multidisciplinary treatment of childhood obesity, regulation of appetite control, energy balance and body weight were also discussed, in order to clarify the indications and mechanism action of drugs. Despite a substantial number of medications used for the treatment of obesity in adults, a limited number of drugs are approved by the drug regulatory agencies for pediatric population. Further research is needed to evaluate the efficacy and safety of novel pharmacological approaches for treatment of pediatric obesity in order to optimize weight management for children and adolescents and limit the development obesity-related comorbidities.

Patterns of body weight change affect weight loss during a multidisciplinary intervention in adolescents with obesity

AimThe current pediatric obesity health challenge necessitates a better understanding of the factors affecting weight loss success during interventions. The aim of this observational study was to test the impact of the rate of initial weight loss and body weight variability on weight loss during a 9-month residential, multidisciplinary weight loss program in adolescents with obesity. MethodsThis retrospective study considered a whole sample of 510 adolescents with obesity (12–16 years, 435 girls). Body weight assessment was performed before (T0) and each week during the 9 months of a multidisciplinary weight loss program. Initial weight change (week 4-W4) and overall weight change at week 12 (T1) and the end of the intervention (T2) were considered. Participants were divided into three groups (tertiles), based on their percentage of weight loss between T0 and W4; and weight variability was expressed by the root mean square error (RMSE) around each participant’s regression line at each considered period (W4, T1, T2). ResultsAdolescents with lower initial weight loss at W4 (tertile 3) displayed the lesser weight loss at T1 and T2 compared with adolescents in tertile 1 and 2. The RMSE was positively associated with the percentage of weight loss of the period considered, but when the analyses were adjusted for age and initial body weight, there was no more significant association. ConclusionsThe rate of weight loss during the first few weeks is crucial for weight loss success, and weight variability is positively associated with weight loss in adolescents with obesity. Overall, results show that initial body weight is a determinant characteristic to consider during a lifestyle intervention. Further studies are thus needed to better understand the relationship between body weight change patterns and weight loss during the dynamic state that is adolescence.

Restlessness and an Increased Urge to Move (Drive for Activity) in Anorexia Nervosa May Strengthen Personal Motivation to Maintain Caloric Restriction and May Augment Body Awareness and Proprioception: A Lesson From Leptin Administration in Anorexia Nervosa.

Anorexia nervosa (AN), a disorder of voluntary food restriction leading to severe weight loss in female adolescents, remains an enigma. In particular, the appropriation of the starved thin body into the self-concept in AN is a process insufficiently researched and still poorly understood. Healthy humans undergoing starvation experience a slowing of movements and avoid voluntary exercise. By contrast, AN tends to be not infrequently associated with voluntary, sometimes excessive and/or compulsive exercise. Such deliberate exercise, not reported in starvation, seems to be facilitated by an increased urge for movement and physical restlessness, particular to AN. The increased urge to move would reflect spontaneous daily activity, the energy expended for everything that is not sleeping, eating, or voluntary exercise. Our hypothesis is that the starvation-induced increased urge to move and restlessness may promote the development of AN. Reversal of the fasting state, by either high caloric food or by leptin administration, would be expected to reduce restlessness and the increased urge to move along with improvement in other symptoms in AN. This review explores the idea that such restless activation in AN, in itself and through accelerating body weight loss, might foster the integration of the starving body into the self-concept by (1) enhancing the person’s sense of self-control and sense of achievement and (2) through invigorating proprioception and through intensifying the perception of the changing body shape. (3) Tentative evidence from studies piloting leptin administration in chronic AN patients which support this hypothesis is reviewed. The findings show that short term administration of high doses of leptin indeed mitigated depressive feelings, inner tension, intrusive thoughts of food, and the increased urge to be physically active, easing the way to recovery, yet had little influence on the patients’ personal commitment to remain at a low weight. Full recovery then requires resolution of the individuals’ personal unresolved psychological conflicts through psychotherapy and frequently needs specialized treatment approaches to address psychiatric co-morbidities. AN might be conceptualized as a hereditary form of starvation resistance, facilitated by the effects of starvation on fitness allowing for an exceptionally intense personal commitment to perpetuate food restriction.

Does metformin cause weight loss in children and adolescents without diabetes mellitus?

Does metformin cause weight loss in children and adolescents without diabetes mellitus?

Menstrual dysfunction in adolescent girls who are overweight: a literature review

This study aimed to review the modern literature on the problems of adolescent obesity and the pathogenesis of menstrual dysfunction in overweight adolescents and women of reproductive age. In recent years, a large number of works have been published on the relationship of hyperinsulinemia with ovarian hyperandrogenism. Most authors recognize that insulin resistance and hyperinsulinemia contribute to polycystic ovary syndrome formation. The formation of menstrual disorders in overweight girls is based on the violation of gonadotropin secretion, insulin resistance, and hyperinsulinemia, which over time lead to hyperandrogenism. A decreased level of somatotropic hormone and insulin-like growth factor and an increased level of leptin leads to malfunctions in the correct functioning of the hypothalamic-pituitary system. These changes disturb the ovulatory function and, consequently, adolescent reproductive health. The relationship between obesity and depression is actively discussed by foreign authors, and the obtained results often contradict each other. Most studies suggest that excessive weight gain during adolescence can lead to depression, negative mood, and low self-esteem.
 This study analyzes the results of research by domestic and foreign authors on the issues of diagnosis and treatment. Menstrual disorder therapy against the background of overweight adolescent girls is a matter of dispute among clinicians. With weight loss in adolescents, a significant improvement is found in carbohydrate and lipid metabolism, decreased levels of hepatic transaminases, and a decreased severity of obstructive sleep apnea syndrome.

MODIFICATION OF THE BEST DIET (REGULARLY LOW ENERGY BALANCED) FOR OBESITY YOUTH

Background: Obesity is a teenage health problem that needs to be addressed. One of the handling efforts in overcoming excess weight is proper eating/diet settings. Research Methods: This type of research is a quasi-experimental design with a randomized pre-post test control group design. The research subjects used in this study were female adolescents aged 18-20 years with overweight nutritional status. The variables measured were body weight before and after treatment. The data obtained were tested statistically univariate to get an overview of the distribution of research variables and bivariate test to determine the effect of the REST diet on changes in body weight. Research Result: The results showed that the average weight loss in the treatment group was 0.92 kg, and the control group was 0.67 kg. From the results of the Paired-samples T-Test, a significant value of 0.000 (p <0.05) was obtained, which means that there was a substantial difference in the mean weight before and after treatment. Conclusion: The conclusion is that there is a difference in body weight before and after the study, but there is no effect of giving the REST diet on weight loss in obese adolescents.Background: Obesity is a teenage health problem that needs to be addressed. One of the handling efforts in overcoming excess weight is proper eating/diet settings. Research Methods: This type of research is a quasi-experimental design with a randomized pre-post test control group design. The research subjects used in this study were female adolescents aged 18-20 years with overweight nutritional status. The variables measured were body weight before and after treatment. The data obtained were tested statistically univariate to get an overview of the distribution of research variables and bivariate test to determine the effect of the REST diet on changes in body weight. Research Result: The results showed that the average weight loss in the treatment group was 0.92 kg, and the control group was 0.67 kg. From the results of the Paired-samples T-Test, a significant value of 0.000 (p <0.05) was obtained, which means that there was a substantial difference in the mean weight before and after treatment. Conclusion: The conclusion is that there is a difference in body weight before and after the study, but there is no effect of giving the REST diet on weight loss in obese adolescents.

Yoga as a complementary therapy for obesity prevention in childhood and adolescent obesity

Background: Obesity is still one of the most serious health risks facing today's children and adolescents. Yoga has grown in popularity in the United States, and it appears to be a promising way to help adults with weight loss and management. However, research on yoga programmes aimed at weight loss in children or adolescents is limited. Objectives: The current study provided a systematic review of yoga-based interventions for weight loss in children and adolescents who were overweight or obese. Methods: The authors performed a systematic review of articles obtained from the databases Alt HealthWatch, CINAHL, SPORTDiscus, PubMed, and Web of Science. Inclusion criteria were studies that used yoga as a primary component, targeted overweight or obese children or adolescents, measured body weight or BMI as an outcome, used any type of study design, and were published in English-language peer-reviewed journals. Results: The inclusion criteria were met by nine studies in total. The majority of studies (n = 5) were conducted in the United States and implemented in schools (n = 5). Three of the studies examined were randomized controlled trials, and two had attrition rates approaching 50%.

The impact of parental bariatric surgery and patient age on laparoscopic sleeve gastrectomy outcomes in adolescents.

Adolescent obesity is multifactorial, but parental history is the most significant risk factor. Laparoscopic sleeve gastrectomy (LSG) is part of the multidisciplinary approach to adolescent weight loss. We aimed to evaluate the effects of parental history of bariatric surgery, as well as age at time of operation, on adolescents who underwent LSG at our institution. We performed a retrospective review of patients, aged 10 to 19years, who underwent LSG from January 2010 to December 2019. The adolescent bariatric surgical dataset maintained by our group was used to obtain patient demographics, weight, body mass index (BMI), and parental history of bariatric surgery. Among 328 patients, 76 (23.2%) had parents who had previously undergone bariatric surgery. These patients were significantly heavier by weight (p = 0.012) at the time of operation but had no difference in postoperative weight loss. When all patients were compared by age at operation (< 16years, n = 102, ≥ 16years, n = 226), there were few differences in outcomes. LSG is an effective approach to surgical weight loss in adolescents. Patient age should not be a barrier to weight loss surgery, especially among patients with a parental history of obesity. By intervening at a younger age, the metabolic sequelae of obesity may be reduced.

511 Automation of Home Food Inventory Scoring to Standardize Reporting, Enhance Clinical Utility, and Operationalize Delivery of Personalized Behavioral Targets

OBJECTIVES/GOALS: The Fulkerson Home Food Inventory (HFI) is widely used to assess the home food environment, a key target of behavioral weight loss trials. However, no standardized report is available. We created publicly available procedures to automate and standardize HFI reporting, yielding a personalized report to enhance this measures clinical utility. METHODS/STUDY POPULATION: Parents in the TEENS adolescent behavioral weight loss trial complete the HFI at 0-, 2-, 4-, 8-, and 12m and receive personalized reports at each timepoint. In REDCap, participants identify foods available in their home. HFI syntax is applied to calculate the obesogenic home food availability score. Categories of foods found are identified, with specific guidance provided to enhance their home food environment. Prior to automation, procedures were time intensive and error prone. To address this, HFI data are exported into Excel by a PowerShell (v7.2) command-line script using Python (v3.10) with the REDCap API. Results are calculated with F# (v6.0) using Microsoft Excel Interop API and inserted into a report template with F# using the Microsoft Publisher Interop API. This process is repeated at each timepoint. RESULTS/ANTICIPATED RESULTS: The new automated procedures significantly reduce time to generate reports and enhance accuracy. Procedures yield a 2-page individualized report that includes the obesogenic home food environment score and identifies categories of healthy items found (e.g., fruits, vegetables, whole grains) as well as areas of improvement (e.g., high-fat dairy products, processed meats). Specific items found in each category are identified. The report identifies food found in the home (e.g., chicken nuggets) with suggested healthier substitutions (e.g., lean chicken breast). This syntax and commands will be made publicly available for use in the scientific and clinical community. DISCUSSION/SIGNIFICANCE: These publicly available procedures optimize, automate, and standardize reporting for the HFI. Procedures improve efficiency within large-scale clinical trials and yield a personalized report to enhance the clinical utility of this measure and empower participants to make informed decisions about their health behaviors.