You have accessJournal of UrologyStone Disease: SWL, Ureteroscopic or Percutaneous Stone Removal I1 Apr 20101445 C-REACTIVE PROTIEN: A NOVEL MARKER FOR EXPULSION RATE OF LOWER URETERIC CALCULI? Altaf Khan and Manjunath Shetty Altaf KhanAltaf Khan More articles by this author and Manjunath ShettyManjunath Shetty More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1159AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Plasma C - reactive protien (CRP) is an acute phase protien which becomes elevated in inflammatory disorders. It is also increased in ureteric obstruction with pyelonephritis. Presence of edema and infection decreases the chances of expulsion of ureteric calculi. We used CRP as a marker to detect the expulsion rate of lower ureteric calculi following medical expulsive treatment. METHODS From January 2009 to June 2009, 100 consecutive patients with lower ureteric calculi, size ranging from 5-7mm with mild symptoms were included in the study. All patients were investigated in form of X-ray KUB, USG KUB and CRP. Patients were subjected for medical treatment with alpha blockers (tamsulosin 0.4mg in patients >40yrs and alfuzosin 10mg in <40 yrs age group), diuretics and analgesics whenever required. Of 100 patients 46 patients had CRP <20 mg/L, 26 patients between 20-40 and 28 patients had CRP >40mg/L. Average stone size was comparable for all the groups. RESULTS Patients were followed up after 3 weeks of medical treatment. Patients were assessed for symptom relief, investigated with X-ray KUB and USG KUB. Of the 46 patients with CRP <20 mg/L, 40(86.9%) had passed the stone. Of 26 patients with CRP between 20-40, 12(46.15%) had passed the stone. But of 28 patients with CRP >40 only 3(10.71%) had passed the stone. Patients with non expulsion of stone were subjected for Ureterorenoscopy and intracorporeal lithotripsy. CONCLUSIONS CRP is a novel sensitive marker in deciding the stone expulsion rate in patients with small sized (5-7mm) lower ureteric calculi. Patients with CRP >40mg/L should directly be subjected for intervention instead of medical therapy. Mangalore, India© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e557 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Altaf Khan More articles by this author Manjunath Shetty More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...