Chromosomes have fascinated biologists ever since Boveri and Sutton formulated the Chromosomal Theory of Inheritance about a hundred years ago, and this year is characterized by world-wide celebrations of the 50th anniversary of the DNA double helix. Although many fundamental questions concerning chromosome structure, function and dynamics remain unanswered, there is ample reason for optimism. The availability of more and more sequence information (for an ever-increasing number of organisms) and the emergence of new and powerful techniques (such as live cell imaging and RNA interference) now set the stage for rapid progress towards a better understanding of the functional organization of the cell nucleus. The journal Chromosoma is dedicated to chromosome structure and dynamics, as well as the mechanisms that underlie the duplication, maintenance and expression of genomes in eukaryotic cells and organisms. Hence, it covers one of the most fascinating and rapidly expanding areas of contemporary research. Chromosoma was founded almost 60 years ago by Hans Bauer and was subsequently managed by Wolfgang Beerman (two pioneers of research on the polytene ‘giant’ chromosomes). For the past more than 20 years, Wolfgang Hennig has been the Chief Editor of this venerable journal, and I have now taken over this responsibility as of 1 August 2003. In contrast to my predecessors, research in my laboratory does not focus on Drosophila or polytene chromosomes (see http://www.biochem.mpg.de/nigg/home.shtml for a survey of our research activities). I am nevertheless honored to follow in the footsteps of the former Editors of Chromosoma and look forward to working for the future scientific success of this journal. To take over responsibility for a journal at a time when publishing is undergoing major changes is both an exciting and a difficult task. I have decided to accept this challenge in recognition of the standing, tradition and importance of Chromosoma. I am convinced that Chromosoma has the potential to develop into a first-class scholarly journal. In recent years, chromatin research and studies on the biology of the cell nucleus have seen important scientific developments. Studies on histone modifications, epigenetic mechanisms of inheritance, chromatin boundaries, dynamic aspects of intra-nuclear organization, chromosome segregation in mitosis and meiosis, and the regulation of gene expression through miRNAs and siRNAs (to name but a few key subjects) have provided a wealth of new information but also raised many intriguing questions. It is my hope that Chromosoma will play an important role in describing the development of these research areas in the years to come. As a first step towards achieving this goal, the “Aims and Scope” of the journal have been revised and several leading scientists have been recruited to the Editorial Board (see inside cover). At this point in time, I am particularly delighted to welcome Drs. Genevi ve Almouzni, John Diffley, Conly Rieder and Frank Uhlmann as new Associate Editors. In another new initiative, we look forward to publishing an increasing number of authoritative review articles from leading scientists in Chromosoma. Finally, on the technical side, Springer will soon be introducing “ManuscriptCentral”, a web-based electronic manuscript submission and tracking system (implementation scheduled for 1 January 2004). This will increase both the convenience and the speed of manuscript processing and should contribute to enhancing further the attractiveness of Chromosoma for prospective authors. Importantly, all the advantages of publishing in Chromosoma will remain unchanged (see inside cover): in particular, publication in Chromosoma does not entail any page charges and there are no charges for the reproduction of figures in color. I look forward to working with a team of dedicated Associate Editors and to receiving competent technical support from the Publisher. With their help, I aim to ensure ever-increasing scientific quality for Chromosoma for the benefit of authors and readers alike.
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