Weight Gain In Early Infancy Research Articles

Size at birth and growth trajectories to young adulthood

Few studies in developing countries follow growth trajectories from birth to adulthood. Such studies are important because size at birth and postnatal growth affect risk of chronic disease in adulthood. This study examines the inter-relationships of maternal factors during pregnancy, infant birth weight and length, early postnatal growth, and young adult height, weight, BMI, and skinfold thicknesses, with particular attention to patterns of growth associated with increased chronic disease risk. Women were recruited in pregnancy, and offspring were followed from birth to age 21 in the community-based Cebu (Philippines) Longitudinal Health and Nutrition Survey. Birth weight and length are independently, positively associated with height, BMI and sum of skinfolds in young adult males and females, and inversely associated with the subscapular to triceps ratio in males only. The effects of size at birth on adult size were modified by birth order, and remained significant after adjusting for maternal nutritional status, socioeconomic status at birth and throughout the growth period, and maturation. Early postnatal growth was strongly influenced by BMI at birth, with rapid early infant weight gain associated with thinness. The growth pattern of the at-risk group most often associated with increased risk of chronic disease (small at birth, relatively heavy as an adult), was characterized by more rapid growth in the first 4 postnatal months. The high level of inter-relatedness of maternal nutrition in pregnancy, prenatal growth, and postnatal growth emphasizes the need to consider the full growth trajectory in studies of developmental origins of adult disease.

Does breastfeeding method influence infant weight gain?

Objective:To compare the effect of traditional and “baby-led” breastfeeding advice on early infant weight gain and exclusive breastfeeding rates.Design:Longitudinal cohort study: part prospective, part retrospective.Setting:One UK general practice.Participants:63 exclusively breastfed...

Absence of the Wild-type Allele (192 Base Pairs) of a Polymorphism in the Promoter Region of the IGF-I Gene but Not a Polymorphism in the Insulin Gene Variable Number of Tandem Repeat Locus Is Associated With Accelerated Weight Gain in Infancy

Our goal was to investigate whether a polymorphism in the insulin-like growth factor I promoter gene (IGF-I, wild-type, 192 base pairs) and in the insulin gene (INS) variable number of tandem repeat locus influence birth weight and weight gain in infancy. We obtained genomic DNA from 768 children. Exclusion criteria were multiple births, gestational diabetes, maternal diabetes, gestational age <37 weeks, >42 weeks, or unclear, and any condition potentially influencing weight gain. SD scores were calculated and adjusted for gestational age and gender. A gain in SD scores for weight between birth and 1 year >0.67 SD scores was defined as accelerated weight gain. Genotyping was performed by fragment length analysis (IGF-I) and by fragment length analysis after using a restriction enzyme-based assay (INS variable number tandem repeat). Accelerated weight gain was present in 205 of 768 children. IGF-I and INS variable number tandem repeat genotype were not associated with birth weight. The IGF-I 192-base pair allele was less frequent in children with accelerated weight gain and was shown to reduce the risk for accelerated weight gain in a logistic regression model. The IGF-I 192-base pair allele may reduce the risk for rapid weight gain in early infancy.

Does Maternal Control During Feeding Moderate Early Infant Weight Gain?

Our objective with this study was to examine whether observed maternal control during feeding at 6 months of age moderates the development of early infant weight gain during the first year of life. Sixty-nine women were observed feeding their 6-month-old infants during a standard meal. Mealtimes were coded for maternal use of controlling feeding behavior. All infants were weighed at birth and at 6 and 12 months of age, and weight gain was calculated from birth to 6 months and from 6 to 12 months. Weight scores and weight gain scores were standardized for prematurity, age, and gender. Infant weight gain between 6 and 12 months of age was predicted by an interaction between early infant weight gain (birth to 6 months) and observed maternal control during feeding at 6 months. When maternal control was moderate or low, there was a significant interaction with weight gain from birth to 6 months in the prediction of later infant weight gain from 6 to 12 months, such that infants who showed slow early weight gain accelerated in their subsequent weight gain, and those with greater early weight gain decelerated. Conversely, when maternal control was high, infant weight gain followed the opposite pattern. Maternal control of solid feeding can moderate infant weight gain.

The Influence of Temperament on Weight Gain in Early Infancy

Difficult temperament has been associated with fast weight gain and slow weight gain, although the latter mostly in referred subjects studies in late infancy. The current study set out to investigate early weight gain in relation to all domains of temperament in a community-screened sample. Weight gain from birth to 8 weeks was assessed in 75 infants recruited from local health care clinics who had demonstrated slow, average, or fast weight gain. Mothers completed a temperament questionnaire and a 2-day diary recording infant behaviors (sleeping, feeding, fussing, and crying). Weight gain from birth to 8 weeks was significantly related to infant temperament. The temperament dimension fear (acceptance or rejection of new objects or persons) was related to slow weight gain and the temperament dimension distress to limitations (negative emotionality and the infant's reaction to frustrating situations) was related to fast weight gain. The regression model explained 59% of the variance, with the temperament dimensions explaining 11%. Diary data showed that infants who scored high on fear tended to cry a lot, while infants with high scores on distress to limitations tended to sleep less and cry and fuss more. The results emphasize that different temperament domains influence slow and fast weight gain. In addition, the data suggest that infant temperament plays a part in physical development in early infancy.

Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function.

Recent evidence suggests that impaired lung development is linked with diminished lung function and an increased risk of chronic obstructive airway disease in adulthood. To examine environmental influences on early lung development, we measured lung function in 131 normal-term infants aged 5-14 weeks. Adjusting for age at measurement, FEV at 0.4 seconds fell by 4.4% for each standard deviation decrease in birth weight (p = 0.047); when adjusted for FVC, FEV at 0.4 seconds was not related to birth weight but fell by 3.2% per standard deviation increase in infant weight gain (p = 0.001). Age- and sex-adjusted total respiratory system compliance fell by 7.0% per standard deviation decrease in birth weight (p < 0.001) but was not related to infant weight gain. In univariate analyses, age-adjusted forced expiratory flow at functional residual capacity was not related to birth weight, but decreased by 11.0% per standard deviation increase in infant weight gain (p = 0.007). The respiratory rate rose by 5.1% per standard deviation increase in infant weight gain (p = 0.001). Lung function measurements were not related to infant feeding. The observations suggest that lower rates of fetal growth and higher rates of early infancy weight gain are associated with impaired lung development.

Ethnicity Modifies Seasonal Variations in Birth Weight and Weight Gain of Infants

Early growth is considered critical for the development of obesity and adulthood cardiovascular diseases. Because season and environmental temperature at birth have also been associated with obesity, it is important to examine whether birth weight and postnatal weight gain vary by season. Data from the National Collaborative Perinatal Project were used to assess the influence of season on birth weight and weight gain during the first 4 mo of life. The sample included 11,091 whites, 11,477 blacks, 1536 Puerto Ricans and 221 subjects of other ethnic groups born at full-term gestation. Black infants born in the fall had a significantly lower birth weight (3.12 +/- 0.42 kg) than those born in the winter (3.16 +/- 0.43 kg, P = 0.002). This difference was not found in the other ethnic groups. Additionally, weight gain (g/mo) for black and Puerto Rican infants during the first 4 mo of life was significantly lower for those born during the fall (black: 816 +/- 186; Puerto Rican: 820 +/- 181) compared to those born in the spring (black: 844 +/- 194, P < 0.001) and summer (Puerto Rican: 861 +/- 185, P < 0.04). Birth weight and early infancy weight gain varied by season and were modified by ethnicity. The potential importance of seasonal variations in pre- and postnatal growth was evaluated in this study.

Role of Serum Leptin in the Regulation of Weight Gain in Early Infancy

We investigated the changes in the serum leptin concentration from birth to 30 days of age in order to determine the effects of leptin in early infancy. Twenty-seven Japanese term infants (12 boys and 15 girls) were examined. The serum leptin concentration at 3–6 days of age was significantly lower than that in cord blood (p < 0.0001) and was significantly higher at 30 days than at 3–6 days (p < 0.0001). The serum leptin concentration did not differ with gender or nutrition. The body weight gain and the magnitude of leptin rise that occurred between 3–6 and 30 days of age showed a significant positive correlation (r = 0.79; p < 0.0001). These changes in leptin levels suggest that leptin plays an important role in the regulation of weight gain in early infancy.

Indicators for monitoring the growth of peruvian infants: weight and length gain vs attained weight and length.

To determine appropriate indicators and age intervals for growth monitoring in this population, the relationship between monthly weight and length indicators and nutritional status at 12 months was evaluated among 102 low-income Peruvian infants. Cutoffs for defining adequate vs slow growth were obtained from published reference data, and sensitivities and specificities of each indicator were calculated. Low weight gain in early infancy, especially from 1 to 2 months, is useful for predicting low weight at 1 year (sensitivity = 81%, specificity = 65%, 25th percentile cutoff). Use of actual weight at 2 months, however, produces comparable results (sensitivity = 86%, specificity = 57%, 50th percentile cutoff). Monthly length gains were weak predictors of low length for age. Neither weight nor length gains accurately predicted the opposite form of undernutrition. Nonhuman milk consumption before 4 months and poor appetite from 3 to 12 months were related to low early weight gain and subsequent undernutrition. Growth monitoring programs in this population should enroll infants at birth, monitor actual weight, promote exclusive breast-feeding and delayed introduction of nonhuman milk, and provide specific feeding advice to mothers of infants with frequently depressed appetite.

INTESTINAL ENTEROKINASE (EK) DEFICIENCY IN 2 SIBLINGS

EK is a key enzyme for protein digestion since it catalyses the conversion of trypsinogen to trypsin, which in turn activates other pancreatic proteolytlc zymogens. 2 cases of EK deficiency are described. A male infant developed diarrhea, vomiting, anemia, and generalized edema due to hypoproteinemia within a few weeks of birth. Weight gain was poor. Formula change to Nutramigen resulted in temporary improvement but at age 4 months he was very malnourished. Cystic fibrosis was excluded. Duodenal juice showed no proteolytic enzyme activity but amylase and lipase were present. Following the in vitro addition of porcine EK to the juice, normal trypsin and chymotrypsln activity was observed. Duodenal mucosa had no EK activity. The patient was treated with pancreatic extract and began to thrive. At 3 1/2 years he is growing normally and no longer needs pancreatic therapy. His older sister also had diarrhea, anemia, hypoproteinemia and poor weight gain in early infancy. She was fed Nutramigen and recovered. Her duodenal juice and mucosa showed the same abnormality as that of her brother. EK deficiency, which may result in variable clinical expression, is treatable and should be looked for in infants with unexplained vomiting, diarrhea, anemia and hypoproteinemia.