An overview of an industrial approach to the aerostructural optimization of a large business jet is presented herein. The optimization methodology is based on the integration of aerodynamic and structural analysis codes that combine computational, analytical, and semi-empirical methods, validated in an aircraft design environment. The aerodynamics subspace is analyzed with a three-dimensional transonic small disturbance code capable of predicting the drag of a complete, trimmed aircraft within engineering accuracy. The design of the wing structure is accomplished using a quasi-analytical method that defines the layout of the ribs and geometry of the spar webs, spar caps, and skin-stringer panels, and predicts the wing flexural properties and weight distribution. In addition, the prediction of operating economics as well as the integrated en route performance is coupled into the scheme by way of fractional change functional transformations. To illustrate the automated design system capabilities, the methodology is applied to the optimization of a large business jet comprising winglets, rear-mounted engines, and a T-tail configuration. The aircraft-level design optimization goal in this instance is to minimize a cost function for a fixed range mission assuming a constant maximum takeoff weight.