Weak Evidence Research Articles

Pain Mechanosensitivity in Individuals With and Without a History of Lateral Ankle Sprain: A Critically Appraised Topic

Clinical Scenario: Pain is a common symptom experienced by individuals who sustain an acute lateral ankle sprain and can continue to persist among those who develop chronic ankle instability. Most rehabilitation protocols for individuals with acute ankle sprains or chronic ankle instability focus on restoring physical impairments and have largely omitted any pain-relieving therapies. This impairment-based focus has led pain to be an understudied symptom among individuals with an ankle sprain history. Overlooking the role of pain has also left clinicians with little insight into whether pain experienced after an ankle sprain is local (i.e., peripheral sensitization) or widespread (i.e., central sensitization). Understanding the pain profiles for those with an ankle sprain history may represent an unexploited area for clinicians and future research to improve health outcomes for this patient population. Clinical Question: Is there evidence to suggest that pain mechanosensitivity levels are different between those with and without a history of lateral ankle sprain? Summary of Key Findings: The literature was systematically searched for Level 4 evidence or higher. The search yielded two cross-sectional case-control studies and one cross-sectional study that met the inclusion and exclusion criteria. Based on the available evidence, pain mechanosensitivity levels are lower across ligamentous stabilizers immediately after an acute ankle sprain and over lower extremity neuromuscular structures among individuals with chronic ankle instability. Clinical Bottom Line: There is weak evidence to support an ankle sprain history can affect local pain mechanosensitivity levels of structures surrounding the ankle but not at distant locations. Strength of Recommendation: Level 4 evidence is available according to the Center for Evidence-Based Medicine.

Investigating the effectiveness of commercially available mouthwash on SARS-CoV-2 in vivo using viable virus titre as the primary outcome. A randomised controlled trial.

This multi-arm, parallel group, single-blinded randomised controlled trial aimed to assess three commercially available mouthwashes effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript has been written in accordance with the CONSORT statement. Methods. Eligible participants were SARS-CoV-2 positive with a positive test in the last 72 h. All participants had mild to moderate symptoms and could provide five saliva samples over a 60 min period. Participants delivered a baseline saliva sample and then used a mouthwash as per manufacturer's instructions. They provided further saliva samples at minute 1, 10, 30 and 60. Participants were randomised to one of four groups; OraWize+, Total Care Listerine, Cool Mint Listerine and water (control). The lab-based research team were blind to the intervention. The research question was: can SARS-CoV-2 be rendered inactive in saliva by using a mouthwash and how long does this effect last? The primary outcome was the amount of viable infectious SARS-CoV-2 virus in the sample, compared to the baseline sample. The secondary outcome measure was the amount of genetic material from the SARS-CoV-2 virus in the sample, measured via PCR testing. Results. In total 100 participants were recruited (25 per group). Eight participants did not receive the allocated intervention and did not have saliva samples collected. There were no adverse events. In total 42 of the 92 participants had viable virus which could be cultured at baseline. Statistical analysis of the primary outcome was not advised due to the reduced level of viable virus at baseline and the positive skewness present in the distribution of log10(titre) data. Observational data of the primary outcome measure is presented. Analysis of the secondary outcome PCR measure showed that there was strong evidence for a decrease in SARS-CoV-2 RNA levels compared to water for all mouthwashes after 1 min, OraWize+ -0.49 (-0.92, -0.05), p-value 0.029, Cool Mint Listerine -0.81 (-1.25, -0.38), p-value<0.001, Total Care Listerine -1.05 (-1.48, -0.62), p-value<0.001. For the remaining timepoints there was generally no evidence of virus level reduction compared to water although there is weak evidence for a decrease at ten minutes using Total Care Listerine -0.44 (-0.88, 0.01), p-value 0.053. Conclusion. The three mouthwashes included in this trial observationally demonstrated a reduction in virus titre level 1 min after use, with virus levels normalising up to 60 min compared to the control. Although an interesting observation, this result could not be statistically analysed. Using the secondary outcome PCR measure all three included mouthwashes reduced virus levels compared to water at 1 min and these results were statistically significant. Clinically this result does not support the use of the included mouthwashes to reduce SARS-CoV-2 levels in saliva.

Intravenous Ketamine for Cancer Pain: A Single-Center Retrospective Analysis Comparing Fixed-Rate Versus Weight-Based Dosing

Although weak evidence exists to support subanesthetic ketamine for cancer pain treatment, successful use may be hindered in the absence of standardized dosing guidance. We aimed to compare the success rates of intravenous ketamine fixed-rate versus weight-based dosing strategies for cancer pain treatment, and to assess patient characteristics that correlate with treatment success. We conducted a single-center retrospective review including non-critically ill adults with cancer pain who received subanesthetic ketamine for at least 24-h. All patients received fixed-rate ketamine; weight-based doses were retrospectively determined using total body weight. Treatment was considered successful if after reaching the maximum prescribed ketamine dose the patient had a 30% reduction in: baseline pain score, as-needed opioid use, or total morphine equivalent daily dose over a standardized 24-h. Of 105 included patients, 51 (48.6%) successfully responded to ketamine. Responders had lower fixed-rate ketamine doses compared to non-responders (median[IQR] 15 mg/hr[10-15] vs. 15 mg/hr[15-20], p = 0.043), but no difference in retrospectively calculated weight-based doses (0.201 ± 0.09 mg/kg/hr vs. 0.209 ± 0.08 mg/kg/hr, p = 0.59). Responders had higher daily opioid requirements at baseline compared to non-responders (p = 0.04). Though underpowered, our findings suggest that weight-based ketamine dosing may not convey additional benefit over fixed-rate dosing.

Reassessing the evidence on factor and portfolio premia

Abstract Using the modelling and estimation framework of W. Cao, C. Hurvich and P. Soulier (2017), we perform a test of the mean ( T 2 {T_{2}} statistic) for a large collection of daily Fama–French factors and portfolio returns, and compare the results with those based on the standard t test. The T 2 {T_{2}} -based results provide clearly weaker evidence in favor of various premia and in some cases suggest their absence. On the US market, the discrepancy between the tests is particularly large for the momentum factor. Caution should be exercised when assessing the presence of a given premium with the t test.

Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study

BackgroundCurrent guidelines recommend using antifungals for selected patients with health care-associated intra-abdominal infection (HC-IAI), but this recommendation is based on a weak evidence. This study aimed to assess the association between early empirical use of antifungals and outcomes in intensive care unit (ICU) adult patients requiring re-intervention after abdominal surgery.MethodsA retrospective, multicentre cohort study with overlap propensity score weighting was conducted in three ICUs located in three medical institutions in France. Patients treated with early empirical antifungals for HC-IAI after abdominal surgery were compared with controls who did not receive such antifungals. The primary endpoint was the death rate at 90 days, and the secondary endpoints were the death rate at 1 year and composite criteria evaluated at 30 days following the HC-IAI diagnosis, including the need for re-intervention, inappropriate antimicrobial therapy and death, whichever occurred first.ResultsAt 90 days, the death rate was significantly decreased in the patients treated with empirical antifungals compared with the control group (11.4% and 20.7%, respectively, p = 0.02). No differences were reported for the secondary outcomes.ConclusionThe use of early empirical antifungal therapy was associated with a decreased death rate at 90 days, with no effect on the death rate at 1 year, the death rate at 30 days, the rate of re-intervention, the need for drainage, and empirical antibiotic and antifungal therapy failure at 30 days.

Calendar versus Analysis Time: Reanalyzing the Relationship between Humanitarian Aid and Civil Conflict Duration

Abstract Previous work in International Studies Quarterly shows higher levels of humanitarian aid prolong civil conflicts. It also finds, among conflict–years in which aid is received, that this conflict-prolonging effect is more acute in insurgency-based civil conflicts, albeit with weaker supporting evidence. However, I show this work accidentally generated its conflict duration variable incorrectly, with the duration measuring time since January 1, 1960, not time since civil conflict onset. The duration values also exclude the first at-risk day for the first observation in each conflict, which drops true one-day durations from the estimation sample. I rerun the original analysis with the corrected duration coding and find evidence that supports the opposite of the author's main hypothesis: higher levels of humanitarian aid either have no effect on or shorten civil conflict duration. Additionally, the weak evidence for the author's second hypothesis mostly disappears, depending on the conflict's duration.

Long-Term Safety of Level II Oncoplastic Surgery after Neoadjuvant Treatment for Locally Advanced Breast Cancer: A 20-Year Experience.

Background: Oncoplastic surgery (OPS) reliability in the post-neoadjuvant chemotherapy (NACT) setting is still debated due to weak scientific evidences in such scenarios. Methods: Our analysis aims to report results obtained in a retrospective series of 111 patients consecutively treated with level II OPS after NACT at the Multidisciplinary Breast Center of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS between 1998 and 2018. The surgical endpoints were the mean specimen volume, rates of positive margins (PMR), re-excision (RR), conversion to mastectomy (CMR), and complications (CR). The oncological endpoints were overall survival (OS), disease-free survival (DFS), and local recurrence (LR). To evaluate the impact of NACT on surgical and oncological outcomes at 302 months, we conducted a propensity score matching, pairing patients in post-NACT and upfront surgery groups. Results: The mean sample volume was 390,796 mm3. We registered a 3.6% of PMR, 1.8% RR, 0.9% CMR, 5% CR. The 10-year OS and 10-year DFS with a median follow-up of 88 months (6-302) were 79% and 76%, respectively, with an LR recurrence rate of 5%. The post-NACT group received significantly larger excised volumes and lower PMR. NACT did not affect surgical and oncological outcomes. Conclusions: Level II OPS can be considered a reliable alternative to mastectomy even in the post-NACT setting.

Insider opportunistic trading through fast sales: Evidence from China

Using a sample of insider sales from firms listed on China's A-share market from 2010 to 2023, we provide robust evidence that insiders engage in fast sales when stocks have better pre-sale performance, compared to slow sales. Additionally, these fast sales predict lower abnormal returns in both the short and long term. Insider opportunistic trading through fast sales is more prominent in firms with high levels of information asymmetry and among insiders facing intense information competition. We find weak evidence that independent directors, institutional investors, and analyst coverage play a role in reducing such insider opportunistic trading. Finally, insider opportunistic trading through fast sales also predicts subsequent stock price crashes and extremely negative earnings news. Our findings help decipher the information content of insider sales in China's market.

Do flower-colonizing microbes influence floral evolution? A test with fast-cycling Brassica.

Pollinators are thought to be the main drivers of floral evolution. Flowers are also colonized by abundant communities of microbes that can affect the interaction between plants and their pollinators. Very little is known, however, about how flower-colonizing microbes influence floral evolution. Here we performed a 6-generation experimental evolution study using fast-cycling Brassica rapa, in which we factorially manipulated the presence of pollinators and flower microbes to determine how pollinators and microbes interact in driving floral evolution. We measured the evolution of 6 morphological traits, as well as the plant mating system and flower attractiveness. Only one of the 6 traits (flower number) evolved in response to pollinators, while microbes did not drive the evolution of any trait, nor did they interact with pollinators in driving the evolution of morphological traits. Moreover, we did not find evidence that pollinators or microbes affected the evolution of flower attractiveness to pollinators. However, we found an interactive effect of pollinators and microbes on the evolution of autonomous selfing, a trait that is expected to evolve in response to pollinator limitations. Overall, we found only weak evidence that microbes mediate floral evolution. However, our ability to detect an interactive effect of pollinators and microbes might have been limited by weak pollinator-mediated selection in our experimental setting. Our results contrast with previous (similar) experimental evolution studies, highlighting the susceptibility of such experiments to drift and to experimental artefacts.

The European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment

Objectives This survey assessed psychiatry residents’/early-career psychiatrists’ attitudes towards the utility of therapeutic drug monitoring (TDM) of antipsychotics. Methods A previously developed questionnaire on attitudes on TDM utility during antipsychotic treatment was cross-sectionally disseminated by national coordinators between 01/01/2022–31/12/2023. The frequency of using TDM for antipsychotics other than clozapine was the main outcome in a linear regression analysis, including sex, clinical setting, caseload, and factors generated by an exploratory factor analysis. Comparisons between residents and early-career psychiatrists, respondents working in in- and outpatient settings, and low-/middle- and high–income countries were performed. Results Altogether, 1,237 respondents completed the survey, with 37.9% having never used TDM for antipsychotics. Seven factors explained 41% of response variance; six of them were associated with frequency of TDM use (p < 0.05). Items with highest loadings for factors included clinical benefits of TDM (factors A and E: 0.7), negative expectations for beliefs of patients towards TDM (factor B: 0.6–0.7), weak TDM scientific evidence (factor C: 0.8), and TDM availability (factor D: −0.8). Respondents from low-/middle-income countries were less likely to frequently/almost always use TDM compared to high-income countries (9.4% vs. 21.5%, p < 0.001). Discussion TDM use for antipsychotics was poor and associated with limited knowledge and insufficient availability.

Anthropogenic influences on the extremely dry and hot summer of 2020 in Southern China and projected changes in the likelihood of the event

During summer 2020, Southern China experienced an extremely dry and hot summer, which was identified as one of the top ten domestic weather and climate extreme events in 2020 by China Meteorological Administration. Summer mean precipitation, surface air temperature (TAS), and number of hot days (NHD) were about 25% dryer, 1.5 °C warmer, and 11 days larger than the 1981–2010 climatologies. These are the 4th largest precipitation deficit, the highest TAS, and the 2nd highest NHD in the 1961–2020 record. The large-scale circulation anomalies over the West Pacific increased the likelihood of the extreme hot and dry summer. Anthropogenic influences on this extreme summerwere investigated using 525-member ensembles of the atmosphere-only HadGEM3-GA6 model and the multi-model ensembles from the Coupled Model Intercomparison Project Phase 6 (CMIP6). Anthropogenic forcings doubled (increased by 27%) the probability of precipitation deficits, and increased occurrence more than 106 times for both TAS anomaly (50 times probability higher) and NHD anomaly (6 times probability higher) in HadGEM-GA6 (CMIP6). That means that the 2020-like TAS and NHD anomalies would not occur without anthropogenic forcings, and there is weak evidence that human influences decrease rainfall over Southern China. However, the precipitation deficit increased the likelihood of exceeding the observed thresholds for both TAS and NHD by about 17 (4) and 9 (1) times in HadGEM3-GA6 (CMIP6), respectively. Under SSP2-4.5 and SSP5-8.5 scenarios in the future, 2020-like hot but wet extreme summer increases in magnitude and frequency, while the frequency of dry summer declines.

One shot-proteomic profiling, allergenicity assessment and varietal discrimination of lentils seeds by discovery high resolution tandem mass spectrometry

Lentils (Lens culinaris) represent important food staple replacing meat products in human diet with various applications of foods and feeds due to the high protein content. This work reported on the comparative proteomic profiling of four lentils commercial varieties Crimson, Eston, Laird and Black, providing novel knowledge on the differential expression of specific protein accessions with specific focus placed on the major protein families also investigating their allergenicity risk. The electrophoretic profile of lentil extracts confirmed that most of the proteomic profile was conserved across the investigated varieties, with only few differences highlighted for convicillin, vicilin and legumin subunits. A more in-depth analysis was carried out by one-shot discovery proteomics and provided the unequivocal identification and label-free quantification of 365 protein entries ranked into the main protein families. Statistically significant differences were disclosed for most of these protein groups and/or subgroups, cupins being the major contributors to the protein profile for all lentil samples. Noteworthy, the 7 S/11 S ratio describing seed nutritional quality highlighted clear differences among the four varieties with highest values reported for Eston and Laird samples. However, such higher nutritional quality was offset by a higher risk of allergenicity for sensitized individuals; indeed, the in-silico allergenicity prediction reported that most of the identified proteins presented either strong or weak evidence of immunogenicity with highest abundance in the Eston and Laird lentil samples. In perspective, the differential expression of specific protein accessions suggested the possibility to identify protein markers for varietal discrimination: a preliminary multivariate statistical analysis was accomplished to this aim.

The main factors that improve gut microbiota composition

The aim is to observe and compare the main factors that can improve gut microbiota composition. Materials and methods. The literature study research was performed in PubMed and Google Scholar electronic databases. We assessed more than 300 studies, data from 65 of which were included in this review. They are presented in three tables: nonpharmacological influence on gut microbiota composition, drugs impact on gut microbiota, and medicines prescribed for gut microbiota correction. Results. On the one hand, non-pharmacological methods of gut microbiota improvement are the safest and the most traditional: healthy diet and physical activity, good sleep, avoiding stress and bad habits, but they are the most difficult for patients’ fulfillment and doctors’ observation. All listed are the components of a healthy way of life and should be followed by everybody. The most prescribed drugs have a significant influence on gut microbiota composition, so physicians should consider their effects in prescriptions. They are antibiotics, steroids and non-steroids, proton pump inhibitors, laxatives, antidepressants, etc. On the other hand, despite the diversity of available medicines (prebiotics, probiotics, paraprobiotics, postbiotics, synbiotics, and antibiotics) that can be used for gut microbiota improvement, all of them are under investigation and need further evaluation. The trendiest medicines for today are paraprobiotics and postbiotics. Paraprobiotics are represented by heat / ultraviolet / sonication Lactobacillus spp., Bifidobacterium spp., and Saccharomyces strains. Postbiotics are performed by short-chain fatty acids, secreted biosurfactants, secreted proteins, organic acids, amino acids, bacteriocins, vitamins, and peptides. Most of the data on their pharmacodynamics is based on animal studies or experimental research, so they need further investigations. Fecal gut microbiota transplantation is also an up-to-date method for multiple disease correction but is approved only for the treatment of recurrent and refractory infections caused by Clostridium difficile. Conclusions. Gut microbiota composition improvement methods are an up-to-date topic for practical medicine because gut microbiota changes are closely linked with host health status. Gut microbiota violations lead to metabolic, cardiovascular, neurological, inflammatory disorders, etc. Nowadays the healthy way of life is the best gut microbiota composition improvement method, but prebiotics, probiotics, paraprobiotics, postbiotics, synbiotics, antibiotics supplementation, and fecal microbiota transplantation also take place and have their indisputable advantages in special cases. Unfortunately, most pharmacological methods of gut microbiota modulation have a weak evidence base. Therefore, this question needs further research in appropriate patient groups with long-term monitoring.

Causal Relationships of Ligamentous Injuries in the Knee on Corticospinal Tract Structure: A Mendelian Randomization Analysis.

The association between ligamentous knee injuries and corticospinal tract (CST) structure has attracted attention; however, any causal relationship remains uncertain. We performed Mendelian randomization (MR) analysis to identify the causal effects of ligamentous knee injuries on the CST. Ligamentous knee injuries impair CST microstructure (ie, by reducing fractional anisotropy [FA] and increasing mean diffusivity [MD]). MR analysis. Level 2. MR uses genetic variants as instrumental variables to infer causal relationships between exposures and outcomes. Summary data for ligamentous injuries in knee and CST structure were obtained from genome-wide association study datasets. Significant and independent (5 × 10-6; r2 < 0.001; 10,000 kb) single-nucleotide polymorphisms were extracted for MR analysis. Three methods for MR analysis were used (hypothesis-driven 1-tailed inverse variance weighted, MR-Egger, and weighted median), and sensitivity analyses were conducted to test reliability and stability. Results from 3 MR methods consistently demonstrated that ligamentous knee injuries increased MD of the right CST (β, 0.063; 90% CI, 0.003-0.123; P = 0.04), and weak statistical significance suggested increased MD of the left CST (β, 0.060; 90% CI, -0.002 to -0.121; P = 0.05). However, no significant causal relationships were observed in CST FA, and no significant pleiotropy or heterogeneity was observed. Sensitivity analysis utilizing 2-tailed tests had no significant associations between ligamentous knee injuries and changes in CST structure. There is statistically weak genetic evidence that corticospinal pathway abnormalities may evolve after ligamentous knee injuries, which manifests as abnormally organized neurites. Ligamentous knee injuries require attention not only to damage to the structure of the knee joint itself but also to the process of maladaptive neuroplasticity that leads to structural and functional changes of the CST; novel interventions that target the corticospinal pathway may provide subsequent treatment of ligamentous knee injuries.

Causality Analysis Between Exchange Rate, Current Balance Sheet, Inflation, and Gross Domestic Product in ASEAN-5 1980-2022

This research investigates the causality between exchange rate, current balance sheet, inflation, and gross domestic product in ASEAN 5 from 1980 to 2022. The method employs the Granger causality test. This research finds weak evidence of a J-curve effect on the current account balance in Indonesia because empirical results with several tests and models reject the J-curve hypothesis and do not find evidence of an influence of the rupiah exchange rate on Indonesia's current account balance in the long term so that it can the conclusion is drawn that: (1) There is no causal relationship between the current account balance and the exchange rate in Indonesia from 1996-2022; (2) Changes in exchange rates affect changes in the current account balance in the short and long term; (3) The mechanism for changes in the current account deficit does not affect changes in the exchange rate

Food for Thought: Understanding the Impact of Food Insecurity on Fertility Dynamics in the U.S.

This paper examines the relationship between food insecurity rates and fertility rates in the United States using panel data at the county level spanning from 2010 to 2017. Drawing upon health literature that highlights the disproportionate burden of food insecurity on women and its adverse effects on maternal and child health, I investigate the hypothesis that counties with lower rates of food insecurity exhibit lower fertility rates by employing an instrumental variable regression approach with two-way fixed effects. The two most notable findings are, first, that there is weak but suggestive evidence of a positive relationship between food insecurity and fertility at the national level and second, regional disparities can cause this relationship to turn negative. These findings underscore the significance of socioeconomic factors in shaping reproductive behaviors. Further research using alternative econometric techniques is warranted to investigate causal mechanisms in the observed relationship.

Depth Supervised Neural Surface Reconstruction from Airborne Imagery

Abstract. While originally developed for novel view synthesis, Neural Radiance Fields (NeRFs) have recently emerged as an alternative to multi-view stereo (MVS). Triggered by a manifold of research activities, promising results have been gained especially for textureless, transparent, and reflecting surfaces, while such scenarios remain challenging for traditional MVS-based approaches. However, most of these investigations focus on close-range scenarios, with studies for airborne scenarios still missing. For this task, NeRFs face potential difficulties at areas of low image redundancy and weak data evidence, as often found in street canyons, facades or building shadows. Furthermore, training such networks is computationally expensive. Thus, the aim of our work is twofold: First, we investigate the applicability of NeRFs for aerial image blocks representing different characteristics like nadir-only, oblique and high-resolution imagery. Second, during these investigations we demonstrate the benefit of integrating depth priors from tie-point measures, which are provided during presupposed Bundle Block Adjustment. Our work is based on the state-of-the-art framework VolSDF, which models 3D scenes by signed distance functions (SDFs), since this is more applicable for surface reconstruction compared to the standard volumetric representation in vanilla NeRFs. For evaluation, the NeRF-based reconstructions are compared to results of a publicly available benchmark dataset for airborne images.

The influence of ChatGPT on student engagement: A systematic review and future research agenda

ChatGPT, a state-of-the-art artificial intelligence (AI) chatbot, has gained considerable attention as a transformative yet controversial tool for enhancing teaching and learning experiences. Several reviews and numerous articles have been written about harnessing ChatGPT in education since its release on November 30, 2022. Besides summarising its strengths, weaknesses, opportunities, and threats (SWOT) as identified in previous systematic reviews of ChatGPT research, this systematic review aims to develop a new understanding of its influence on student engagement by synthesising the existing related research using a three-dimensional framework comprising behavioural, emotional, and cognitive aspects. We searched relevant databases and included 72 empirical studies published within one year of ChatGPT's initial release. The findings reveal robust but narrowly focused evidence related to behavioural engagement (i.e., work with ChatGPT) and disengagement (i.e., academic dishonesty). The evidence related to the emotional aspect is mixed, with instances of both engagement (e.g., satisfaction and interest/fun) and disengagement (e.g., disappointment and worry/anxiety). There is broad but weak evidence regarding cognitive engagement (e.g., increased understanding and positive self-perception) and disengagement (e.g., reduced critical thinking and overreliance). Our review uncovers several under-explored indicators of student engagement, pointing to the need for further research. Specifically, future studies could focus on students' study habits and attendance (behavioural engagement), social interaction (emotional engagement), and self-regulation and critical thinking (cognitive engagement) in ChatGPT-supported learning environments.

Which sectors go on when there is a sudden stop? An empirical analysis

This paper analyzes the dynamics of sectoral Real Gross Value Added (RGVA) around sudden stops in foreign capital inflows. We identify sudden stop episodes statistically from changes in gross capital inflows from the financial account. In the baseline specification, we estimate changes in the growth rate of sectoral RGVA during sudden stops and in the few quarters preceding and following them. We also look at whether real exchange rate movements and the depth of the RGVA decline on impact explain different sectoral dynamics afterwards. In an additional exercise, we analyze deviations from the sectors' long-run growth path. Our findings indicate that: (i) the construction sector experiences the largest drop in its growth rate during sudden stops; (ii) generally, tradable sectors, especially manufacturing, face larger damages during sudden stops than nontradable sectors, but they decelerate less in the medium run than some service sectors; (iii) the depth of the initial slowdown is related to a more favorable subsequent performance (a rebound effect), while we find only very weak evidence that real exchange rate depreciations facilitate adjustment. Overall, our results suggest a prolonged reallocation of economic activity away from service sectors, towards the production of goods. This is consistent with a traditional view of the role of tradable and nontradable sectors in a sudden stop episode.

Testing the Impact of Variations in Administration on the Kessler Psychological Distress Scale (K10).

Self-report measures are useful in psychological research and practice, but scores may be impacted by administration methods. This study investigated whether changing the recall period (from 30 to 7 days) and response option order (from ascending to descending) alters the score distribution of the Kessler Psychological Distress Scale (K10). Participants were presented with the K10 with either different recall periods or different response option orders. There was weak evidence of lower mean K10 scores when using a 7-day recall period than when using the 30-day recall period (B = 1.96, 95% CI [0.04-3.90]) but no evidence of a change in the estimated prevalence of very high psychological distress. Presenting the response options in ascending order did not affect mean scores, but there was weak evidence of reduced prevalence of very high distress relative to the descending order (incidence rate ratio [IRR] = 0.60, 95% CI [0.36-0.98]). These findings suggest that varying the administration method may result in minor differences in population estimates of very high psychological distress when using the K10.