The interest of the average surgeon or radiologist in giant-cell tumors never lags because of too great familiarity. This report is based on a review of 29 cases, principally from the service of Dr. E. P. Pendergrass of the University of Pennsylvania Hospital, Drs. Geo. E. Pfahler, Karl Kornblum, and Arthur Finkelstein, of the Graduate Hospital, University of Pennsylvania, and from the author's services at the Skin and Cancer Hospital, Philadelphia, and the Newcomb Hospital, Vineland, N. J. The collection of giant-cell tumors in the X-Ray Museum of the Temple University Hospital assembled by Dr. W. E. Chamberlain was inspected with much profit, but is not included in this series for discussion. Most of the cases in the group were treated more than five years ago, one as long as thirteen years ago. There is little value in statistics based on so small a number of cases, but the experience encountered in many of this series offers some grounds for discussion. Fourteen patients treated by irradiation alone showed good long-term results, on the whole. Some suffered intercurrent fractures, but none lost time from other complications. Leucutia, Witwer, and Belanger (5) reported similar satisfactory late results with radiation therapy of giant-cell tumors. Two cases underwent malignant change, one six years and the other nine years after treatment. In 14 cases treated by surgery and irradiation good results were also obtained, but with a greater incidence of intercurrent fractures, repeated operations, and infections, and with longer periods of morbidity. One impression gained from this review is the value of fixation or splinting, whether irradiation therapy is used alone or in combination with surgery. It sometimes seemed that immobilization was almost as important as the radiotherapeutic or operative management of the case. Surprisingly good results were obtained when little radiation was employed, in some instances purposely and in other cases because of poor cooperation on the part of the patient. In one patient, who had known of the presence of a tumor in the upper end of the right humerus and had refused treatment for twenty-eight years, an organized stable-appearing giant-cell tumor was revealed by x-ray examination. If these tumors can heal spontaneously, it may be that the simple measure of preventing fractures by proper splinting and removal of weight-bearing stresses for a sufficiently long period is a more important factor than is realized in the ultimate cure, the splinting to be done to spare the part from weight-bearing, not from other active or passive use. It appeared that healing occurred more rapidly while the part was at rest than during the other phases of the therapeutic course. Healing took place faster in children than in adults and apparently with smaller amounts of radiation.