Based on the discrete phase mode (DPM) in Computational Fluid Dynamic (CFD) software Fluent, the numerical simulation and experimental study on erosion wear properties of a new nano ceramic coating for downhole cyclone were carried out under sand containing conditions of the produced liquid. The results showed that the maximum wear position of nano ceramic coating in the spiral flow channel in downhole oil-water separator was in the range of azimuth 108°∼144°, and the coating wear rate increased with the increase of inlet flow velocity. When the particle size of sand phase was less than 0.3 mm, the wear rate of nano ceramic coating on cyclone was greatly affected by the particle size. The wear rate decreased with the increase of particle size. When the particle size of sand phase was larger than 0.3 mm, the wear rate of nano ceramic coating was less affected by the particle size. At the same time, the sand phase mass fraction was in the range of 0.1%∼3%. With the increase of sand content in the produced liquid, the wear rate of the cyclone coating increased gradually.