Weak Correlation Research Articles

Assessment of knowledge, attitude, and practices towards food waste management among Nigeria dwellers

Annually, approximately 40 % of food intended for human consumption is either wasted or lost, contributing to increased hunger and global food insecurity. Nigeria faces challenges related to food insecurity and diseases, which are linked directly and indirectly to food waste. Although food waste is a complex issue, proactive steps can be taken to reduce it. Most often, food waste occurs towards the end of the production chain, particularly during meal preparation and consumption.Therefore, this study was conducted to evaluate the levels of knowledge, attitudes, and practices among households regarding food waste management in Nigeria. The aim was to identify the factors contributing to food waste generation, enabling the implementation of suitable corrective measures. A survey was conducted, engaging 401 households across six geographic regions of Nigeria, employing an online self-administered questionnaire. Statistical analysis was conducted using SPSS 20, with significance set at a p-value of less than 0.05.The majority of participants were male, under the age of 44, and had tertiary education. Findings indicated that most participants demonstrated a good level of knowledge and moderate attitude and behavior, except regarding inappropriate waste disposal. Nearly all respondents (97 %) were aware that infrequent waste disposal can attract flies, and 95 % recognized that inadequate disposal can lead to diseases. A significant proportion (72.5 %) strongly agreed that sufficient knowledge of food preservation could reduce waste, while 71 % believed improper disposal of food waste harmed the environment. Analysis of the relationship between the three variables of Knowledge, Attitude, and Practice (KAP) concerning food waste management revealed a weak positive correlation. These findings emphasize the need for sustainable improvement in knowledge and awareness of food waste management to positively influence attitudes and practices.

Machine Learning Techniques to Analyze the Influence of Silica on the Physio-Chemical Properties of Aerogels.

This study explores the application of machine learning techniques, specifically principal component analysis (PCA), to analyze the influence of silica content on the physical and chemical properties of aerogels. Silica aerogels are renowned for their exceptional properties, including high porosity, large surface area, and low thermal conductivity, but their mechanical brittleness poses significant challenges. The study initially utilized cross-correlation analysis to examine the relationships between key properties such as the Brunauer-Emmett-Teller (BET) surface area, pore volume, density, and thermal conductivity. However, weak correlations prompted the application of PCA to uncover deeper insights into the data. The PCA results demonstrated that silica content has a significant impact on aerogel properties, with the first principal component (PC1) showing a strong positive correlation (R2 = 94%) with silica content. This suggests that higher silica levels correspond to lower thermal conductivity, porosity, and BET surface area, while increasing the density and elastic modulus. Additionally, the analysis identified the critical role of thermal conductivity in the second principal component (PC2), particularly in samples with moderate to high silica content. Overall, this study highlights the effectiveness of machine learning techniques like PCA in optimizing and understanding the complex inter-relationships among the physio-chemical properties of silica aerogels.

Metabolic signatures of metabolites of the purine degradation pathway in human plasma using HILIC UHPLC–HRMS

The metabolic disorders in the purine degradation pathway have proven to be closely associated with several human diseases. However, the etiology is not yet fully understood. Profile assay of purine intermediates and uric acid involved in the metabolic pathway can provide additional insight into the nature and severity of related diseases. Purine metabolites are endogenous chemicals with high hydrophilicity, polarity, and similar structures, thus there is a great need for a specific method to quantify them directly in biological fluids with a short running time. Herein, eight purine degradation pathway metabolites, including xanthine, hypoxanthine, guanine, xanthosine, inosine, guanosine, adenosine and uric acid, in human plasma were quantitatively measured using hydrophilic interaction chromatography-tandem high-resolution mass spectrometry (HILIC-HRMS) in a short running time of 10 min. The method was systematically validated for specificity, linearity of the calibration curve, the limit of detection, the limit of quantification, the lower limit of quantification, precision, accuracy, extraction recovery, matrix effect, and stability. The results showed that the method was linear (R2 > 0.99), accurate (the intra- and inter-day recoveries of all analytes ranged from 90.0 % to 110.0 %), and precise (the intra- and inter-day precisions were less than 6.7 % and 8.9 %, respectively) with the lower limits of quantification ranging from 3 to 10,000 ng/mL. The extraction recoveries and matrix effects were repeatable and stable. All the analytes were stable in the autosampler and could be subject to three freeze-thaw cycles. The developed method was ultimately applied to 100 plasma specimens from healthy individuals. The results showed that the concentrations of different purine metabolites varied dramatically in plasma specimens. Diet and body mass index (BMI) were the most significant factors determining purine levels, followed by drinking and sex. Age, smoking and bedtime showed a very weak correlation with purine metabolism. The findings of the present work reveal the characteristics of purine metabolism in human plasma under non-pathological conditions. The results also highlight the factors that can cause changes in purine metabolism, which are useful in developing effective treatment strategies for metabolic disorders of purines, particularly for those caused by lifestyle factors.

Correlation between elevated neutrophil lymphocyte ratio, vasotropic inotropic score, cumulative fluid balance and level of reactive oxygen species in septic patients

Introduction. Reactive oxygen species (ROS) serve as a biomarker in sepsis, while neutrophil lymphocyte ratio (NLR), vasotropic inotropic score (VIS), and cumulative fluid balance (CFB) correlate with inflammation and mortality. Understanding the correlation between elevated ROS levels and these markers aids in prognostication.The objective is to study the correlation between the increased level of neutrophil/lymphocyte ratio, vasotropic and inotropic index, total fluid balance and reactive oxygen species level in patients with sepsis.Materials and methods. A prospective cohort study in RSUD Dr. Moewardi’s ICU/HCU from June to August 2023 employed univariate, bivariate (Spearman correlation), and multivariate logistic regression analyses.Results. Among 34 sepsis patients, NLR and VIS showed significant positive correlations on day one, and NLR, VIS, and FB on day three. Delta changes in NLR and VIS significantly correlated with ROS.Conclusion. NLR and VIS changes predict ROS levels, while CFB exhibits weak correlations, which deserve additional investigation. This underscores the importance of NLR and VIS as prognostic indicators in sepsis.

Scale-dependent effects of vegetation attributes and soil fertility on productivity in two temperate forests in Northeast China

Forests are rich in biodiversity and high in productivity, and understanding the relationship between biodiversity and productivity is critical to the sustainable management of forest ecosystems. Although biodiversity and other factors contribute to forest productivity to varying degrees, it is unclear whether spatial scale (or plot size) influences this relationship. In this study, we analyzed the impacts of biodiversity, trait composition, structural attributes, and soil fertility on forest productivity at three scales in two temperate old-growth forests. We found that structural attributes, including basal area and stand density, were positively correlated with productivity and were consistently the strongest drivers of productivity changes in both forest types. Trait composition had a weak direct positive correlation with productivity. Soil nitrogen had positive effects on productivity, and soil moisture content had negative effects, both of which increased with increasing plot size. Different results for the effect of biodiversity on productivity were found between the two forests. In the mixed broadleaved-Korean pine forest, diversity correlated positively with productivity, and the strength of the relationship increased with increasing plot size. In contrast, in the spruce-fir valley forest, diversity had a direct positive correlation with productivity at 10 m × 10 m, no significant effect at 20 m × 20 m, and a negative correlation at 30 m × 30 m. Our results suggest that the contribution of vegetation attributes and soil fertility to forest productivity varies with scale. Despite the fact that both the niche complementarity hypothesis and the mass ratio hypothesis act simultaneously in forests, they have limited effects on productivity. Stand structural attributes play a key role in elucidating the biodiversity-productivity relationships, and they may serve as a more significant regulator of forest productivity than diversity. At the same time, the role of soil fertility in regulating productivity cannot be ignored.

Menstrual Cycle Phases and Elite Female Soccer During Training: Exercise Load Perception and External Workload Monitoring

BACKGROUND: Female soccer has grown exponentially in the last years, however studies on women soccer players are very few compared with male ones and several inconsistencies are reported in the literature for female players. Physiological hormonal fluctuations during the different moments of menstrual cycle could have important implications on soccer performance, therefore, the aim of the present study was to investigate the impact of menstrual cycle phases on external and internal loads in elite women’ soccer players during an in-season training period, and to describe the internal-external training load relationship, in relation to different menstrual cycle moments. METHODS: 16 elite players from Italian soccer first division were monitored for 12 weeks. The main internal parameter (rate of perceived exertion - RPE), external variables (total time, total distance, high speed running - HSR, numbers of accelerations/decelerations) and session-RPE were collected during training sessions and analyzed trough a repeated-measures ANOVA to identify differences in the MC weeks. Menstrual cycle was monitored through daily questionnaires and was divided into four phases: menstruation week, pre-ovulation, post-ovulation, and pre-cycle. RESULTS: HSR and total distance were significantly lower during menstruation week than post-ovulation week (18318.70 ±1802.04 m vs 20358.41 ± 1639.27 m, respectively; p=0.022). A significant correlation was found in pre-cycle week between RPE and total distance (r=0.545; p=0.029), and between session-RPE with total distance (r=0.514; p=0.042) and total time (r=0.502; p=0.048). When considering the whole menstrual cycle, weak and moderate correlations were found for RPE and session-RPE with total time, total distance and HSR. CONCLUSION: Appropriate menstrual cycle monitoring is required for better interpretation of players’ response in elite women’s soccer training, given that during menstruation week, external load variables could be impaired. RPE and session-RPE values do not change statistically with changes in external variables, and their relationship showed unclear results, highlighting caution when interpreting them, and suggesting their use in combination with other parameters, especially during early follicular phase.

Instagram as medium of information on feminism for Indonesia’s youth

Feminism has been an integral part of Indonesia’s history, yet it is commonly misunderstood as a western concept, causing fundamentalist religious groups and right-wing parties to strongly reject feminism. Therefore, social media that offer feminist literacy content is highly important, especially for Indonesia’s youth, as it can provide much-needed information that is often deemed taboo. The purpose of this research is to answer three research questions: (1) What is the use most sought by the followers of the @indonesiafeminis Instagram account? (2) What is the gratification most obtained by the followers of @indonesiafeminis Instagram account? And (3) Is the level of congruence between uses sought and gratifications obtained correlated with the intensity of consuming the @indonesiafeminis Instagram account? Using a quantitative survey method on 165 active followers of the @indonesiafemis Instagram account, results show that: (1) Cognitive needs are the use most sought by @indonesiafeminis followers; (2) Cognitive needs are also the gratification most obtained by the followers, and; (3) There is a positive but very weak correlation between the congruence of the uses sought and gratifications obtained and the intensity of consuming the Instagram account. Therefore, it is crucial that the administrators of @indonesiafeminis focus on providing informational content that satisfies the cognitive needs of the followers. However, despite the correlation, other factors beyond the congruence of the uses and gratifications possibly have an impact to the media consumption intensity.

Kekulé Counts, Clar Numbers, and ZZ Polynomials for All Isomers of (5,6)-Fullerenes C52-C70.

We report an extensive tabulation of several important topological invariants for all the isomers of carbon (5,6)-fullerenes Cn with n = 52-70. The topological invariants (including Kekulé count, Clar count, and Clar number) are computed and reported in the form of the corresponding Zhang-Zhang (ZZ) polynomials. The ZZ polynomials appear to be distinct for each isomer cage, providing a unique label that allows for differentiation between various isomers. Several chemical applications of the computed invariants are reported. The results suggest rather weak correlation between the Kekulé count, Clar count, Clar number invariants, and isomer stability, calling into doubt the predictive power of these topological invariants in discriminating the most stable isomer of a given fullerene. The only exception is the Clar count/Kekulé count ratio, which seems to be the most important diagnostic discovered from our analysis. Stronger correlations are detected between Pauling bond orders computed from Kekulé structures (or Clar covers) and the corresponding equilibrium bond lengths determined from the optimized DFTB geometries of all 30,579 isomers of C20-C70.

Influence of an iron dextran injection in various diseases on hematological blood parameters, including serum ferritin, neonatal dairy calves

BackgroundFeeding milk substitutes with low iron content or whole milk without iron supplementation is considered a major factor in developing iron-deficiency anemia in neonatal dairy calves. Young calves are often supplemented with iron dextran injections on the first day of life to prevent anemia. However, the effects of preventive treatment and the presence of disease on serum iron (Fe) concentrations, serum ferritin levels, and hematological blood parameters during the early neonatal stages have not been examined in detail. Therefore, we examined and evaluated the effects of iron dextran injections and health status on the development of hematocrit (Ht), red blood cells (RBC), hemoglobin concentration (Hb), erythrocyte indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration), Fe, and serum ferritin concentrations in dairy calves within the first 10 days of life. The suitability of serum ferritin as a reliable indicator of anemia in very young calves was evaluated by correlating ferritin concentrations with known laboratory diagnostic parameters of anemia.ResultsIron supplementation significantly increased Fe levels (P = 0.048) but did not affect serum ferritin levels in neonatal calves. Fe concentrations were significantly lower in diseased than healthy calves (P = 0.0417). Iron supplementation significantly affected the health status, as observed in Ht (Ptreat=0.0057; Phealth=0.0097), RBC (Ptreat=0.0342; Phealth=0.0243), and Hb (Ptreat=0.0170; Phealth=0.0168). Serum ferritin levels did not significantly correlate with Fe levels. Both groups showed marked differences in ferritin levels, with the highest levels measured on day 2. Fe concentrations showed weak negative correlations with Hb and Ht levels on day 3 (ρ=-0.45; P = 0.0034 and ρ=-0.045; P = 0.0032, respectively). RBC count showed strong positive correlations with Hb and Ht levels (ρ = 0.91 and ρ = 0.93; P < 0.001).ConclusionIron dextran injections increased Fe concentrations but reduced Ht level, RBC count, and Hb level. The presence of diseases led to a reduction in Fe and higher values of Ht, RBC, and Hb in moderate disease than in severe disease. Due to physiological fluctuations during the first 3 days of life, serum ferritin level seems unuseful for evaluating iron storage before day 4 of life.

Effect of lamins and emerin on nuclear morphology and histological architecture in lung adenocarcinoma

Emerin and lamins not only influence nuclear morphology but are also involved in differentiation. We herein examined 82 resected cases of invasive lung adenocarcinoma using computer-assisted image analysis of nuclear morphology on Feulgen-stained and immunohistochemical sections of lamin A, B1, B2, and emerin (four proteins) to calculate the rank sum of the cell positivity rates for these four proteins. The rank sum of four proteins showed weak negative correlations with the nuclear area and perimeter and a weak positive correlation with the nuclear shape factor. Interestingly, the top three cases with the highest rank sum were papillary adenocarcinoma, and the bottom three cases were acinar adenocarcinomas containing cribriform patterns. We compared the rank sum for grading (differentiation: G1, G2, and G3) and predominant histological subtypes and found that the rank sum of G3 was lower than that of G1 and G2. Furthermore, the rank sum was lower for acinar adenocarcinoma with >20 % cribriform pattern (acinar+cribri) and solid adenocarcinoma than for lepidic and papillary adenocarcinoma. Individual examination of the four proteins revealed that emerin expression was lower in G3 than in G1, and lamin B2 expression was lower in G3 than in G1 and G2. Compared with lepidic adenocarcinoma, acinar+cribri showed significantly lower expression of all four proteins among histological subtypes. These data indicated that the expression of lamin A, B1, B2, and emerin was markedly decreased in poorly differentiated adenocarcinoma (i.e., G3), especially in acinar+cribri. Our data suggested that changes in these four proteins can not only affect nuclear morphology but also histological structure in lung adenocarcinoma.

How anatomical impairments found on CT affect perfusion percentage assessed by SPECT/CT scan?

CT images can identify structural and opacity alterations of the lungs while nuclear medicine's lung perfusion studies show the homogeneity (or lack of) of blood perfusion on the organ. Therefore, the use of SPECT/CT in lung perfusion scintigraphies can help physicians to assess anatomical and functional alterations of the lungs and to differentiate between acute and chronic disease. To develop a computer-aided methodology to quantify the total global perfusion of the lungs via SPECT/CT images and to compare these results with parenchymal alterations obtained in CT images. 39 perfusion SPECT/CT images collected retrospectively from the Nuclear Medicine Facility of Botucatu Medical School's Clinics Hospital in São Paulo, Brazil, were analyzed. Anatomical lung impairments (emphysema, collapsed and infiltrated tissue) and the functional percentage of the lungs (blood perfusion) were quantified from CT and SPECT images, with the aid of the free, open-source software 3D Slicer. The results obtained with 3D Slicer (3D-TGP) were also compared to the total global perfusion of each patient's found on their medical report, obtained from visual inspection of planar images (2D-TGP). This research developed a novel and practical methodology for obtaining lungs' total global perfusion from SPECT/CT images in a semiautomatic manner. 3D-TGP versus 2D-TGP showed a bias of 7% with a variation up to 67% between the two methods. Perfusion percentage showed a weak positive correlation with infiltration (p = 0.0070 and ρ = 0.43) and collapsed parenchyma (p = 0.040 and ρ = 0.33). This research brings meaningful contributions to the scientific community because it used a free open-source software to quantify the lungs blood perfusion via SPECT/CT images and pointed that the relationship between parenchyma alterations and the organ's perfusion capability might not be so direct, given compensatory mechanisms.

Global-scale ERA5 product precipitation and temperature evaluation

ERA5 (European Centre for Medium-Range Weather Forecasts Reanalysis Fifth Generation) is a significant dataset in climate reanalysis. Conducting a global-scale accuracy assessment and spatiotemporal distribution characteristic study of its temperature and precipitation data is crucial for gaining in-depth understanding of extreme climate changes. This study, based on CRU TS v4.04 (Climatic Research Unit Time-Series version 4.04) gridded data, employs multiple statistical indicators and detection metrics to assess the accuracy of the ERA5 temperature and precipitation dataset at a monthly scale over the past 70 years. Additionally, it utilizes Empirical Orthogonal Functions (EOF) to explore its spatiotemporal distribution characteristics. The results indicate that: (1) ERA5 demonstrates good consistency in most regions globally; however, the influence of uneven station density distribution results in weaker correlation in areas with sparse station density. (2) The accuracy of ERA5 data exhibits certain differences between the two periods (1950–1979, 1979–2019); with the overall performance of ERA5 temperature data near the Earth’s surface being better than that of precipitation data. (3) ERA5 precipitation data in the mid and low latitudes of the Southern and Northern Hemispheres exhibit characteristics of positive–negative distribution, while temperature data show an opposite distribution in the Northern and Southern Hemispheres (with a predominant pattern of warmer temperatures in the north and colder temperatures in the south). Additionally, the typical patterns for both variables occur in January and July each year. The above study will provide reference and insights for future climate change prediction and adaptation efforts.

Investigating the Nexus of E-governance, Democracy, and Sustainable Development: A Case Study of the Gambia

This study examined the intricate relationships among e-governance, democratic principles, and sustainable development in The Gambia. The study adopted a mixed-method research design. The population is 6,644, out of which a sample size (363) was determined using Krejcie and Morgan's (1970) [9] formula. A multistage sampling approach was used, including stratified sampling to select respondents from each stratum and a proportionate-to-size sampling technique to determine the respondents in each stratum. The quantitative findings reveal strong positive correlations between technological enhancement, digital service accessibility, and various dimensions of governance and development. In addition, e-participation is identified as a pivotal factor in addressing challenges and aligning with sustainable development goals. Challenges in e-governance and democracy exhibit positive but weaker correlations, prompting a call for targeted interventions. The unexpected negative relationship between democracy and sustainable development urges further research for nuanced policy considerations. Qualitative insights from senior government officials provide context, highlighting proactive government responses, underscoring SDGs integration, and revealing key challenges. Policy implications encompass strategic investments, e-participation promotion, targeted interventions, effective evaluation processes, SDGs alignment, and a holistic approach to sustainable development. The study advocates for a nuanced policy approach to leverage e-governance's positive impact while acknowledging the complex dynamics involving democracy, ultimately aiming to guide policymakers in fostering a conducive environment for holistic and sustainable societal advancement in The Gambia.

Effect of Tourniquet-Related Nerve Ischemia on Response to Handheld Nerve Stimulation in Ulnar Nerve Transposition.

Tourniquet-related nerve ischemia has been well studied in several reconstructive procedures, but the time-course of impaired response to intraoperative stimulation is unclear. The present study evaluated ischemic effects on conduction during ulnar nerve transposition and examined the relationship between intra- and pre- operative diagnostics. We hypothesized that intraoperative ischemia would have minimal impact on conduction. Thirty patients scheduled for anterior transposition were enrolled after preoperative examination, electrodiagnostic testing, and ultrasound. Demographic and symptom severity data were recorded. A handheld biphasic nerve stimulator was used intraoperatively to assess minimum amplitude and pulse duration needed for muscle response. Measurements were taken at 15-minute intervals after placement. Changes in threshold amplitude and pulse duration were calculated between each 15-minute interval; no significant difference was found in the change of either value (p = 0.70 and 0.178). A weak negative correlation existed between preoperative CMAP amplitudes and average intraoperative pulse duration, which increased to a moderate correlation when compared to 45-minute pulse duration (r=-0.62, p<0.01). Preoperative ulnar nerve cross-sectional area (CSA) demonstrated no significant correlation with average pulse duration but a moderate correlation with pulse duration at 45 minutes (r=0.63, p=0.01). Tourniquet use did not prevent effective intraoperative stimulation of the ulnar nerve for at least 45 minutes. The window for meaningful stimulation with tourniquet usage appears to be greater than previously thought. Preoperative nerve CMAP amplitude and CSA does appear to influence pulse duration required after 45 minutes of ischemia, suggesting that injured nerves are more susceptible to ischemia. 1.

From SPECT/CT towards absolute quantification? - the case of unilateral condylar hyperplasia of the mandible

BackgroundUnilateral condylar hyperplasia (UCH) of the mandible is a rare condition characterized by asymmetric growth of the mandibular condyles. Bone scintigraphy with SPECT(/CT) is commonly used to diagnose UCH and guide treatment. Still, varying results have been reported using the traditional threshold of 55%:45% in relative tracer uptake. While absolute quantification of uptake on SPECT/CT could improve results, optimal correction and reconstruction settings are currently unknown.MethodsThree anthropomorphic phantoms representing UCH were developed from patient CT volumes and produced using 3D printing technology. Fillable spherical inserts of different sizes (Ø: 8–15 mm) were placed in the condylar positions representing symmetrical and asymmetrical distributions. Recovery coefficients were determined for SPECT/CT using various reconstruction corrections, including attenuation and scatter correction (ACSC), resolution modeling (RM), and partial volume correction (PVC) using phantom measurements. Uptake ratios between condyles and condyle to clivus were evaluated. Finally, the impact of these correction techniques on absolute activity and diagnostic accuracy was assessed in a retrospective patient cohort for the diagnostic threshold of 55%:45%.ResultsThe activity was only partially recovered in all spherical inserts (range: 22.5–64.9%). However, RM improved relative recovery by 20.2–62.3% compared to ACSC. In the symmetric phantoms, the 95% confidence interval (CI) of condyle ratios included the diagnostic threshold (57.6%:42.4%) for UCH when using ACSC potentially leading to false positives, but not for ACSCRM datasets. Partial volume corrections coefficients from the NEMA IQ phantom was positionally dependent, with improvements seen performing PVC using coefficients derived from anthropomorphic phantoms. Retrospective application in a patient cohort showed only a weak linear correlation (R²: 0.25–0.67) and large limits of agreement (9.6–12.5%) between different reconstructions. Up to 44% of patients were reclassified using the 55%:45% threshold. Using clinical outcome data, ACSCRM had highest sensitivity (91%; 95% CI 59–100%) and specificity (66%; 95% CI 47–81%), significantly improving specificity (P = 0.038).ConclusionsAnthropomorphic phantoms were shown to be essential in determining optimal settings for acquisition, reconstruction, and analysis. SPECT/CT reconstructions with attenuation and scatter correction and resolution modeling are recommended and could improve specificity when using the 55%:45% threshold to assess condylar growth.

End Point Surrogacy in First-Line Chronic Lymphocytic Leukemia.

Surrogate end points are commonly used to estimate treatment efficacy in clinical studies of chronic lymphocytic leukemia (CLL). This patient- and trial-level analysis describes the correlation between progression-free survival (PFS) and minimal residual disease (MRD) with overall survival (OS) in first-line trials for CLL. First, patient-level correlation was confirmed using source data from 12 frontline German CLL Study Group (GCLLSG)-trials. Additionally, a joint-frailty copula model was fitted to validate correlation in the setting of targeted therapies (TT). Second, a meta-analysis of first-line phase III trials in CLL from 2008 to 2024 was performed. Treatment effect correlation was quantified from seven GCLLSG and nine published trials, using hazard ratios (HRs) for time-to-event and odds ratios for binary end points. The GCLLSG analysis set comprised 4,237 patients. Patient-level correlation for PFS/OS was strong with Spearman Rho >0.9. The joint-frailty copula indicated a weak correlation for chemotherapy/chemoimmunotherapy (C/CIT) with a tau of 0.52 (95% CI, 0.49 to 0.55) while the correlation was strong for TT (tau, 0.91 [95% CI, 0.89 to 0.93). The meta-analysis set contained a total of 8,065 patients including 5,198 (64%) patients treated with C/CIT and 2,867 (36%) treated with TT. Treatment-effect correlation of the HRs for PFS and OS was R = 0.75 (95% CI, 0.74 to 0.76, R2 = 0.56) while correlation of end-of-treatment MRD with PFS and OS was R = 0.88 (95% CI, -0.87 to 0.89; R2 = 0.78) and 0.71 (95% CI, 0.69 to 0.73; R2 = 0.5), respectively. Patient-level correlation was confirmed in the setting of TTs while treatment-effect correlation between PFS and OS remains uncertain. MRD response status showed a high treatment-effect correlation with PFS but not OS, with the caveat of a limited number of randomized trials with available MRD data.

The First Evidence of a Host Star Metallicity Cutoff in the Formation of Super-Earth Planets

Planet formation is expected to be severely limited in disks of low metallicity, owing to both the small solid mass reservoir and the low-opacity accelerating the disk gas dissipation. While previous studies have found a weak correlation between the occurrence rates of small planets (≲4R ⊕) and stellar metallicity, so far no studies have probed below the metallicity limit beyond which planet formation is predicted to be suppressed. Here, we constructed a large catalog of ∼110,000 metal-poor stars observed by the TESS mission with spectroscopically derived metallicities, and systematically probed planet formation within the metal-poor regime ([Fe/H] ≤−0.5) for the first time. Extrapolating known higher-metallicity trends for small, short-period planets predicts the discovery of ∼68 super-Earths around these stars (∼85,000 stars) after accounting for survey completeness; however, we detect none. As a result, we have placed the most stringent upper limit on super-Earth occurrence rates around metal-poor stars (−0.75 < [Fe/H] ≤ −0.5) to date, ≤ 1.67%, a statistically significant (p-value = 0.000685) deviation from the prediction of metallicity trends derived with Kepler and K2. We find a clear host star metallicity cliff for super-Earths that could indicate the threshold below which planets are unable to grow beyond an Earth-mass at short orbital periods. This finding provides a crucial input to planet-formation theories, and has implications for the small planet inventory of the Galaxy and the galactic epoch at which the formation of small planets started.

Validation of the dispositional adult hyperfocus questionnaire (AHQ-D)

Hyperfocus (HF), or intense, deep concentration on a task, has gained significant research attention in recent years, particularly in regard to clinical populations such as Attention-Deficit/Hyperactivity Disorder (ADHD). The present work aims to provide validation of the 12-item dispositional adult hyperfocus questionnaire (AHQ-D) as a quantitative metric of HF in adults. We preregistered the study design and hypotheses. We administered the AHQ-D and several additional questionnaires to 347 adults (mean ± SD age: 33 ± 11 years; 47% female). Exploratory factor analysis revealed high factor loadings (0.57–0.81) on a single HF factor; item response theory analysis suggested that the questionnaire items had high discrimination and covered a wide range of responses; and we report strong internal consistency metrics (Cronbach’s alpha 0.93, mean split-half reliability 0.93). Replicating our previous work, HF was positively correlated with Conners’ Adult ADHD Rating Scale (CAARS) scores (r(345) = 0.53), suggesting that HF may be related to ADHD traits (though in this sample we did not specifically recruit individuals with ADHD). The AHQ-D demonstrated the hypothesized convergent validity; HF on the AHQ-D was positively correlated with HF measured using a different HF scale (r(344) = 0.69), as well as flow (r(345) = 0.12) and mind wandering (r(345) = 0.39) scores. AHQ-D HF scores showed a weak negative correlation with grit (r(345) = − 0.29). Though there was a weak negative correlation between HF and social desirability response tendency (r(345) = − 0.24), suggesting that those who care more about what others think may report less HF, there was no relationship between HF and extrasensory perception beliefs (r(345) = 0.01), suggesting that participants were not simply biased in their response tendencies. Taken together, we demonstrate strong scale metrics for the AHQ-D, the expected convergent validity, and a general lack of response bias, in addition to replicating our previous association of HF with ADHD traits. We suggest that the AHQ-D can be confidently used in future work as a valid way to measure HF in adults.

Patient and physician expectations regarding disease and treatment of advanced HCC: The prospective PERCEPTION1 study

BackgroundWe aim to explore patient expectations regarding their treatments and prognosis in comparison to physicians' assessments in patients with advanced hepatocellular carcinoma (HCC) receiving systemic treatments. MethodsWe prospectively enrolled 205 patients in France and Belgium with BCLC B/C HCC receiving systemic treatment (NCT04823754). Patients completed a 28-question survey and Hospital Anxiety and Depression Scale (HADS), while physicians filled a 17-question survey after the initial consultation. Univariate and multivariate models were used to assess factors associated with concordant patient-physician responses, HADS, predicted (by physicians) and observed overall survival. ResultsPatients had a median age of 68 years with 75% of BCLC C HCC; 86.3% received atezolizumab/bevacizumab. 60% of patients didn't discuss life expectancy with the physician. 63% of the patients believed they had a life expectancy > 5 years. Among shared questions between patients and physicians, 36.4% of concordance was observed; major differences centered on life expectancy with patients more optimistic than physicians. A lower patient-physician concordance was seen with shorter-consultations (p=0.003), female physicians (p=0.02), BCLC C (p=0.03) and >100 HCC patients/year per physician (p=0.008). Compared to France, patients from Belgium have more satisfaction about the consultation (p<0.001) but were less optimistic about life expectancy. Using HADS, 52% of the patients have anxiety/depression that was correlated with AFP (p=0.03). The predicted median overall survival by physician was 18 months versus 13 months for the observed overall survival (weak correlation, ρ=0.31). ConclusionExpectations regarding systemic treatments for advanced HCC differ significantly between patients and physicians, showing notable variations across countries. Impact and implicationsThis multicentric prospective study, conducted in France and Belgium, focuses on patients with advanced HCC undergoing systemic treatments. The findings of our study underscore the disparities in expectations regarding systemic treatments for advanced HCC between patients and physicians, revealing also significant variations between France and Belgium. These results suggest the need for targeted interventions aimed at enhancing patients' comprehension of their disease and fostering better communication between patients and physicians Clinical trial numberNCT04823754

Achieving SOC Conservation without Land-Use Changes between Agriculture and Forests

Global land-use changes impact soil’s ability to perform essential functions. This study investigates whether soil organic carbon (SOC) can be conserved without altering land use in traditional farming systems and degraded natural forests, focusing on ‘disturbed’ agricultural soils and ‘undisturbed’ forest soils. We also examine the influence of dominant crops on SOC within the top 30 cm of soil in data-deficient regions of Nepal. Using a multi-stage cluster sampling design, we tested 12 regression models to identify the best relationships among variables such as SOC, soil bulk density (BD), pH, dominant crops, climate, topography, and management practices. Our analysis revealed similar SOC levels in both disturbed and undisturbed soils, indicating significant degradation in forested areas, whereas traditional farming systems could support SOC and preserve farm-based indigenous knowledge alongside food security. Further, SOC stocks varied significantly (p &lt; 0.05) across different cropping systems, suggesting that managing dominant crops could be a strategy to optimize SOC, with these crops serving as indicators. Additionally, our results show that the weak linear correlation between SOC and BD in regularly disturbed soils, such as farmlands, where anthropogenic activities frequently alter soil bulk density, may be misleading when estimating bulk density-dependent SOC. This finding suggests the need for further research into varying degrees of anthropogenic disturbance in soil to confirm these results. While the site-specific nature of the findings warrants caution with respect to generalization, they provide valuable insights for carbon monitoring, climate actions, ecosystem health, and land-use management in similar traditional farming systems and degraded forests, particularly in data-poor regions.