Changes in growth and hair zinc concentrations following a 6 month nutrition rehabilitation study were assessed for 41 (18F and 23M) individuals with severe developmental disabilities. Subjects were classified according to weight-for-height (WH) Z-scores: Group 1 (n=26) <−1.650, Group 2 (n=11) −1.645 to +1.030, Group 3 (n=4) >+1.036. The goal of the nutrition program was to increase, maintain, or decrease the rate of weight gain in each group, respectively. Following the program, mean height-for-age (HA) Z-scores increased in group 1 and group 2. Weight-for-age (WA) Z-scores increased in Group 1 and Group 3. At one year, WA Z-scores increased in Group 1 only. Scalp hair zinc was analyzed by instrumental neutron analysis at baseline and 1 year. All groups had mean hair zinc concentrations above the value (1.07 umols/g) indicative of sub-optimal zinc status. Following the nutrition intervention program: (a) mean dietary zinc intakes (adjusted for 20% absorption) exceeded 66.7% of the Canadian Recommended Intake for greater than 90.9% of subjects; (b) there was no correlation between HA Z-scores and hair zinc values; and (c) hair zinc values were correlated with WA and WH Z-scores in group 1 and WH Z-scores in Group 3. These findings suggest that a stronger association between zinc status and weight in contrast to height.
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