The structure's ability to release energy through inelastic behaviour is reflected in the response reduction factor (R). It results from a combination of redundancy, ductility, and over strength. Thus, determining R with accurate values plays a critical function in the process of seismic design. This study aims to determine the response factor of structures of reinforced concrete (RC). With different structural irregularities, additionally, determine the impact of the interaction between soil and structure (SSI) using non-linear static pushover analysis was adopted in numerical simulation by using SAP2000. The selected irregularities included elevational and in-plan changes It was determined that, in comparison to regular buildings, buildings with irregular vertical geometries had poorer inelastic seismic capacities. Therefore, R is less than that which is stated in the ECP 2020, so it ought to be reduced by 15–40% before the design stage. The outcomes demonstrated that It isn't concluded that irregularity has a considerable effect on weak soil (C). The reduction in R, considering (SSI), reached 20.3% and 13.1% for fixed and isolated supports, respectively, in case of loose soil. Moreover, it became obvious that for the same structure the stiffer the base soil the greater the R's value.
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