Wechsler Adult Intelligence Scale-Revised Research Articles

Functional Neural Correlates of the WAIS-IV Block Design Test in Older Adult with Mild Cognitive Impairment and Alzheimer’s Disease

The Wechsler Adult intelligence scale-Revised (WAIS-R) Block design test (BDT) is a neuropsychological test widely used to assess cognitive declines in aging population. Previous studies suggest parietal lobe is the key region to influence the performance on the BDT; yet, it has not been clearly identified. The aim of the current study, therefore, is to identify the functional neural correlates of the BDT in older adults with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia patients. The current study includes 213 cognitively impaired mid to old-aged community dwelling Korean. All participants underwent comprehensive clinical and neuropsychological assessments and 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans. Performance on the BDT was assessed using the WAIS-IV Korean version. Voxel-wise analyses were used to investigate the correlation between regional cerebral glucose metabolism and BDT performance. The same analyses were conducted on the subgroups categorized by clinical severity based on the Clinical Dementia Rating (CDR). Significant positive correlations between performance on the BDT and regional cerebral glucose metabolism were found bilaterally in the inferior parietal lobules, right thalamus and right middle frontal gyrus. Our results suggest that performance on the BDT in MCI and AD patients functionally relies on the brain regions known to be associated with motor and executive functions in addition to visuospatial function.

Handedness, intelligence, visual-perceptual and motor functions in young adults

This study was conducted to investigate intelligence and visual-perceptual and motor functions in relation to hand dominance and the moderating role of gender and in young adults. The participants included 120 left-handed and right-handed individuals. A demographic questionnaire, the Wechsler Adult Intelligence Scale-Revised (WAIS-R) and the Bender-Gestalt II (BGT-II) were used for data gathering in this study. Analysis did not show any significant differences between left-handed and right-handed individuals in intelligence, performance and both recall and motor subscales of BGT-II in the present study. Findings showed significant group differences for the copy and the perceptual subscales of BGT-II in these samples. Left-handed individuals had significantly higher scores than right-handed individuals in the copy and the perceptual subscales of BGT-II. Also, there were no significant differences between males and females on the WAIS-R and all subscales of the BGT-II in this study. This study indicated the different effect of hand preference in intelligence and visual-perceptual and motor functions among young adults with the moderating role of age.

Relation of medication adherence to cognitive functions in egyptian patients with bipolar I disorder.

Nonadherence to medication regimens is frequently reported in bipolar I disorder (BDI) patients. However, little is known about the relationship between cognitive functions and adherence in BDI. To establish possible associations between medication adherence and cognitive function in patients with BDI. A total of 110 inpatients with BDI were subjected to the Structured Clinical Interview for DSM-IV Axis I Disorder, Morisky 8-Item Medication Adherence Scale, Young Mania Rating Scale, Wechsler Adult Intelligence Scale-Revised, Wechsler memory scale (WMS) and Wisconsin card sorting test (WCST). Patients were assessed on admission and followed up 6 months after discharge. Six months after discharge, (58.2%) of patients were nonadherent to their medications. The nonadherent group were younger males with less years of education, with lower mean scores in information orientation and visual memory backward domains of WMS and lower mean scores in perseveration responses, perseveration errors and learning to learn domains of WCST. In logistic regression analysis, younger age and impaired information orientation domain of WMS were putative predictors of nonadherence. Episodic memory and younger age were the strongest patients' related factors associated with nonadherence to medication. These results suggest that rehabilitation of specific cognitive skills may improve adherence in BDI.

Клинический случай человека с синдромом саванта из Турции: когнитивные функции и календарный расчет

The current study is the first detailed report on a savant case in Turkey. We collected data from a 25-year-old-male savant on attention span, short-term memory, working memory, autobiographical memory, overall intelligence, reading speed, text interpretation, and advanced calendar calculation. Data collection tools included the Test of Nonverbal Intelligence (4th edition), Wechsler Adult Intelligence Scale-Revised, Stanford-Binet 5 Working Memory Test and Raven's Colored Progressive Matrices for assessing general intellectual functioning; the Verbal Short-Term Memory Test for assessing memory assessment; d2 for assessing attention; a structured reading text; family interview protocols; and an individual interview protocol. The savant has a composite intellectual level of 85 and was recently diagnosed with pervasive developmental disorder when he was 25 years old. He evidenced limited attention span but excellent short-term memory, working memory, autobiographical memory and calendar calculation.

Correlates of Visuospatial Ability among Older People in Indonesia.

Introduction:The Indonesian elderly population keeps increasing. Aging is related with degeneration process, one of which is a decrease in cognitive function, including visuospatial ability. This is the first study on the visuospatial ability of Indonesian older people.Objective:This research aimed to assess the visuospatial ability and its correlation with sex, age, education, and general cognitive function among older people in Indonesia.Subjects and Methods:The research subjects were older people aged ≥60 years with Mini-Mental State Examination (MMSE) score ≥24. The visuospatial ability was assessed using Wechsler Adult Intelligence Scale-Revised (WAIS-R) Block Design Test (BDT). Regression analysis was performed to reveal the correlation of sex, age, education, and global cognitive function with visuospatial ability.Results:Sixty older people participated in this research, with an average age of 68.08 ± 6.24, mean MMSE score of 27.43 ± 1.71, and mean WAIS-R BDT score of 27.8 ± 7.27. The female and older individuals tended to have lower scores. Subjects with higher education and global cognitive function had higher WAIS-R BDT scores. Regression analysis showed that age and sex did not have significant effect, but education and global cognitive function had positive effect on visuospatial ability.Conclusion:There is a significant correlation between education and global cognitive function with visuospatial ability among older people in Indonesia.

Relationship between Deep White Matter Hyperintensities on Magnetic Resonance Imaging and Postoperative Cognitive Function Following Clipping of Unruptured Intracranial Aneurysm.

To evaluate the effects on cognitive function of deep white matter hyperintensities (DWMHs) on magnetic resonance imaging (MRI) in patients treated surgically for unruptured intracranial aneurysms (UIAs). The subjects were 106 patients in whom a Wechsler adult intelligence scale-revised (WAIS-R) examination was performed 1 week before and 1 month after clipping surgery for asymptomatic UIAs. DWMH severity was evaluated on preoperative MR images by Fazekas scale, as follows: none (absence), mild (punctate foci), moderate (beginning confluence of foci), or severe (large confluent areas). A decrease of 7 or more points in intelligence quotient (IQ) postoperatively was considered deterioration. Fazekas score was none in 41 (none group), mild in 42 (mild group), moderate in 21, and severe in 2 patients (moderate/severe group). Patient characteristics, surgical factors, IQ change, and abnormal findings on postoperative MRI were compared among the groups. Although there was no statistically significant deterioration in IQ postoperatively in any group, the percentage of deteriorated patients was significantly higher in the moderate/severe group (34.8%) than in the other groups (4.9% in the none group, 7.1% in the mild group; p <0.01, p <0.05, respectively). Brain injury was observed more frequently on postoperative MR images in the moderate/severe group (17.4%) compared with the none group (2.4%; p = 0.052). The presence of moderate/severe DWMHs was an independent prognostic factor for postoperative cognitive dysfunction. In conclusion, the presence of moderate/severe DWMHs was a prognostic factor for postoperative cognitive dysfunction after surgery for UIAs.

QOL-25. MICROSTRUCTURAL BRAIN CHANGES ASSOCIATED WITH NEUROCOGNITIVE AND FUNCTIONAL OUTCOMES OF INTRACRANIAL GERM CELL TUMUOR SURVIVORS – A DIFFUSIONAL KURTOSIS IMAGING STUDY

BACKGROUNDChildhood intracranial germ cell tumour (iGCT) survivors are prone to radiotherapy-related neurotoxicity which can lead to neurocognitive dysfunction. Diffusion kurtosis imaging (DKI) is a MRI technique that quantifies microstructural changes in the grey and white matter of the brain. This study aims to investigate the associations between MR-DKI metrics, the cognitive and functional outcomes of childhood iGCT survivors.METHOD20 childhood iGCT survivors who had received cranial radiotherapy were recruited. DKI parameters were determined for iGCT survivors and 18 control subjects. Neurocognitive assessment using the Hong Kong Wechsler Intelligence Scales for Children (HKWISC)/ Wechsler Adult Intelligence Scale – Revised (WAIS-R) and functional assessment using the Lansky/ Karnofsky performance scales were performed for GCT survivors.RESULTSThere were significant negative correlation between the IQ scores and the mean diffusivity (MD) in multiple white matter regions of iGCT survivors including: anterior limb of internal capsule, superior fronto-occipital fasciculus, anterior corona radiata, uncinate fasciculus, cingulum and hippocampus. Mean kurtosis (MK) values of the superior fronto-occipital fasciculus were positively correlated with IQ scores. For grey matter, the MD of the olfactory, insula, caudate, heschl gyrus, parahippocampal gyrus, hippocampus, anterior cingulum, frontal inferior operculum, middle and superior temporal gyrus, middle and superior frontal orbital gyri, cuneus and precentral gyrus were negatively correlated with IQ scores. Most of the microstructural changes with associated functional impairment were white matter regions.CONCLUSIONOur study identified vulnerable brain regions with significant white and grey matter microstructural changes that were associated with impaired cognitive function or deficits in physical functioning.

Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment.

Background: Stroke with basal ganglia damage (SBG) is a neurological disorder characterized by cognitive impairment. The neurobiological mechanism of cognitive impairment in stroke patients with basal ganglia damage (SBG patients) remains unclear. This study aimed to explore the underlying neurobiological mechanism of cognitive impairment in SBG patients using resting-state functional magnetic resonance imaging (rs-fMRI).Methods: The differences in functional connectivity (FC) between 14 SBG patients (average age: 61.00 ± 7.45 years) and 21 healthy controls (HC) (average age: 60.67 ± 6.95 years) were examined using voxel-mirrored homotopic connectivity (VMHC) and degree centrality (DC). Moreover, we compared the cognitive functions of SBG patients with HC using the Chinese Revised Wechsler Adult Intelligence Scale (WAIS-RC) and Wechsler Memory Scale (WMS).Results: Full-scale intelligence quotient (FIQ) (t = 2.810, p < 0.010) and memory quotient (MQ) (t = 2.920, p < 0.010) scores of SBG patients were significantly lower than those of HC. Compared with HC, significantly decreased VMHC values in the bilateral angular gyrus, supramarginal gyrus, inferior frontal gyrus, middle temporal gyrus, hippocampus, precuneus, precentral gyrus, and middle occipital gyrus and decreased DC values in the right supramarginal gyrus, bilateral angular gyrus, and right postcentral gyrus were observed in SBG patients. Moreover, the VMHC values in the angular gyrus, inferior frontal gyrus, supramarginal gyrus, and middle temporal gyrus and the DC values in the right supramarginal gyrus were significantly correlated with cognitive functions in all participants.Conclusion: Our findings may provide a neural basis for cognitive impairments in SBG patients. Furthermore, local abnormalities of functional networks and interhemispheric interaction deficits may provide new ideas and insights for understanding and treating SBG patients' cognitive impairments.

Cognitive correlates of borderline intellectual functioning in borderline personality disorder

Borderline intellectual functioning (BIF) is highly prevalent in patients with borderline personality disorder (BPD), but their relationship remains poorly understood. This retrospective study aimed to investigate the cognitive profile of BIF among people diagnosed with BPD. Clinical, demographic, and neuropsychological data of fifty-five outpatients with BPD were analyzed. The sample split into two groups: BPD with BIF (BIF+: n = 25; intelligence quotient – IQ - range: 71–84) and BPD without BIF (BIF-: n = 30; IQ range: 86–124). Between-group comparisons employed either parametric and non-parametric descriptive statistics, as necessary. Neuropsychological measures (Wechsler Adult Intelligence Scale-Revised – WAIS-R IQ, factor index, subtest scores) and cognitive performance deficits in the two groups were likewise compared aside, followed by Spearman's correlation test conducted on relevant metrics. The cognitive, but not the clinical and demographic profiles differed significantly between the two groups. BIF+ was associated with a specific pattern of verbal, attentive, and planning dysfunctions. The verbal comprehension index had the highest discriminative value for the presence of BIF in patients with BPD, and it was tightly associated with adaptive and social functioning. The neuropsychological assessment of BPD may be relevant to plan targeted interventions based on measures of cognitive functioning which could also serve to evaluate treatment efficacy and outcomes. Clinical implications and future directions are discussed.

Personality, emotional and cognitive functions in young adults born preterm

BackgroundSurvival of preterm very low birthweight infants resulted in high risk for developmental cognitive deficits, poor academic achievement, and behaviour disorders. While numerous studies evaluated the prevalence of neurodevelopmental disability in early childhood, poor literature is available for infants born very low birthweight in adulthood. Materials and methodsFifty-five young adults born preterm (mean age: 18 ± 2.42 years; <33 weeks of gestational age and/or with birth weight <1500 g) were enrolled. The Verbal Intelligence Quotient (vIQ), Performance Intelligence Quotient (pIQ) and Total Intelligence Quotient (tIQ) were assessed through the Wechsler Adult Intelligence Scale – Revised (WAIS-R). Personality profiles were investigated using Rorschach test. Both WAIS-R and Rorschach scores were subsequently compared to 13 matched controls born at term. Data were analysed with the SPSS v20 for Windows statistical package. ResultsYoung adults born preterm showed lower IQ scores than young adults born at term: tIQ 90.95 ± 22.46 versus 108.77 ± 16.14, p = 0.006; vIQ 89.85 ± 21.85 versus 107.69 ± 18.33, p = 0.009, and pIQ 92.40 ± 22.90 versus 108.31 ± 14.52, p = 0.011. No differences emerged in personality profile as most subjects showed adequate internal resources in both groups, but a trend towards anxiety and insecurity were identified in young adult born preterm. ConclusionsYoung adults born preterm show psychological fragility and lower cognitive pattern than young adults born at term. Data support the need of an early psychological intervention that could help these individuals at greater risk to face a young society that is changing and that necessarily requires stronger internal resources.

Theory of mind deficits in bipolar disorder in remission

Aims: Theory of Mind (ToM), a concept used to describe an individual's social cognitive abilities that play roles in social interaction, may have a significant role in explaining the clinical variables and social problems of affective disorders. This study aims to determine whether ToM functions are impaired in Bipolar Disorder (BD) compared to healthy controls as well as investigate the association between clinical variables of ToM deficit and social competence. Methods: A total of 50 patients diagnosed with BD who were in remission and 50 healthy control subjects were included in this cross-sectional study. Demographic data and medical history of participants were assessed, and Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Eyes test, Hinting Task, Social Adaptation and Self-Evaluation Scale (SASS), Wechsler Adult Intelligence Scale-Revised (WAIS-R) tests were administered. Results: There were no significant differences with regards to age, gender and BDI scores between patient and control groups. Hinting test (P=0.001), Eyes test (P=0.001), SASS (P=0.007) and WAIS-R (P=0.001) scores were higher in the control group. There was a significant correlation between Hinting Test and WAIS-R (r=0.430, P=0.001), and between Eyes Test and age (r.-0.590, P=0.001), duration of bipolar disorder (r=-0.554, P=0.001), number of manic attacks (r=0.590, P=0.001) and WAIS-R (r=0.343, P=0.050). Logistic regression analysis showed that compared to the patient group, control group was related to Eyes test by 1.2-fold for each point increase in Eyes test (P=0.001) and 1.3-fold for each point increase in Hinting test (P=0.003).Conclusion: ToM deficit was an essential factor that separated BD patients in remission from healthy individuals. ToM deficit may play a role in the essential pathology or affect the presence, or even onset, of BD.

The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer\u2019s Disease (TRC-PAD): Experience from the First 3 Years

BackgroundThe Trial-Ready Cohort for Preclinical and Prodromal Alzheimer’s disease (TRC-PAD) aims to accelerate enrollment for Alzheimer’s disease (AD) clinical trials by remotely identifying and tracking individuals who are at high risk for developing symptoms of AD, and referring these individuals to in-person cognitive and biomarker evaluation with the purpose of engaging them in clinical trials. A risk algorithm using statistical modeling to predict brain amyloidosis will be refined as TRC-PAD advances with a maturing data set.ObjectivesTo provide a summary of the steps taken to build this Trial-Ready cohort (TRC) and share results of the first 3 years of enrollment into the program.DesignParticipants are remotely enrolled in the Alzheimer Prevention Trials (APT) Webstudy with quarterly assessments, and through an algorithm identified as potentially at high risk, referred to clinical sites for biomarker confirmation, and enrolled into the TRC.SettingBoth an online study and in-clinic non-interventional cohort study.ParticipantsAPT Webstudy participants are aged 50 or older, with an interest in participation in AD therapeutic trials. TRC participants must have a study partner, stable medical condition, and elevated brain amyloid, as measured by amyloid positron emission tomography or cerebrospinal fluid analysis. Additional risk assessments include apolipoprotein E genotyping.MeasurementsIn the APT Webstudy, participants complete the Cognitive Function Index and Cogstate Brief Battery. The TRC includes the Preclinical Alzheimer’s Cognitive Composite, comprised of the Free and Cued Selective Reminding Test, the Delayed Paragraph Recall score on the Logical Memory IIa test from the Wechsler Memory Scale, the Digit-Symbol Substitution test from the Wechsler Adult Intelligence Scale-Revised, and the Mini Mental State Examination total score (1).ResultsDuring the first 3 years of this program, the APT Webstudy has 30,650 consented participants, with 23 sites approved for in person screening, 112 participants have been referred for in-clinic screening visits with eighteen enrolled to the TRC. The majority of participants consented to APT Webstudy have a family history of AD (62%), identify as Caucasian (92.5%), have over twelve years of formal education (85%), and are women (73%). Follow up rates for the first quarterly assessment were 38.2% with 29.5% completing the follow up Cogstate Battery.ConclusionsAfter successfully designing and implementing this program, the study team’s priority is to improve diversity of participants both in the APT Webstudy and TRC, to continue enrollment into the TRC to our target of 2,000, and to improve longitudinal retention, while beginning the process of referring TRC participants into clinical trials.

Analysis of EEG abnormalities of cognitive impairment and epileptic seizures in patients with epilepsy.

We conducted this study to analyze the EEG abnormalities of cognitive impairment and epileptic seizures in patients with epilepsy, as well as to investigate the application value of EEG in the diagnosis of epilepsy with cognitive impairment. 62 cases of patients that were admitted to our hospital for the first diagnosis as status epilepticus were selected. Of those, 20 cases were accompanied by cognitive impairment. The America Biology Graphene type 24 leads channel video EEG was applied to monitor staging, index, frequency, and distribution range of epileptic discharge. The revised Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC) and Wechsler Memory Scale-Revised in China (WMS-RC) were adopted to test cognitive function. The epileptic discharge index, discharge frequency and discharge distribution range of the conscious period, sleep I-II period and sleep III-IV period of epilepsy with the cognitive impairment group were evidently higher than those of epilepsy without cognitive impairment group. The differences were statistically significant (p<0.05). Intelligence Quotient (IQ) and Memory Quotient (MQ) level of the cognitive impairment group were the lowest in sleep III-IV period, with the next being the sleep I-II period; the highest was the conscious period, and the differences were statistically significant (p<0.05). With an increase of the epileptic discharge index, the discharge range, IQ and MQ level of cognitive impairment group decreased; differences were statistically significant (p<0.05). Therefore, the discharge index, frequency, and distribution range of epileptic discharge of epilepsy with cognitive impairment in different periods differed from epilepsy patients without cognitive impairment. According to the extent of cognitive impairment in different stages, discharge index, frequency, and distribution range were also different. The 24 h video EEG, which was used to monitor epileptic discharge characteristics, has a great application value for early identification of epilepsy with cognitive impairment.

Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder Offspring.

ObjectiveAltered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring.MethodsThirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance.ResultsHealthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance.ConclusionThe presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.

Comparing the North American Adult Reading Test (NAART) and the Test of Premorbid Functioning (TOPF) to estimate premorbid Wechsler Adult Intelligence Scale - 4th edition FSIQ in a clinical sample with epilepsy

Estimating premorbid general cognitive functioning is an essential component to the neuropsychological evaluation process. The North American Adult Reading Test (NAART) is a method to predict premorbid general cognitive functioning based on word reading skills developed using the Wechsler Adult Intelligence Scale-Revised (WAIS-R), which is currently in its fourth edition (WAIS-IV). The Test of Premorbid Function (TOPF) was developed using the WAIS-IV, based on the same method as the NAART, to estimate premorbid intellectual ability. There is a paucity of research comparing estimates of premorbid general intellectual ability between the NAART and TOPF. This study evaluated the clinical utility of premorbid estimates of FSIQ derived from the NAART and TOPF in a sample of 101 patients with temporal lobe epilepsy (TLE). Differences between NAART-derived premorbid FSIQs and TOPF simple demographic predicted FSIQs were significant (p < .001) with large effect sizes. NAART estimated premorbid FSIQ (M = 104.04, SD = 8.42) was significantly greater than TOPF premorbid estimates (M = 99.83, SD = 9.26). Results suggested NAART-derived estimates of premorbid FSIQ may be more accurate than TOPF-based estimates, which likely underestimated premorbid FSIQ in this sample of patients with epilepsy. Limitations and future directions are discussed.

Normative Data for Selected Subtests of the WAIS-R in a Spanish-Speaking Adult Population Living in the U.S. – Mexico Border Region

Abstract Objective Adaptations of the Wechsler Adult Intelligence Scale, Revised (WAIS-R) and accompanying norms exist for a limited number of Spanish-speaking populations, but none are available for US-dwelling Spanish speakers of Mexican origin, who make up the largest proportion of Latinas/os in the US. As part of a larger test adaptation and norming effort for Spanish-speakers from the US-Mexico border region, we generated and investigated demographically adjusted interpretive norms for selected WAIS-R subtests. Participants and Method Participants included 183 community-dwelling, primarily Spanish-speaking individuals, aged 20 to 55 (education range: 0-20 years; 58% female), who were residing in the US-Mexico border region. Participants completed the WAIS-R Spanish version (Block Design, Arithmetic, and Vocabulary subtests) as part of a larger neuropsychological battery. Demographically adjusted T-scores were calculated for these subtests using fractional polynomial equations, which controlled for age, education, and sex. We examined rates of neurocognitive impairment (T &amp;lt; 40) in our sample derived from the present demographically adjusted Spanish speaking norms and from the existing WAIS-R demographically adjusted norms for English-speaking Non-Latina/o White and Black adults. Results Based on the normalized distribution of T-scores, the newly developed regional Spanish-speaker norms yielded subtest rates of impaired performance between 13-16% (i.e., within the expected -1 SD). By comparison, the proportion of impaired subtest performances was between 4-6% when applying the existing English-speaking norms to our sample. Conclusions Regional normative data will improve interpretation of test performance on selected WAIS-R subtests for Spanish-speakers living in the US and will facilitate a more valid analysis of neuropsychological profile patterns in this population. Cross-validation with Spanish-speakers in other regions and/or with other national origins is needed.

Differences in the pattern of cognitive impairments between juvenile and adult onset myotonic dystrophy type 1

ObjectiveTo understand the different patterns of neuropsychological dysfunction observed between juvenile onset (jDM1) and adult onset (aDM1) myotonic dystrophy type 1. MethodWe enrolled 19 genetically confirmed DM1 patients, and neuropsychological tests—Wechsler Adult Intelligence Scale-Revised short form; Rey–Kim memory test; and Executive Intelligence Test for evaluating intelligence, memory, and executive function—were performed. Clinical parameters including cytosine-thymine-guanine (CTG) repeats, creatinine kinase level, pulmonary function test, six-minute walk test, motor scales, and cardiac function were evaluated. ResultsVerbal intelligence was significantly lower in the jDM1 than the aDM1 group (7.50 ± 1.64 vs. 11.00 ± 2.54, respectively; p = 0.009), while no difference was observed in performance intelligence. There was significant differences between the two groups (p = 0.022) with respect to memory function, as specifically revealed by the pattern of lower function in the verbal memory of the jDM1 group. However, the executive function test showed no intergroup differences. ConclusionVerbal memory impairment significantly deteriorated in the jDM1 group as compared to the aDM1 group, reflecting a more profound neurodevelopmental change in the juvenile type.

Co-treatment of buspirone with atypical antipsychotic drugs (AAPDs) improved neurocognitive function in chronic schizophrenia

We conducted a 24-week, randomized, double-blind parallel-controlled trial to test whether buspirone is beneficial to improve cognitive deficits of schizophrenia because it remains unclear. Two hundred patients received in random order either co-treatment buspirone with AAPDs or monotherapy with AAPDs. All patients had been treated with a stable dosage of AAPDs for at least three months. The positive and negative syndrome scale (PANSS), Hamilton Depression Scale-24 (HAMD-24), and 14-item Hamilton Rating Scale for Anxiety (HAMA-14) were used to evaluate clinical symptoms. The short version of Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC) was used to assess neurocognitive function. Social function and family burden were evaluated by Social Disability Screening Schedule (SDSS) and Family Burden Interview Schedule (FBIS). All patients were enrolled at baseline and followed up after 12 and 24 weeks. A total of 196 patients completed the trial, with 99 in the combined treatment group and 97 in the control group. During the intervention, the score of PANSS, HAMD-24, and HAMA-14 decreased slightly without group differences. Repeated measures ANOVA showed significant differences between the two groups in the score of arithmetic, similarities, picture completion, block design, SDSS, and FBIS (P < 0.05), but no difference was found with regard to the score of information, digital span test, or digital symbols (P > 0.05). In conclusion, co-treatment with buspirone and APPDs outperformed APPDs alone in improving cognitive deficit and reducing family burden of schizophrenia. Buspirone may be a promising candidate for co-treatment of schizophrenia-associated cognitive deficits.

Age Association Analysis between Tricarboxylic Acid Metabolites and Neurocognitive Impairment in Persons Living with HIV

ObjectiveInflammation may contribute to neurocognitive impairment (NCI) in people with HIV (PWH). Lipopolysaccharide‐mediated macrophage activation induces a shift from oxidative phosphorylation to glycolysis in‐vitro with accumulation of the tricarboxylic acid (TCA) metabolites succinate (SA) and citrate (CA). These metabolites engage diverse cellular inflammatory pathways and may indicate mitochondrial dysfunction. In this study, we developed and optimized an LC‐MS metabolomic method to allow the simultaneous detection and analysis of plasma SA and CA metabolites in in people with HIV.MethodsGeneralized estimating equations were used in a random sample of older PWH from the prospective, multicenter HAILO cohort. Plasma sample was mixed with methanol‐acetonitrile‐water (5:3:1) and 0.1mg/mL internal standard (ISTD, D4‐citric acid). The mixture was vortexed for 30 minutes and centrifuged at 10,000g for 10 minutes. The supernatants were dried, reconstituted in 0.2% formic acid/0.1mg/ml ISTD. Samples were analyzed using Kinetex ‐ C18 column coupled to an Agilent 6540 Q‐TOF LC‐MS. Metabolites identification was achieved based on retention time and product ions. Calibration curves were obtained by using SA and CA authentic standards spiked into 0.2% formic acid/0.1mg/mL ISTD. Using Agilent MassHunter Qualitative B.07 Software, the ratio of analyte and ISTD peak area was plotted against the corresponding concentration to obtain calibration curves. The peak area and the concentration of each analyte were determined using the peak area ratio. Neurocognition was assessed every 48 wks, where NCI was defined as ≥1 z‐scores ≥2 SD below 0 or ≥2 z‐scores ≥1 SD below 0 on Trailmaking A and B and the Wechsler Adult Intelligence Scale‐Revised Digit Symbol tests.Results200 participants were followed a mean ±SD of 160 ±51 wks with a mean of 4 ±1.1 assessments. The mean age was 51 ±7 yrs, 84% were men, 49% were white non‐Hispanic and 59% were current or past smokers. HIV‐1 RNA levels were &lt;400 copies/ml in 97% and the mean nadir and baseline CD4 counts were 234 and 664 cells/mm3, respectively. The mean education was 14 ±4 yrs and NCI was detected at entry in 53 participants (27%). Age modified associations between each metabolite and NCI (P=0.01 for interactions by age with each metabolite). A 1 SD increase of SA or CA levels associated with a 2.2 [95%CI 1.1, 4.3] or a 1.9 [1.3, 2.8] greater odds of NCI, respectively, in the oldest age‐tertile but not in younger age‐groups (Table).ConclusionAssociations between plasma TCA metabolite levels and NCI were evident among older PWH, possibly implicating inflammatory effects on neurocognition that associate with these metabolites or mitochondrial dysfunction and warrant further study.Support or Funding InformationNHLBI (K23HL116209) and NIAD (P30 AI036219)This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Relationship between intelligence quotient (IQ) and cerebral metabolic rate of oxygen in patients with neurobehavioural disability after traumatic brain injury

ABSTRACTObjective: Cerebral metabolism may play a significant role in neurobehavioural disability following traumatic brain injury (TBI). In this study, we examined the relationship between intelligence quotient (IQ) and the cerebral metabolic rate of oxygen (CMRO2) in the lateral prefrontal cortex, which was measured by 15O-labelled gas positron emission tomography (PET), in patients with TBI.Materials and methods: The subjects were 12 patients (eight males and four females) who suffered from neurobehavioural disability following TBI. Their mean age was 33.3 years. The cause of injury was traffic accidents in all patients and the mean period after injury was 44.8 months. These patients underwent 15O-labelled gas PET and tests using either the Wechsler Adult Intelligence Scale-Revised (WAIS-R) or the Wechsler Intelligence Scale for Children-Revised (WISC-R). Pearson’s correlation between CMRO2 and total IQ (TIQ) was calculated.Results: A statistically significant correlation was observed between TIQ and CMRO2 in the right Brodmann areas (BAs) 44 and 45. The lower the WAIS score, the higher the CMRO2 in both areas.Conclusion: Neurological function negatively correlated with the metabolism of oxygen. It was possible that changes in brain networks increased the neuronal activity in the undamaged areas and that the increased activity compensated for the function decline.