Database Website Research Articles

MRTF-A/SRF signaling suppresses invasion of oral squamous cell carcinoma.

Serum response factor (SRF) and myocardial-associated transcription factor-A (MRTF-A) had different regulatory effects on the tumorigenesis and development in different cancers. However, the role of MRTF-A/SRF in oral squamous cell carcinoma (OSCC) remains to be determined. CCK-8 assay, cell scratch experiment, and transwell invasion assay were conducted to investigate the effects of MRTF-A/SRF on biological behavior of OSCC cells. The expression pattern and prognostic value of MRTF-A/SRF in OSCC were analyzed based on cBioPortal website and TCGA database. Protein-protein interaction network was visualized to identify protein functions. Go and KEGG pathway analyses were performed to investigate related pathways. The effect of MRTF-A/SRF on epithelial-mesenchymal transformation (EMT) of OSCC cells was explored by western blot assay. Overexpression of MRTF-A/SRF inhibited the proliferation, migration, and invasion of OSCC cells in vitro. High expression of SRF was related to better prognosis of OSCC patients on hard palate, alveolar ridge, and oral tongue. Besides, overexpression of MRTF-A/SRF inhibited the EMT of OSCC cells. SRF was closely related to the prognosis of OSCC. High expression of SRF and its co-activator MRTF-A inhibited proliferation, migration, and invasion of OSCC cells in vitro, possibly via EMT suppression.

The Virtual Face of Colon and Rectal Surgery Training in the USA: An In-Depth Evaluation and Analysis of Fellowship Programs Website Content.

With an ever-evolving digital and virtual world hastened by the COVID-19 pandemic, prospective colon and rectal surgery fellowship applicants must rely on online sources of information, such as websites, rather than in-person visits to fellowship programs. This study analyzes and evaluates the content and accuracy of colon and rectal surgery fellowship program websites. The Fellowship and Residency Electronic and Interactive Database website provides a complete collection of colon and rectal surgery fellowship websites based in the USA. The accessibility of the websites was verified via Google search, and relevant content for the applicants was evaluated based on 50-point criteria. Analysis of 60 fellowship program websites was conducted, out of which only a fifth (20%) were kept up to date. Twenty-seven (45%) websites fulfilled 50% of the 50-point criteria. The most and least included data points were program overview (69%) and residential/housing information (24%). Most websites contained basic information relevant to international applicants but lacked crucial information such as visa sponsorship (12%) and city information (23%). An informative and easily accessible website is essential for prospective applicants to choose the best program for their career goals and academic needs. This study highlighted multiple areas for potential improvement in the colon and rectal surgery program websites. Individual colon and rectal surgery programs may benefit and attract more candidates to their programs through a fully optimized website design and content.

Temporal trends in acute myocardial infarction-related mortality in Italy (2007-2017)

Update data regarding acute myocardial infarction (AMI)-related mortality in Italy remain scant. We assessed AMI-related mortality and time trends in Italy from 2007 to 2017 by using the Eurostat Mortality Database. The vital registration data of Italy from the publicly free-available OECD Eurostat website database were analyzed for the period between January 1, 2007 and December 31, 2017. Deaths reporting the codes I21 and I22 were extracted and analyzed according to the International Classification of Diseases 10th revision (ICD-10) coding system. Joinpoint regression was used to calculate nationwide annual trends in AMI-related mortality, determining the average annual percent change with 95% confidence intervals (CIs). During the study period, 300 862 (132 368 men and 168 494 women) AMI-related deaths were recorded in Italy. Among 5-year age groups, AMI-related mortality increased with a seemingly exponential distribution. However, joinpoint regression analysis demonstrated a statistically significant linear decrease in age-standardized AMI-related mortality of -5.3 (95% CI -5.6, -4.9, p<0.0001) deaths per 100 000 individuals. A further sub-analysis, stratifying the population by gender, confirmed yielded results both in men (-5.7; 95% CI -6.3, -5.2, p<0.0001) and in women (-5.4; 95% CI -5.7, -4.8, p<0.0001). The Italian age-adjusted mortality rates for AMI decreased over time, both in men and women.

Sistem Informasi Monitoring Presensi Siswa SMP Negeri 3 Palopo Berbasis website

The problem that exists at SMP Negeri 3 Palopo Kota Palopo is that there is no information system used to convey information to subject teachers, homeroom teachers, and parents regarding student attendance, still using a manual system by recording attendance on paper. One way to reduce errors that occur is to create a website database that will store student attendance data so that the possibility of scattered data will be small, and many errors where still depend on pieces of paper as records, the impact of a manual attendance processing system causes the recapitulation process carried out by teachers in the field of study is less than optimal. In this way, information system design is expected to alleviate and prevent errors that often occur. The design of web-based attendance applications that utilize information technology, student attendance data allows it to be given directly to parents so that handling of problematic students based on attendance can be handled earlier. The concept offered is to provide a forum so that the school and parents can connect in real timeThe type of research used is Research and Development (R &amp; D) which has been developed based on needs. The R&amp;D (Research &amp;; Development) research method is used because this method is in accordance with the research objectives to be achieved, namely making a website-based attendance monitoring information system for SMP Negeri 3 Palopo students. The method used in this research process uses a waterfall approach or model or commonly called a waterfall. Because the purpose of this study is systematic or sequential. The information system in this study has been tested using blackbox testing techniques and the results can be concluded that all components in the system have run in accordance with their functions. The construction of this website as a student attendance monitoring information system at SMP Negeri 3 Palopo can help study teachers and homeroom teachers obtain accurate student attendance data information to help homeroom teachers convey attendance data information to parents better in the future

Investigation on the mechanism of Ginkgo Folium in the treatment of Non-alcoholic Fatty Liver Disease by strategy of network pharmacology and molecular docking.

Ginkgo Folium has a favorable effect on non-alcoholic fatty live disease (NAFLD), but its mechanism remains unclear. The aim of this study is to reveal the underlying mechanism of Ginkgo Folium in the treatment of NAFLD. Ingredients of Ginkgo Folium and ingredients-related genes were collected from TCMSP database and SwissTargetPrediction website, respectively. Genecards database was used to obtain NAFLD-related genes. Next, the protein-protein interaction network and key ingredients-genes network were constructed via Cytoscape3.7.0. Based on the Metascape website, gene ontology function analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were carried out for key genes. Finally, molecular docking was performed to present the interaction between components and genes using AutoDock Vina 1.1.2. Eighteen active ingredients and 10 target genes were screened from Ginkgo Folium. AKT1, TNF, EGFR, PTGS2, MAPK8, PPAγ, APP, ESR1, HIFα and PPAα were considered as potential therapeutic targets. These target genes were mainly enriched in insulin resistance, HIF-1, adipocytokine and AMPK signaling pathways. Molecular docking results suggested that Ginkgo Folium active ingredients including luteolin-4'-glucoside, sesamin, luteolin, chryseriol, isorhamnetin and laricitrin showed strong binding capacities with AKT1. The study showed that multi-components in Ginkgo Folium interacted with AKT1 and regulated AKT-AMPK/HIF pathway to alleviate NAFLD. Our findings provided an essential role and basis for new anti-NAFLD drug discovery and further research on Ginkgo Folium.

Pharmacological effects of baicalin in lung diseases.

The flavonoids baicalin and baicalein were discovered in the root of Scutellaria baicalensis Georgi and are primarily used in traditional Chinese medicine, herbal supplements and healthcare. Recently, accumulated investigations have demonstrated the therapeutic benefits of baicalin in treating various lung diseases due to its antioxidant, anti-inflammatory, immunomodulatory, antiapoptotic, anticancer, and antiviral effects. In this review, the PubMed database and ClinicalTrials website were searched with the search string "baicalin" and "lung" for articles published between September 1970 and March 2023. We summarized the therapeutic role that baicalin plays in a variety of lung diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis, pulmonary hypertension, pulmonary infections, acute lung injury/acute respiratory distress syndrome, and lung cancer. We also discussed the underlying mechanisms of baicalin targeting in these lung diseases.

Molecular diversity of 23-YSTR markers in Iraqi populations

Iraq is home to the ancient civilization, of Mesopotamia. The population genetics of Iraqis is important due to their ethnic diversity. This study aimed to analyze is to analyze the distribution of Y chromosome haplotypes in a sample of 680 native Iraqi males from regions of Iraq and compare it to previously published Y chromosome haplotype data from some neighboring Arab populations.In this study, A total of 680 unrelated samples (not belonging to the same nuclear family) of healthy males were sampled for the Y-STR analysis from the Iraqi populations in Baghdad. blood samples were collected at the ministry of health/medical legal Directorate/paternity and Baghdad from 2018 to 2020. Allele frequency and gene diversity were calculated. The Iraqi population data were compared with the neighboring populations using pairwise genetic distances using the Y Chromosome Haplotype Reference Database Website (YHRD) software.The discrimination capacity 23 STR loci provide was (0.92). The number of haplotypes observed in 680 samples, was 616 haplotypes (568 unique and 48 shared haplotypes). Haplogroup prediction suggests that haplogroup J1 is the most common in the Iraqi population, followed by J2. According to AMOVA and MD, showed high similarities with neighboring countries. We can conclude that there is no genetic structure among the populations and their data could be added to reference the Iraqi database.

Safety evaluation and whole genome sequencing for revealing the ability of Penicillium oxalicum WX-209 to safely and effectively degrade citrus segments

The microbial potential of Penicillium has received critical attention. The present research aimed to elucidate the efficacy of crude enzyme secreted from Penicillium oxalicum WX-209 in degrading citrus segments and evaluate the safety of the process. Results showed that citrus segment membranes gradually dissolved after treatment with the crude enzyme solution, indicating good degradation capability. No significant differences in body weight, food ingestion rate, hematology, blood biochemistry, and weight changes of different organs were found between the enzyme intake and control groups. Serial experiments showed that the crude enzyme had high biological safety. Moreover, the whole genome of P. oxalicum WX-209 was sequenced by PacBio and Illumina platforms. Twenty-five scaffolds were assembled to generate 36 Mbp size of genome sequence comprising 11 369 predicted genes modeled with a GC content of 48.33 %. A total of 592 genes were annotated to encode enzymes related to carbohydrates, and some degradation enzyme genes were identified in strain P. oxalicum WX-209. Data availabilityThe whole genome sequencing data in this study can be found in GenBank database of NCBI website with the accession number PRJNA 715321. The link: http://www.ncbi.nlm.nih.gov/bioproject/715321.

Facial action coding-based facial sub-structures for anxiety emotion classification

Most stroke patients usually have problems in communication and body movement, such as speaking, sitting, walking, and picking up items. Moreover, the number of caregivers is smaller than the number of stroke patients. Nevertheless, these patients need 24-hour caregivers for the patients’ safety. Therefore, the objective of this research is to determine patterns of anxiety emotion via facial expressions from the sub-structures on the face, such as the inner brow raiser, brow lower, lid raiser, and lip part. Random samples of 360 facial images from horror-thriller movies based on the internet movie database (IMDb) website were selected. Then, 68 facial landmarks for classifying the emotions were applied to each facial image. The differences in these 68 positions before and after the changed emotions were used as the emotional indicators. Furthermore, these different values are applied to implement a decision tree with all the boundaries of the sub-structures disclosed as a suitable classification model for emotion detection. Consequently, the accuracy when applying this decision tree with other facial images is 83.33%.

MP13-03 COMPLICATIONS ASSOCIATED WITH MINIMALLY INVASIVE SURGICAL THERAPIES (MIST) FOR SURGICAL MANAGEMENT OF BENIGN PROSTATIC HYPERPLASIA (BPH): A MANUFACTURER AND USER FACILITY DEVICE EXPERIENCE (MAUDE) DATABASE ANALYSIS

You have accessJournal of UrologyCME1 Apr 2023MP13-03 COMPLICATIONS ASSOCIATED WITH MINIMALLY INVASIVE SURGICAL THERAPIES (MIST) FOR SURGICAL MANAGEMENT OF BENIGN PROSTATIC HYPERPLASIA (BPH): A MANUFACTURER AND USER FACILITY DEVICE EXPERIENCE (MAUDE) DATABASE ANALYSIS João Porto, Ruben Blachman Braun, Dimple Chanamolu, and Hemendra Shah João PortoJoão Porto More articles by this author , Ruben Blachman BraunRuben Blachman Braun More articles by this author , Dimple ChanamoluDimple Chanamolu More articles by this author , and Hemendra ShahHemendra Shah More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003233.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: MAUDE database houses medical device reports of suspected device related complications received by Food and Drug Administration (FDA). In the present study we aim to evaluate the MAUDE database for reported complications of MIST procedures. METHODS: The FDA, MAUDE database website was queried using keywords: rezum, urolift, prostate artery embolization (PAE), transurethral needle ablation (TUNA), transurethral microwave therapy (TUMT), prostate stent and Temporarily Implanted Nitinol Device (ITIND) on 10/1/22. Details related to the device problem, complications, aborted/canceled procedures, use of anticoagulant drugs, blood transfusion, operative intervention, hospitalization were extracted from the cases. We used the Gupta classification system to stratify complications. Statistical analysis was performed with SPSS v.28. Chi-square was used to compare frequency of complications among surgical procedures. RESULTS: We found a total of 780 cases of MIST procedures and after removing irrelevant/no information (n=58) and duplicate cases (n=30), we included 692 cases. (Rezum-358, urolift-226, PAE-53, TUNA-31, TUMT-19, prostatic stent-4 and ITIND-1). Level I complications were commonest (62%) and most of these (95%) were related to devices. The screen display error was responsible for 93% and 83% aborted cases in rezum and TUNA, respectively. The PAE showed 40% of device component detachment/fracture. Most of the level II-III complications were not related to device or user (Table 1). Urolift had 49% of II-III complications, especially due to pelvic/retroperitoneal hematoma, which was associated with hospitalization and blood transfusion. There were 10 deaths reported after urolift, 2 after rezum and 1 after TUMT mostly due to cardiovascular events, which, according to the physicians involved, were not associated with the proposed treatment. CONCLUSIONS: Although MIST for BPH is a procedure with low complication rates, it is important to point out that adversities can happen. Our data should assist urologists and patients in selecting appropriate MIST procedure with shared decision-making process. Source of Funding: N/A © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e174 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information João Porto More articles by this author Ruben Blachman Braun More articles by this author Dimple Chanamolu More articles by this author Hemendra Shah More articles by this author Expand All Advertisement PDF downloadLoading ...

STRATEGIC SCENARIOS FOR SUSTAINABLE INDUSTRIAL DEVELOPMENT OF UKRAINE IN THE POST-WAR PERIOD

The purpose of the paper is to develop the most probable scenarios and to determine the strategic directions and effective tools for the Ukrainian industrial recovery, which will ensure the resistance of the economy in the conditions of military challenges. The method of strategic scenarios allows to find out how the industrial development in Ukraine will develop in the course of war and post-war recovery. Methodology. The methods of system analysis and logical modeling were used to describe the transition of the Ukrainian production from the current situation of military crisis to the target one; structural analysis was used to determine the system of indicators characterizing the resistance of the industry. For this purpose, national (State Statistics of Ukraine) and international (World Bank, Eurostat official website) databases characterizing the level and structure of industrial development in the last 5 years were used. The method of calculation takes into account the criteria of changes in indicators: direction (growth/decline occurred); rate of changes based on the cumulative annual growth rate for the period of 5 years. The study was carried out using analytical methods of the influence of trends in the formation of strategic scenarios in unpredictable situations (conditions of wartime uncertainty), to assess changes in the probability of occurrence due to the actual occurrence of one of them, which made it possible to identify trends, justify scenarios and take them into account when analyzing the prospects for industrial development to strengthen the defense capabilities and economic growth of Ukraine. The results of the survey showed that the strategic scenarios for the industrial development of Ukraine will be adjusted as necessary for the post-war industrial recovery in case of a long-term external military threat to preserve the state sovereignty. The achievement of the set strategic goals depends on the driving forces determining the industrial development in Ukraine. As the main indicators characterizing the tendencies of industrial development in Ukraine, the indicators reflecting the efficiency of the use of productive forces have been chosen: indicators of industrial production efficiency; labor productivity; indicators characterizing innovative development; performance indicators of foreign economic activity and investment development. Taking into account the influence of each of the driving forces of industrial development in the conditions of wartime uncertainty, three scenarios of industrial development were developed: a conditionally positive scenario, in which the economic system will gradually stabilize due to the cessation of hostilities and the recovery of production capacities; a conditionally negative scenario, which will be characterized by the disintegration of the economic system, the destruction of energy infrastructure facilities, where negative trends will dominate; a conditionally neutral (basic) scenario, in which the disintegration of the economic system will not reach extreme levels, and industrial production will develop in areas not covered by hostilities. Practical implications. The key problem of restoring economic stability in Ukraine is to create conditions for favorable development of industrial business, which depends on balanced strategic policy decisions. The transformation of industry into an effective force for the revival of the Ukrainian economy in the conditions of the war and post-war period requires a balanced strategic management of the future development, because it is crucial to meet the unprecedented demands of the war on the available resources of the country and to prevent a social, humanitarian, economic, financial, environmental, military crisis. At the same time, traditional methods of indicative planning cannot take into account all factors of wartime uncertainty, therefore, the rationale of future development vectors based on scenario planning makes it possible to create conditions for minimizing threats and realizing potential opportunities. Value/originality. Strategic scenarios provide for better economic recovery planning with long-term national priorities, development strategies of related industries and sectors for ensuring the Ukrainian manufacturing resistance.

Diseases and Treatment with NOA: Mini Review of Trauma Coagulopathy

Background: A key element of a geriatric patient is the problem of frailty. We generally identify a frail subject through sarcopenia, that is, the progressive reduction and thinning of the muscle mass. The sarcopenic subject falls because he cannot stand on his legs, including a whole series of endocrine, glucidic and neurological dysregulations that should have an extremely significant probability of falling. Objective: The purpose of this article is, starting from pharmacological aspects of noa, to evaluate how to deal with a traumatized patient in the treatment with noa. Methods: Both personal knowledge of pharmacology and the use of both paper books and international website databases such as pubmed, scopus, google scholar, researchgate were used to develop the article, typing in keywords such as "trauma coagulopathy" or "elderly patient treatment with noa" associated with specific compound names. Conclusions: In an elderly subject who reports a head injury, even a mild one, we may find a chronic subdural hematoma that is so easily achieved due to cerebral atrophy, the greater excursion of the brain into the skull that tears the subdural vessels. In addition, why frequently the elderly subject takes the antithrombotic drug: cardioaspirin, warfarin, but above all the new oral anticoagulants.

Antiphospholipid Syndrome and Pregnancy

Antiphospholipid syndrome is an autoimmune disease with a wide spectrum of manifestations from different organs, therefore it is challenging to diagnose. The disease presents antiphospholipid antibodies such as anticardiolipin antibodies (aCL), lupus anticoagulant (LA) and antiβ2-glycoprotein 1 antibodies (β2GPI). The most common symptoms include thrombosis in veins and arteries and obstretical complications such as early miscarriage, intrauterine fetal death, intrauterine growth restriction (IUGR), placental insufficiency, premature labor and eclampsia. To diagnose a patient with APS certain criteria have been chosen, where at least one clinical and one laboratory criterion must be present. In many cases it takes a lot of time before a proper diagnosis has been made, when a female patient presents obstretical complications. Adequate pharmacological treatment increases the odds of live birth rate from 20-30% to 70-80%. Scientific research shows correlation between antiphospholipid syndrome, infertility and premature ovarian insufficiency. Treatment mostly consists of heparin and low-dose aspirin, in certain cases hydrochloroquine is prescribed. Aside from pharamcological therapy, it is very important to minimize the effects of modifiable risk factors. The following article focuses on complications, diagnosing and therapy in pregnant women suffering from Antiphospholipid syndrome. All sources can be found in Pubmed’s website database.

Mare-MAGE curated reference database of fish mitochondrial genes

Biodiversity assessment approaches based on molecular biology techniques such as metabarcoding, RAD-seq, or SnaPshot sequencing are increasingly applied in assessing marine and aquatic ecosystems. Here we present a new reference database for fish meta-barcoding based on mitochondrial genes. The Mare-MAGE database contains quality-checked sequences of the mitochondrial 12S ribosomal RNA and Cytochrome c Oxidase I gene. All sequences were obtained from the National Center for Biotechnology Information- GenBank (NBCI-GenBank), the European Nucleotide Archive (ENA), AquaGene Database and BOLD database, and have undergone intensive processing. They were checked for false annotations and non-target anomalies, according to the Integrated Taxonomic Information System (ITIS) and FishBase. The dataset is compiled in ARB-Home, FASTA and Qiime2 formats, and is publicly available from the Mare-MAGE database website (http://mare-mage.weebly.com/). It includes altogether 231,333 COI and 12S rRNA gene sequences of fish, covering 19,506 species of 4,058 genera and 586 families.

Establishment of a new prognostic risk model of MAPK pathway-related molecules in kidney renal clear cell carcinoma based on genomes and transcriptomes analysis.

The mitogen-activated protein kinase (MAPK) signaling pathway is often studied in oncology as the most easily mentioned signaling pathway. This study aims to establish a new prognostic risk model of MAPK pathway related molecules in kidney renal clear cell carcinoma (KIRC) based on genome and transcriptome analysis. In our study, RNA-seq data were acquired from the KIRC dataset of The Cancer Genome Atlas (TCGA) database. MAPK signaling pathway-related genes were obtained from the gene enrichment analysis (GSEA) database. We used "glmnet" and the "survival" extension package for LASSO (Least absolute shrinkage and selection operator) regression curve analysis and constructed a prognosis-related risk model. The survival curve and the COX regression analysis were used the "survival" expansion packages. The ROC curve was plotted using the "survival ROC" extension package. We then used the "rms" expansion package to construct a nomogram plot. We performed a pan-cancer analysis of CNV (copy number variation), SNV (single nucleotide variant), drug sensitivity, immune infiltration, and overall survival (OS) of 14 MAPK signaling pathway-related genes using several analysis websites, such as GEPIA website and TIMER database. Besides, the immunohistochemistry and pathway enrichment analysis used The Human Protein Atlas (THPA) database and the GSEA method. Finally, the mRNA expression of risk model genes in clinical renal cancer tissues versus adjacent normal tissues was further verified by real-time quantitative reverse transcription (qRT-PCR). We performed Lasso regression analysis using 14 genes and created a new KIRC prognosis-related risk model. High-risk scores suggested that KIRC patients with lower-risk scores had a significantly worse prognosis. Based on the multivariate Cox analysis, we found that the risk score of this model could serve as an independent risk factor for KIRC patients. In addition, we used the THPA database to verify the differential expression of proteins between normal kidney tissues and KIRC tumor tissues. Finally, the results of qRT-PCR experiments suggested large differences in the mRNA expression of risk model genes. This study constructs a KIRC prognosis prediction model involving 14 MAPK signaling pathway-related genes, which is essential for exploring potential biomarkers for KIRC diagnosis.

Based on network pharmacology and bioinformatics to analyze the mechanism of action of Astragalus membranaceus in the treatment of vitiligo and COVID-19

Coronavirus disease 2019 (COVID-19) is spreading rapidly around the world. However, the treatment of vitiligo combined with COVID-19 has not been reported. Astragalus membranaceus (AM) has a therapeutic effect on patients with vitiligo and COVID-19. This study aims to discover its possible therapeutic mechanisms and provide potential drug targets. Using the Chinese Medicine System Pharmacological Database (TCMSP), GEO database and Genecards websites and other databases, AM target, vitiligo disease target, and COVID-19 related gene set were established. Then find the crossover genes by taking the intersection. Then use GO, KEGG enrichment analysis, and PPI network to discover its underlying mechanism. Finally, by importing drugs, active ingredients, crossover genes, and enriched signal pathways into Cytoscape software, a “drug-active ingredient-target signal pathway-” network is constructed. TCMSP screened and obtained 33 active ingredients including baicalein (MOL002714), NEOBAICALEIN (MOL002934), Skullcapflavone II (MOL002927), and wogonin (MOL000173), which acted on 448 potential targets. 1166 differentially expressed genes for vitiligo were screened by GEO. CIVID-19 related genes were screened by Genecards. Then by taking the intersection, a total of 10 crossover genes (PTGS2, CDK1, STAT1, BCL2L1, SCARB1, HIF1A, NAE1, PLA2G4A, HSP90AA1, and HSP90B1) were obtained. KEGG analysis found that it was mainly enriched in signaling pathways such as IL-17 signaling pathway, Th17 cell differentiation, Necroptosis, NOD-like receptor signaling pathway. Five core targets (PTGS2, STAT1, BCL2L1, HIF1A, and HSP90AA1) were obtained by analyzing the PPI network. The network of "active ingredients-crossover genes" was constructed by Cytoscape, and the 5 main active ingredients acting on the 5 core crossover genes acacetin, wogonin, baicalein, bis2S)-2-ethylhexyl) benzene-1,2-dicarboxylate and 5,2′-Dihydroxy-6,7,8-trimethoxyflavone. The core crossover genes obtained by PPI and the core crossover genes obtained by the "active ingredient-crossover gene" network are intersected to obtain the three most important core genes (PTGS2, STAT1, HSP90AA1). AM may act on PTGS2, STAT1, HSP90AA1, etc. through active components such as acacetin, wogonin, baicalein, bis2S)-2-ethylhexyl) benzene-1,2-dicarboxylate and 5,2′-Dihydroxy-6,7,8-trimethoxyflavone to activate IL-17 signaling pathway, Th17 cell differentiation, Necroptosis, NOD-like receptor signaling pathway, Kaposi sarcoma-associated herpesvirus infection, and VEGF signaling pathway and other signaling pathways to achieve the effect of treating vitiligo and COVID-19.

Perspectives of Dermatology Program Directors on the Impact of Step 1 Pass/Fail.

The shift of Step 1 to Pass/Fail has generated several questions and concerns about obtaining residency positions among allopathic and osteopathic students alike. Determining the perspectives of Dermatology Program Directors in regards to post-Step 1 Pass/Fail is critical for students to better prepare for matching into dermatology. After receiving Institutional Review Board (IRB) exemption status, the program directors were chosen from 144 Accreditation Council for Graduate Medical Education (ACGME) and 27 American Osteopathic Association (AOA) Dermatology programs using contact information from their respective online website databases. An eight-item survey was constructed on a three-point Likert scale, one free text response, and four demographic questions. The anonymous survey was sent out over the course of three weeks with weekly individualized reminder requests for participation. A total of 54.54% of responders had "Letters of Recommendation" in their top 3. Forty-five percentof responders had "Completed Audition Rotation at Program" in their top 3. And, 38.09% of responders had "USMLE Step 2 CK Scores" in their top 3. Approximately 50% of responders agreed that all medical students will have more difficulty matching dermatology. Based on the survey study, Dermatology program directors want to focus more on letters of recommendation, audition rotations, and Step 2 CK scores. Because each field seems to prioritize different aspects of an application, students should attempt to gain as much exposure to different fields such as through research and shadowing to narrow down their ideal specialties. Consequently, the student will have more time to tailor their applications to what residency admissions are looking for.

Characteristics of undergraduate and second speciality mental health programmes in Peru: a cross-sectional study

BackgroundThis study aims to describe the training offered and the availability of professionals required by the Ministry of Health for mental health problems management in the community.MethodsA cross-sectional study was carried out on the training offered in mental health in Peruvian universities. A search for programs was conducted using the University Information System database and universities' websites, as well as using the Ministry of Health's database on health personnel and data on the number of enrolled and current students provided by the University Information System database and the Transparency section of the universities.ResultsThere were 214 undergraduate, 55 specialty and 7 subspecialty programmes, of which 39%, 47% and 100%, respectively, were offered in the capital city. The duration ranged from 5 to 7 years for undergraduate programs and from 1 to 3 years for subspecialty and second specialty programs. The cost of undergraduate programs ranged from free of charge up to USD 6863.75 for the first semester of study. Second specialty programs ranged from 720 up to 11 986 USD and subspecialty programs ranged from 2267 up to 9138 USD, with medicine being the most expensive. On the other hand, there are a greater number of psychology students (n = 78 781) pursuing undergraduate studies than working professionals (n = 5368), while in the second specialty of psychiatry there are far fewer students pursuing the specialty (n = 67) than working professionals (n = 454).ConclusionsThe problem of professional training in mental health requires that the institutions involved in health and education develop policies to decentralize programs, communicate the demand for professionals in certain areas, make them accessible to the low-income population, respond to mental health problems and guarantee their quality. On the other hand, regarding the low number of mental health personnel working, it is suggested to increase the mental health budget to generate more mental health services and employment.

Prediction of movie success based on machine learning and twitter sentiment analysis using internet movie database data

&lt;span lang="EN-US"&gt;Nowadays, predicting the success of a new movie is a crucial task. In this work, the hybrid approach considers the movie features as well as sentiment expressed in the movie review to predict the success rate of a movie. Multiple movie features such as title, director, star cast, and writer. Are considered for prediction. The related raw data is collected from the internet movie database (IMDb) website and after pre-processing, the collected data is used to generate the supervised machine learning model. Different supervised learning models are compared and the one with the best results is used further. The mean squared error, root mean squared error and r2 score of the models generated are comparable with existing models. Further, sentiment analysis of the movie-related tweets is performed. The accuracy of best sentiment analysis model is 88.47%. Finally, the two models are combined to give the success prediction rating of new movies and the results of the hybrid model are encouraging. The proposed model may be used to find the top-rated movies of a particular calendar year.&lt;/span&gt;

The Effects of the Government Policies on the Spread of the COVID-19 Pandemic

The study aims to determine whether government policies to control population mobility have been successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic. Policies implemented by governments for controlling population mobility are identified with the Stringency Index prepared by Oxford University. Population mobility is observed through data provided by Google Community Mobility Report. The success of countries in the fight against the COVID-19 pandemic is measured by the Reproduction Rate. The intersection of valid data covering 104 countries is gathered from databases of relevant official websites for the period between the date of reaching the 100th cumulative case and the date 360 days later. The data is analyzed by conducting panel data analysis method to test the hypothesis. Results show that the Stringency Index demonstrating the stringency of government policies implemented by countries to prevent the spreading of pandemic affected human mobility dimensions significantly and reversely. Human mobility dimensions have a reverse and significant impact on staying at home at different levels at the 95% confidence interval. Furthermore, a significant relationship with a very small bi value (-0.00008) emerges between staying at home and the Reproduction Rate in the reverse direction.