Two different in-row soil management techniques were compared in the Olive Orchard Innovation Long-term experiment of the Council for Agricultural Research and Economics, Research Centre for Olive, Fruit, and Citrus Crops in Rome, Italy. Rows were managed with an in-row rotary tiller and with synthetic mulching using permeable polypropylene placed after cultivar Maurino olive trees planting. The effects of the two treatments were assessed through weed soil coverage and the growth of the olive trees. Results showed better agronomic performance associated with synthetic mulching. The weed control effect along the row of a young high-density olive orchard was higher with the synthetic mulching compared to hoeing. The effect of the synthetic mulching seemed to disappear when removed from the ground (spring 2023) since no significant differences were found for tree size and yield in the two tested in-row soil management systems at the end of 2023. Finally, the growth of the young olive trees (Trunk Cross Sectional Area, Height, and Canopy expansion) measured across the three years, was higher for the synthetic mulched row than the hoed one. The use of synthetic mulching along the row positively forced the vegetative growth of the young olive trees and anticipated the onset of fruit production compared to periodical hoeing: a significantly higher fruit production was registered three years after planting. Root diameter was higher under synthetic mulching one year after planting, and no differences were observed in the following sampling dates showing similar fluctuations linked to the seasonal growth pattern. The life cycle assessment and costing highlighted that the application of mulching had a higher eco- and economic-efficiency than the periodical in-row soil hoeing.