Week Of Moderate Physical Activity Research Articles

A qualitative exploration of the health needs and goals of urban women to inform the tailoring and adaptation of Strong Hearts Healthy Communities: a community-based cardiovascular disease prevention intervention

BackgroundIn the United States, cardiovascular diseases (CVD) are the leading cause of death and disability in women. CVD-modifiable risk factors, including poor diet quality and inadequate physical activity, can be addressed through evidence-based interventions (EBIs). Strong Hearts Healthy Communities (SHHC) is an EBI that has demonstrated effectiveness in reducing CVD risk and improving health outcomes among rural white women. The aims of this study were to understand the general health, diet, and physical activity-related needs and goals of women living in an urban community, to inform the tailoring and adaptation of the SHHC EBI to an urban setting and more diverse population.MethodsFocus groups (FGs) were conducted with African American/Black and Hispanic/Latinx women in the Dallas metropolitan area who had a BMI ≥ 25 kg/m2 and engaged in ≤ 150 min per week of moderate physical activity. The data were coded using a team-based, deductive, and thematic analysis approach, that included multiple coders and in-depth discussions.ResultsFour FGs with a total of 18 participants (79% Black and 21% Latinx) were conducted, and three themes were developed: (1) participants had adequate knowledge and positive attitudes towards healthy living but faced many barriers to practicing healthy behaviors; (2) culturally-based beliefs and community practices exerted a strong influence on behaviors related to food and stress, revealing barriers to healthy eating and generational differences in stress and stress management; (3) participants desired a more individualized approach to nutrition and physical activity interventions that included familiar and enjoyable activities and social support centered around shared health goals.ConclusionsThe SHHC intervention and similar health programs for Black/African American and Hispanic/Latinx women in urban settings should emphasize individualized nutrition and practical skills for healthy eating with accessible, familiar, and enjoyable exercises. Additionally, stress management strategies should be culturally and generationally sensitive and social support, whether through family, friends, or other program participants, should be based on shared health goals.

Prior Lifestyle and Survival Outcomes After Intensive Care Unit Admission.

Although lifestyle is an important and modifiable risk factor for health-related outcomes, no study has focused on the impact of prior lifestyle habits on mortality among critically ill patients after intensive care unit (ICU) admission. Therefore, we aimed to investigate whether prior lifestyle factors affected short- and long-term survival after ICU admission. In this population-based cohort study using a nationwide registration database in South Korea, we included all patients who were admitted to the ICU between January 1, 2010 and December 31, 2018 and who had undergone standardized health examinations in the year prior to ICU admission. Three lifestyle factors (smoking status, alcohol consumption, and physical activity) were evaluated prior to ICU admission. In total, 585,383 patients admitted to the ICU between 2010 and 2018 were included in the analysis. Of them, 59,075 (10.1%) and 113,476 (19.4%) patients died within 30 days and 1 year after ICU admission, respectively. Current smoking, mild alcohol consumption, and heavy alcohol consumption were not associated with 30-day mortality after ICU admission. One to 3 days per week of intensive physical activity, 4-5 days and 6-7 days per week of moderate physical activity, and 1-3 days, 4-5 days, and 6-7 days per week of mild physical activity were associated with lower odds of 30-day mortality after ICU admission. Similar results were observed for the analyses of 1-year all-cause mortality after ICU admission. Prior lifestyle factors, such as physical activity, were associated with the improvement of both short- and long-term survival outcomes in South Korea. This association was more evident for mild physical activities, such as walking, than for intensive physical activities.

Impact of Fitness Influencers on the Level of Physical Activity Performed by Instagram Users in the United States of America: Analytical Cross-Sectional Study.

Physical activity positively influences the general population's health. Social media networks may promote changes in physical activity habits. This study aimed to analyze the relation between being encouraged to perform physical activity by fitness influencers on Instagram and the level of physical activity performed. An analytical cross-sectional study was performed in 890 United States residents with an Instagram account. The sample was made up of 79.2% females and of 75.4% millennials (born between 1981-1996). Physical activity was measured with the International Physical Activity Questionnaire. Sociodemographic characteristics were registered. The percentage of females (p = 0.001), millennials (p < 0.001), students (p < 0.001), participants with normal BMI (p = 0.001), and participants performing more than 150 min per week of moderate physical activity (p = 0.014) was significantly higher in the group that felt encouraged to perform physical activity by the information posted by fitness influencers. This group spent a median of 2 h per week on Instagram checking for nutrition or exercise (p < 0.001). United States residents who felt encouraged to perform physical activity by fitness influencers on Instagram achieved more the World Health Organization recommendations for substantial health benefit for moderate physical activity. They were predominantly females and millennials with normal weight and spent more time on Instagram checking for nutrition or exercise.

Recommendations of the Schizophrenia Expert Center network for adequate physical activity in real-world schizophrenia (FACE-SZ).

The World Health Organization (WHO) recommends adults complete 150-300min per week of moderate physical activity or 75-150min of vigorous physical activity or an equivalent combination of both, to optimize health. To explore the factors associated with adequate MVPA in stabilized outpatients with schizophrenia. 425 stabilized outpatients were recruited in the national FACE-SZ cohort between 2015 and 2018 were evaluated with the International Physical Activity Questionnaire and a 1-day long standardized battery. We explored in multivariate analyses the clinical and pharmacological factors associated with MVPA (model 1) and the biological factors and patient-reported outcomes (model 2). Overall, only 86 (20.2%) of the 425 participants achieved the recommended MVPA threshold. In model 1, the adequate MVPA group was associated with younger age, mood stabilizers prescription and adherence to treatment, independent of sex, positive and depressive symptoms, first-generation antipsychotics prescription, anxiolytic medication, and akathisia. In model 2, adequate MVPA was associated with better glycemic and lipidic profile and better physical and psychological well-being, self-esteem, sentimental life, and resilience independently of age, sex, and current psychotic severity. The expert centers recommend the importance of promoting promote effective MVPA programs for stabilized patients with schizophrenia. Interventions studies suggest that MVPA may be a useful strategy to maximize physical and psychological well-being and self-esteem and potentially to prevent or manage metabolic disturbances.

Effect of Brisk Walking and Moderate Resistive Exercises on Physical Fitness Level in Middle-aged Women: A Randomised Clinical Tria

Introduction: Insufficient physical activity is considered as one of the leading risk factors for global mortality and morbidity. American College of Sports Medicine recommended an engagement of minimum 150 minutes per week of moderate physical activity. Physical fitness gradually declines with aging. Low muscle strength and decline in the ability to produce force quickly (power) are associated with low walking speed and, further, with mobility limitations. In India, women are more physically inactive than men. Women shows more rapid decline in physical activity than men in middle age. This sex difference may be due to the hormonal changes and barriers such as lack of time, lack of motivation, lack of energy, self awareness and health problems. Aim: To evaluate the effect of brisk walking and moderate resistive exercises on body weight, body fat percentage (Skinfold Caliper), six minute walk distance covered and Physical Fitness Index (PFI) in middle-aged women. Materials and Methods: A randomised clinical study was conducted in Outpatient Department at Dr. D.Y. Patil college of Physiotherapy, India, from November 2021 to January 2022. Total 40 subjects, between age group of 40-60 years with low physical activity, assessed by International Physical Activity Questionnaire, were included in the study. Subjects were divided into two groups with simple random sampling using lottery method. Group A (experimental group; n=20) brisk walking with moderate resistive exercises were given. Group B (conventional group; n=20) includes only brisk walking. The protocol was given for four days a week for four weeks. The outcome measures taken were body weight, body fat percentage, physical fitness index and six minute walk distance. The statistical analysis was done using Medcalc software 18.2.1. Results: The mean age was 45.55±5.73 for group A and 43.30±4.62 for group B. The mean difference of Body weight (BW), Body Fat percentage (BF%), 6 minute walk distance (6MWD) and Physical Fitness Index (PFI) was 1.56, 1.98, -18.82, and -182.34 respectively for group A and 0.23, 1.22, -8.23, -126.16 for group B. On intergroup comparison, the mean difference of BW, BF%, 6MWD and PFI was 1.33, 0.76, -10.59 and -56.18. This shows significant difference between the groups. Conclusion: Brisk walking and moderate resistive exercise can be used as effective treatment in weight management to improve physical fitness level in middle-aged women.

The Influence of Occupational Categories on Overall and Domain-Specific Physical Activity and the Association with Chronic Diseases. An Analysis Using the Austrian Health Interview Survey.

Background: The performance of physical activity (PA) in different domains varies between different occupational groups and they contribute differently to the prevention and management of chronic diseases. This study aimed to give a fuller picture of the potential influence occupational categories have on the different domains of PA among the Austrian population of working age. Methods: A total of 8251 gainfully employed persons in 9 major and 39 sub-major occupational groups from the Austrian Health Interview Survey 2014 were analyzed. PA was measured with the Physical Activity Questionnaire of the European Health Interview Survey (EHIS-PAQ) and the prevalence of 17 chronic diseases was obtained. Results: A total of 48.2% were mostly active when working, 18.4% reported transport-related PA in the upper quintile, 50.4% performed at least 150 min per week of moderate PA or cycling, 32.7% performed muscle-strengthening PA at least twice a week, and 76.3% were either mostly physically active when working or complied with the aerobic PA guidelines. As a general rule, people in physically active occupational groups tended to perform less PA in their leisure time and vice versa. Occupational groups with especially low amount of PA were Information Technology workers, directors, and secretarial staff. People with a chronic disease tended to perform less PA, but there was an interaction between occupation and chronic disease on PA. Conclusions: Domain-specific programs to promote PA should be developed for various occupational categories.

Home Based Physical Exercise for Prevention and Management of COVID-19Pandemic and for its Associated Consequences

The COVID-19 pandemic has forced many of us round the world to remain reception and self-isolate for a long period of time. These leads to psychological outcomes such as depression, post-traumatic stress symptoms, panic, confusion, anger, fear, and substance misuse and develops Sedentary Death Syndrome and reduce individuals’ functional ability. But at this time if an individual follows a physically active lifestyle or participate regularly in home based physical activity, it has been found to be an effective way of improving fitness and overall health of individual. The effect of regular home based exercise training has a significant positive effect on overall health of individuals. The World Health Organization (WHO) has recommended clear guidelines on the minimal amount of physical activity necessary to maintain health and fitness. Based on age categories, 60 min per day of moderate-to-vigorous physical activity for 6-17-yr-olds, and 75 min per week of vigorous or 150 min per week of moderate physical activity for adults and elderly, including 3 and 2 days per week, respectively, with muscle and bone strengthening. Generally, mental and physical well-being are negatively affected by sedentary habits of physical activity and positively affected by active lifestyle (regular physical activity).

Factors Associated with Objectively Measured Physical Activity in Patients with Seropositive Rheumatoid Arthritis.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is associated with low levels of physical activity (PA). However, the factors related to low physical activity levels have rarely been studied. Methods: In this cross-sectional study, 70 seropositive RA patients were included. Physical activity was objectively assessed with an ActiGraph GT3X+ accelerometer. In addition, body mass index, smoking status, work ability, and clinical parameters (functional disabilities, disease activity, disease duration, pain, and inflammation parameters) were measured. Results: RA patients performed a mean of 215.2 (SD: 136.6) min a week of moderate physical activity and 9.1 (SD: 26.3) min of vigorous physical activity. The total amount of moderate and vigorous physical activity (MVPA) was associated with BMI, and functional disabilities. In addition, non-smokers and patients with better work ability did more MVPA. No association could be seen with disease activity, disease duration, pain, and inflammatory markers. After mutual adjusting of all the variables, only BMI showed a significant relationship with MVPA. Conclusions: RA patients perform de facto no physical activity with vigorous intensity. Factors related to low physical activity are BMI, functional disabilities, workability and smoking status, whereas due to the study design no causal and temporal link could be made.

Physical Activity Level and Perception of Exercise in Cystic Fibrosis

More patients with cystic fibrosis (CF) are living longer, and lifestyle-related behavior is becoming increasingly important for improving morbidity and mortality. Declining levels of exercise leads to low cardiorespiratory fitness, which is a strong, independent predictor of mortality in patients with CF. As a result, exercise training has become a commonly accepted form of treatment for patients with CF. The purpose of this study was to determine physical activity levels and perception of exercise in adult patients with CF. Adult patients from an in-patient CF unit were recruited to participate. A structured interview and self-report questionnaires were used to collect information on levels of physical activity and exercise perception including preferences, readiness, and barriers. Forty-six adult patients with CF consented to participate in the interview and completed self-report questionnaires. Subjects self-reported that the majority (84%) of their time was spent performing physical activity at a moderate level, with mean ± SD of 11.8 ± 12.2 h per week of moderate physical activity. Vigorous physical activity was described as hard and very hard physical activity, with a mean ± SD of 1.8 ± 4.6 h (13%) and 0.4 ± 1.6 h (3%), respectively. Most of the adult subjects with CF preferred walking, and 65% of them felt that exercise was very important. Lack of energy, lack of good health, lack of self-discipline, and lack of time were noted as the most frequent barriers to exercise. In this study, adult subjects with CF self-reported performing an adequate amount of moderate physical activity, although only a small proportion of time was spent at a vigorous level of physical activity. Clinicians providing rehabilitation have an opportunity to improve adherence to prescribed exercise by understanding the impact that physiological and psychological factors have on patients with CF. Further, motivating patients with CF to engage in more vigorous physical activity may provide a stimulus that improves clinical outcomes and potentially survival.

P05 A Comprehensive Plan for Safe and Sustainable Bicycling in Baltimore, Maryland

BackgroundPurpose: This paper summarizes the results of a policy analysis discussing the benefits for Baltimore, Maryland (USA), in adopting and implementing a comprehensive bike policy. A comprehensive bike policy includes well-labeled protected bikes lanes and the adoption of a citywide bikeshare program, among other measures. Baltimore is poised to benefit from a comprehensive bike policy because of its age and socioeconomic makeup, medium land area, and population density. Experiences in other progressive biking cities throughout North America have demonstrated how the full integration of bicycles in transit and transportation strategies positively impact the health of the local population, the economy, and the environment. MethodsMethod: The research consisted of a systematic comparison of the health, environmental, and economic impacts associated with comprehensive biking policies in a sample of US cities with comparable demographics as Baltimore. ResultsRelevance: Despite a few attempts, Baltimore has yet to successfully create a comprehensive biking framework to integrate biking into the culture of the city and its transportation policy. Three sectors in particular would benefit from a new initiative. Health - Currently, Baltimore ranks 43rd out of 50 large US cities in meeting the recommended amount of daily activity, with only 46.1% of the population achieving the suggested 150min a week of moderate physical activity. In addition, currently 66.4% of the Baltimore population is obese or overweight, and this number is on the rise. Economic - Baltimore׳s median annual income is $39,561, 6th lowest in the USA, with 34% of the population living below the poverty line. Although individuals with higher income tend to be overrepresented in bikeshare use, individuals with income of $25,000 or less are more likely to bike in general. Environmental - There is a direct threat to Baltimore and Maryland if action isn׳t taken to reduce emissions and prevent climate change. The rise in sea level, increased extreme weather events, and changes in the complex ecosystem all pose serious threats to a coastal city with a highly vulnerable population. ConclusionsThe analysis establishes that if Baltimore were to implement protected bike lanes in tandem with a bikeshare program, it would see an increase in bike use, population health, and city morale, as well as a decrease in traffic congestion and carbon emissions. Depending on the extent of adoption, Baltimore will see more or less important improvements in the aforementioned essential areas of responsibility. A summary plan for implantation is suggested in conclusion.

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

These recommendations are based on the following: (1) a formal review and analysis of the recently published world literature on the topic [Medline search up to June 2011]; (2) the American College of Physicians’ Manual for Assessing Health Practices and Designing Practice Guidelines; (3) guideline policies of the three societies approving this document; and (4) the experience of the authors and independent reviewers with regards to NAFLD. Intended for use by physicians and allied health professionals, these recommendations suggest preferred approaches to the diagnostic, therapeutic and preventive aspects of care. They are intended to be flexible and adjustable for individual patients. Specific recommendations are evidence-based wherever possible, and when such evidence is not available or inconsistent, recommendations are made based on the consensus opinion of the authors. To best characterize the evidence cited in support of the recommendations, the AASLD Practice Guidelines Committee has adopted the classification used by the Grading of Recommendation Assessment, Development, and Evaluation (GRADE) workgroup with minor modifications (Table 1). The strength of recommendations in the GRADE system is classified as strong (1) or weak (2). The quality of evidence supporting strong or weak recommendations is designated by one of three levels: high (A), moderate (B) or low-quality (C). This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.

The association of physical activity, sedentary behaviors, and body mass index classification in a cross-sectional analysis: are the effects homogenous?

BackgroundWhile much is known about the benefits of physical activity (PA) and the consequence of sedentary behaviors relative to body mass index (BMI), little is known about the homogeneity of these effects across individuals. The goal of this study was to determine if PA and sedentary behaviors have the same effect on individuals of all BMI classifications.MethodsData from a community health assessment were analyzed and a sample was selected to include respondents who self-reported a chronic disease associated with obesity (n = 2,840). Descriptive statistics were used to describe the association between selected independent variables and BMI. Simultaneous quantile regression was used to identify the degree of homogeneity in the effect of demographic independent variables, minutes per week of moderate PA, and hours per day spent watching television on BMI classification. In studies using simultaneous quantile regression, the word "effect" is used to describe association, not causation.ResultsMinutes per week of moderate PA had a significant effect on lower BMI, but only when respondents were at least classified as obese-class I (β = -0.001, p = 0.006). The change in effect of moderate PA in lower BMI increased significantly when respondents were classified as obese-class II versus obese-class I (F = 4.54, p = 0.033). Hours per day spent watching television had a significant effect on higher BMI, but only when the respondent was at least classified as overweight (β = 0.87, p < 0.001). The change in effect of watching television on higher BMI increased significantly when respondents were classified as obese-class I versus overweight (F = 5.57, p = 0.018).ConclusionPA and watching television were more related to BMI for obese individuals than those who were just overweight. Customized interventions for specific BMI classifications should be developed to maximize public health benefits.

Physical Self-Perceptions, Body Size, and Exercise Among Breast Cancer Survivors

The diagnosis of breast cancer and subsequent treatment often results in physical and psychological challenges. Because cancer treatment can have a negative effect on physical self-perceptions (PSP) and quality of life (QOL), it is important to investigate this relationship and develop strategies to help survivors address these factors. PURPOSE: To explore the relationship of exercise behavior, fitness, body size and PSP among women recently diagnosed with Stage II and III breast cancer receiving neoadjuvant chemotherapy and to examine the association between PSP and QOL. METHODS: Women (n=40) participated in a pilot study of a weight gain prevention intervention for breast cancer survivors combining exercise and dietary approaches. We analyzed baseline data using correlation analysis to examine associations among PSP, exercise, fitness measures, body size, and QOL measures. RESULTS: There were significant negative correlations between Body Mass Index (BMI) and PSP for attractive body, physical function, self-worth and (rs= -.52, -.56, -.58); however, fitness measures were not associated with PSP scores. Women who reported participating in ≥150 minutes of moderate physical activity per week had significantly higher PSP physical function scores (t(13)=2.43, p=.01). We found significant positive associations between PSP for physical function and QOL including vitality (r=.48), role emotional (r=.43), general health (r =.42) social (r=.39) and physical (r=.37) functioning as measured by the MOS SF-36. CONCLUSION: Women participating ≥150 per week of moderate physical activity had significantly higher perceptions physical function, and PSP of physical function was associated with QOL among women recently diagnosed with Stage II and III breast cancer. Examining how PSP might affect survivors' receptivity to a weight gain prevention intervention during treatment, and the influence of such an intervention on subsequent self-perceptions and QOL could inform future weight management intervention development for survivors.

Physical Activity and Risk of Recurrence and Mortality in Breast Cancer Survivors: Findings from the LACE Study

Identifying modifiable factors that reduce the risk of recurrence and improve survival in breast cancer survivors is a pressing concern. The purpose of this study was to examine the association of physical activity following diagnosis and treatment with the risk of breast cancer recurrence and mortality and all-cause mortality in women with early-stage breast cancer. The sample consisted of 1,970 women from the Life After Cancer Epidemiology study, a prospective investigation of behavioral risk factors and health outcomes. Self-reported frequency and duration of work-related, household and caregiving, recreational, and transportation-related activities during the six months prior to enrollment were assessed. Outcomes were ascertained from electronic or paper medical charts. Hazard ratios and 95% confidence intervals were estimated from delayed entry Cox proportional hazards models. Although age-adjusted results suggested that higher levels of physical activity were associated with reduced risk of recurrence and breast cancer mortality (P for trend = 0.05 and 0.07, respectively for highest versus lowest level of hours per week of moderate physical activity), these associations were attenuated after adjustment for prognostic factors and other confounding variables (P for trend = 0.36 and 0.26). In contrast, a statistically significant protective association between physical activity and all-cause mortality remained in multivariable analyses (hazard ratio, 0.66; 95% confidence interval, 0.42-1.03; P for trend = 0.04). These findings do not support a protective effect of physical activity on breast cancer recurrence or mortality but do suggest that regular physical activity is beneficial for breast cancer survivors in terms of total mortality.

Weight History, Smoking, Physical Activity and Breast Cancer Risk among French-Canadian Women Non-Carriers of More FrequentBRCA1/2Mutations

Several lifestyle factors play a significant role in determining an individual's risk of breast cancer. Many of them could be modified to protect against the malignancy. A nested case-control study was conducted to examine the association between selected lifestyle factors and non-BRCA-related breast cancer risk among French-Canadian women. Some 280 women with breast cancer and who were nongene carriers of mutated BRCA gene were recruited as cases. Another 280 women, without any cancer and nongene carriers of mutated BRCA gene served as controls. A tested lifestyle questionnaire was interviewer administered to incident cases to obtain information on weight history, smoking, physical activity, and other lifestyle risk factors. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in logistic regression models. Comparing cases to controls, breast cancer risk was higher among subjects who reached their maximum body mass index (BMI) at an older age (>50 years) (OR = 2.83; 95% CI: 2.34–2.91). A positive association was noted between breast cancer risk and weight gain of >34 lbs compared to weight gain of ≤15 lbs, since the age of 20 (OR = 1.68; 95% CI: 1.10–2.58). Weight gain of >24 lbs compared to weight gain of ≤9 lbs, since the age of 30 also resulted in the same relationship (OR = 1.96; 95% CI: 1.46–3.06). Similarly, since the age of 40, weight gain of >12 lbs compared to weight gain of ≤1 lb was associated with increased breast cancer risk (OR = 1.91; 95% CI: 1.53–2.66). Women who smoked >9 pack-years of cigarettes had a 59% higher breast cancer risk (P = .05). Subjects who engaged in >24.8 metabolic-equivalent- (MET-) hours per week compared to ≤10.7 MET-hours per week of moderate physical activity had a 52% (P = .01) decreased risk and total physical activity between 16.2 and 33.2 MET-hours per week compared to ≤16.2 MET-hours per week, resulted in a 43% (P = .05) lower risk of breast cancer. In conclusion, weight history did affect breast cancer risk. Moreover, smoking appeared to raise the risk, whereas moderate physical activity had a protective effect.

Actividad física y riesgo de cáncer de mama en mujeres mexicanas

To evaluate the effect of moderate physical activity (hours per week and METs hours per week) on the risk of breast cancer (BC) in Mexican women. This is the initial stage of a case control multicentric study based in the Federal District, Monterrey and Veracruz, Mexico, during 2004. Fifty eight cases paired to 58 control cases on quinquennium of age, and belonging to the health system were analyzed: three hospitals from the IMSS, three from ISSSTE and three from SS participated. In postmenopausal women, there was a reduction of the risk in BC by every additional hour per week of moderate physical activity (RM= 0.91; IC95% 0.85-0.97); in premenopausal women, the reduction of the risk was not statistically significant (RM= 0.99; IC95% 0.94-1.05) (p= 0.048, effect modification). Moderate physical activity reduces the risk of BC in postmenopausal Mexican women.

Influence of Ageing on Monocarboxylate Transporter in Human Skeletal Muscle

Isoforms of the lactate transporter known as monocarboxylate transporter (MCT) are increased in skeletal muscle following vigorous exercise. To date, no studies have investigated how age influences the content of MCT1 and MCT4 in human skeletal muscle. PURPOSE: To test the hypothesis that, compared with the vastus lateralis (VL) of untrained subjects, the VL of endurance trained athletes would exhibit an increase in the content of MCT1 and MCT4. METHODS: Healthy male subjects (n=33) were recruited and assigned to one of six groups based on age and training status (young trained (YT), n=6, 23.2 ± 0.8 yr, young untrained (YUT), n=6, 22.3 ± 2.9 yr, middle-aged trained (MAT), n=6, 46.3 ± 4.3 yr, middle-aged untrained (MAUT), n=5, 44.6 ± 3.9 yr, senior trained (ST) n=6, 58.7 ± 3.4 yr, and senior untrained (SUT), n=4, 58.8 ± 1.9 yr. The inclusion criteria required that all trained subjects spend at least 8 hours per week training above 60% of their VO2max, and that all untrained subjects have a self-reported average of less than 3 hours per week of moderate physical activity. Assignment to training status was supported by the completion of a VO2max test, by the wearing of an Actiheart™ downloadable heart rate monitor to record daily heart rates, and by completing a physical activity questionnaire. Muscle biopsies of the VL were analyzed Western Blot for MCT1 and MCT4 content. RESULTS: There were no significant age-related differences in MCT1 or MCT4 content (Y vs. MA vs. S, P > 0.05), and no significant differences in MCT1 or MCT4 content related to training status were observed (T vs. UT, P > 0.05), although a trend toward decreased content of both isoforms was found in the untrained group when compared with the trained group. CONCLUSION: The results of this first study investigating an effect of age and training status on moncarboxylate transporters in human skeletal muscle suggest that age does not influence the level of lactate transporter proteins MCT1 and MCT4. Supported by a grant from The Gatorade Sports Science Institute.