A field investigation was conducted during winter (rabi) season of 2021 at Agricultural Research Farm of Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, to study the efficacy of doses of 2, 4-D sodium salt 80% WP on weeds, productivity and economics of rabi maize (Zea mays L.). Application of 2, 4- D sodium salt 80% WP @ 1,250 g/ha at 25 days after sowing (DAS) resulted in to lesser weed density and weed dry weight of Physalis minima Roem. & Schult, Chenopodium album (L.), Melilotus indicus (L.) and Cichorium intybus (L.) as compared to 2, 4-D sodium salt 80% WP @ 1,000 g/ha and 2, 4-D sodium salt 80% WP @ 750 g/ha at 60 DAS, with higher weed control efficiency (77.3 %) and lesser weed index (34.9 %). At 60 DAS, 2, 4-D sodium salt 80% WP (applied @1250 g/ha at 25 DAS) produced higher plant height, number of leaves, chlorophyll content, leaf area index and plant dry-matter over other treatments except weed free and two hand weeding at 20 and 40 DAS. Application of 2, 4-D sodium salt 80% WP @ 1,250 g/ha at 25 DAS recorded higher number of cobs, number of kernels, number of kernels/row and seed index as compared to 2, 4-D sodium salt 80% WP @ 1,000 g/ha, and 2, 4-D sodium salt 80% WP @ 750 g/ha. Higher kernel (3.7 t/ha) and stover yield (4.7 t/ha) of maize was recorded due to application of 2, 4-D sodium salt 80% WP @ 1,250 g/ha at 25 DAS with higher harvest index (44.5%) and monetary returns (62.5 × 103 `/ha) as compared to 2, 4-D sodium salt 80% WP @ 1,000 g/ha, and 2, 4-D sodium salt 80% WP @ 750 g/ha.