Most important supergene ore or mineral deposits are those of Al, Fe, Mn, Cu, Ni, Co, and residual minerals: Au, PGE, REE, Nb, W, Sn, Cr, Ti-minerals, phosphates, diamond. During earth history, directed trends of weathering are observed which depend on the following parameters: tectogenesis and morphogenesis, and evolution of the atmosphere and the biosphere. Several — at least three — cycles of weathering can be distinguished during Early Precambrian, Late Precambrian-Paleozoic, and Meso-Cenozoic times. The weathering cycle of the Mesozoic-Cenozoic times is described here. Each weathering cycle starts under special world-wide conditions which are marked by monotonous and flat relief, by greenhouse effect, and by an initial lateritic sequence followed by increasing differentiation of the weathering sequences. The initial lateritic weathering provokes the main process of rock decomposition developing profiles with a thickness of several tens of metres. The vertical and lateral variations of the profiles and, therewith, the quality pattern of ore deposits mainly depend on: 1. morphology and drainage during the initial weathering; low drainage activity which causes very thick saprolites with a lower smectitic and an upper kaolinitic zone. Optimal drainage restricts saprolite evolution favouring the formation of thick Box-horizons; 2. lateritic cementation by chemical displacement and neoformation of textures during a progressive stage of lateritisation; 3. Mid-Tertiary to Quaternary changes of climate and morphology produce a laterite degradation, followed by erosion and/or resedimentation accompanied by mainly lateral, mechanical and/or chemical displacement of element or mineral concentrations. The evolution of laterites on parent rocks with preconcentration of certain elements leads to their destruction and reorganisation of geochemical provinces in new supergene element associations by relative or absolute enrichment creating special supergene geochemical provinces.