In this study the influence of some meteorological variables on Ultra High Frequency (UHF) radio signals from Edo Broadcasting Service (EBS) in Benin City, South-South, Nigeria located within Latitude 6°20’17”N and Longitude 5°37’32”E was investigated. The measurements of the radio signal strength from EBS Television, transmitting at 743.25 MHz UHF and some meteorological variables (air temperature, atmospheric pressure and relative humidity) using the Digital Community-Access/Cable Television (CATV) analyzer and a self designed cost effective portable weather monitoring system were carried out simultaneously at a residential building within Benin City, in order to ascertain the influence of these meteorological variables on the signal strength. The measurements were done every eight hours (between 7am-8am, 3pm-4pm and 11pm-12am respectively) for a period of one year (2017). From the obtained results, it was inferentially observed that the radio signals was having inverse relationship with the air temperature, atmospheric pressure and the relative humidity; on the assumption that for any of the aforementioned meteorological variables, the others were observed constant. Statistically, the signal strength and these meteorological variables were having correlation values of -0.94, -0.92 and -0.96 for the air temperature, atmospheric pressure and the relative humidity respectively. These results obtained from this study should be taken into account by the management of radio communication systems for enhancement and planning purposes.