Weak Negative Correlation Research Articles

Efficacy and fibrinogen correlations of defibrinogen therapy in idiopathic sudden sensorineural hearing loss

This study aimed to assess the efficacy of Defibrinogen (DF) therapy in addressing total deafness of idiopathic sudden sensorineural hearing loss (TD-ISSNHL) and investigate the relationship between fibrinogen levels and auditory outcomes. A total of 342 cases of TD-ISSNHL were retrospectively analyzed, with patients divided into two main groups: an experimental group receiving batroxobin in conjunction with Ginaton and glucocorticoids, and a control group receiving Ginaton and glucocorticoids only. Auditory outcomes on the 10th day and the 14th day were analyzed and compared across these groups. Subsequently, the correlation between plasma fibrinogen and prognosis were analyzed within these groups. By the 10th day, the overall efficacy rates in the experimental groups were significantly higher than that in the control group (P = 0.039). Patients extending DF therapy to the 14th day showed a substantial improvement in the overall efficacy rate, from 50.98 to 82.35%. Additionally, significant differences in fibrinogen levels were observed on day 1, day 3, and day 5 ± 1 between the recovery and non-recovery groups (P = 0.013, P = 0.024, P = 0.005). Spearman’s rank correlation analysis indicated weak negative correlations between fibrinogen levels on day 1 and day 3 and hearing improvement, while the level on day 5±1 had a moderate negative correlation. Throughout the follow-up period, no major complications were observed. The study findings suggest that batroxobin therapy not only improves hearing recovery but also maintains plasma fibrinogen at a low and safe level. In addition, sustained low fibrinogen level throughout treatment serves as a predictor for better prognosis in TD-ISSNHL.

The associations of mindful and intuitive eating with BMI, depression, anxiety and stress across generations: a cross-sectional study.

The study aimed to evaluate the differences between generations and relationship between mindful and intuitive eating with body mass index (BMI), depression, stress, and anxiety. This cross-sectional study was conducted on 547 adults. Online questionnaire including Intuitive Eating Scale-2nd edition (IES-2), Mindful Eating Questionnaire (MEQ), and Depression, Anxiety, Stress Scale was performed. Gen Z scored highest for "unconditional permission to eat", and lowest for "interference" (p < 0.001). Baby Boomers demonstrated the lowest "conscious nutrition" scores compared to others (p: 0.002). Weak negative correlations were observed between IES-2 scores and BMI (r: -0.165, p < 0.001), depression (r: -0.194, p < 0.001), anxiety (r: -0.191, p < 0.001), and stress (r: -0.100, p: 0.020). MEQ scores were negatively correlated with BMI, depression, anxiety, and stress (r: -0.159, r: -0.364, r: -0.372, r: -0.360, p < 0.001). "Eating for physical rather than emotional reasons" showed negative correlation with depression, anxiety, and stress scores (r: -0.259, r: -0.249, r: -0.168, p < 0.001).

Leukocyte profiles in bull semen and their relationship with sperm quality parameters

The role of leukocytes in semen remains controversial, with both beneficial effects, such as the removal of microorganisms and abnormal sperm, and harmful effects, including reactive oxygen species (ROS) production and reduced fertility potential. Research on this topic in farm animals is limited. This study investigated correlations between differential leukocyte counts in bull semen and sperm parameters, both fresh and post-thaw. A total of 44 ejaculates from 36 adult bulls were collected using the artificial vagina method. Semen cytology was performed with Diff-Quick staining, and leukocytes were quantified under an optical microscope. Sperm parameters analyzed included ejaculate volume, motility (fresh and post-thaw), concentration, and morphology (major, minor, and total defects). Lymphocytes predominated (82%), followed by macrophages (13%), neutrophils (4%), and eosinophils (1%). Neutrophils showed weak negative correlations with major defects (r = -0.36, P = 0.027) and total defects (r = -0.328, P = 0.047), as well as a moderate negative correlation with post-thaw motility (r = -0.515, P = 0.0012) in Spearman’s correlation analysis. In contrast, lymphocytes, macrophages, and eosinophils showed no significant correlations with sperm parameters. These findings suggest that among leukocyte populations, only neutrophils negatively impact sperm morphology in fresh semen and motility in thawed semen.

Association Between Colleague Violence and the Professional Image of Nursing and Career Decisions Among Nursing Students: A Cross-Sectional Study.

To examine how colleague violence affects professional image and career decisions among nursing students. This cross-sectional study was conducted from February 1 to March 1, 2023, at two public universities in Turkey. All nursing students who met the inclusion criteria and voluntarily agreed to participate were included without any special sample calculation, and a final sample of 357 students was obtained. Data were collected between February 1 and March 1, 2023. Data were collected using a survey form that included questions on sociodemographic characteristics, as well as three scales: the Exposure to Colleague Violence Scale (ECVS) scale, the Image of Nursing Profession Scale (INPS) scale, and the Career Decision Scale (CDS). Data analysis included descriptive statistics, t-tests, ANOVA, Pearson correlation, and regression analyses. The mean ECVS score was 45.43 (20.80), the mean INPS score was 147.15 (13.51), and the mean CDS score was 79.67 (17.34). A weak negative correlation was found between colleague violence and nursing image, a weak positive correlation between colleague violence and career decision, and a moderate negative correlation between nursing image and career decision. This study highlights the negative impact of exposure to colleague violence on nursing students, affecting both their professional image and career decision-making. Greater exposure to colleague violence correlates with more negative perceptions of the nursing profession and increased uncertainty in career choices. Implementing targeted interventions to reduce and prevent colleague violence, especially in clinical practice settings, is essential for promoting a positive professional image and supporting informed career decisions among nursing students. Addressing and reducing colleague violence among nursing students can enhance their professional image and decision-making regarding their careers, which, in turn, may lead to improved patient care and more significant long-term commitment to the nursing profession. This study adhered to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines for cross-sectional studies. There was no patient or public involvement in this study.

The effect of cachexia and anti-cancer therapies on GDF-15 levels in patients with pancreatic adenocarcinoma.

778 Background: Growth differentiation factor 15 (GDF15) is a novel biomarker in the setting of pancreatic adenocarcinoma (PDAC). Preliminary studies have found that downstream effects of GDF-15 promote the progression of pancreatic cancer. PDAC has a high prevalence of cachexia which is commonly treated with enzyme supplementation and nutritional support. Platinum-based therapies often used to treat PDAC increase the likelihood of patients experiencing cachexia. The purpose of this study was to observe the GDF-15 levels in respect to weight change of PDAC patients being treated with cachexia and anti-cancer therapies. Methods: Serum and Plasma samples were collected from locally advanced and advanced PDAC patients on 5 IRB approved studies from 2014-2024. Samples were analyzed using the R-PLEX Human GDF-15 Antibody Set. The study objective was compared using two-sample paired t-tests and Pearson correlation matrices. Elevated GDF-15 was determined as &gt;1500 pg/mL. Results: Samples from 73 patients were utilized for this study (63% female; median age: 69; BMI: 23.31±4.96 kg/m 2 ). At baseline 71.8% (46/64) had elevated GDF-15, at Cycle 3 76% (25/33), and at Cycle 5 86% (25/29). In the total sample set, there was a slight negative correlation in the change of weight (-1.75 kg, p = 0.013) and GDF-15 (577.5 pg/mL, p = 0.278) from C1 to C3 (r = -0.185, p = 0.366). There was a slight negative correlation (r = -0.44, p = 0.076) in the difference of weight and GDF-15 from C1 to C3 in patients receiving chemotherapy. A strong negative correlation was observed in the change of GDF15 and weight from C1D1 to C1D8 in patients treated with platinum-based therapy (r = -0.530, p = 0.212) and a weak negative correlation (r = -0.421, p = 0.065) for patients with non-platinum-based therapy. There was a strong positive association (r = 0.993, p &lt; 0.01) between the change in weight and GDF-15 from C1 to C5 in patients not receiving chemotherapy. There was no significant decrease in GDF-15 levels across the patients at all time points. Conclusions: Despite cachexia and anti-cancer treatment, the GDF-15 levels of PDAC patients continue to remain elevated in consecutive blood draws. Further research in GDF-15 kinetics is warranted. Clinical trial information: NCT02400398 , NCT03207724 , NCT04098237 , NCT05336266 , NCT04634539 . Weight and GDF-15 levels across different chemotherapy regimens. Baseline Cycle 1 Cycle 3 Cycle 5 BMI (kg/m2) Weight (kg) GDF15 (pg/mL) Weight (kg) GDF15 (pg/mL) Weight (kg) GDF15 (pg/mL) Chemotherapy 23.21 63.83 3243.25 63.44 3498.76 60.14 3201.33 No Chemotherapy 23.77 65.85 3113.73 62.32 2949.56 71.05 2944.54 Platinum Based 20.88 59.89 6527.78 51.7 3600.87 58.1 5152.50 Non-platinum-based chemotherapy 23.86 64.89 2442.14 64.67 3487.41 60.39 2957.43

Do menstrual symptoms affect motor imagery skills in young women?

To examine the relationship between menstrual symptoms and motor imagery skills in young women. A total of 117 women between the ages of 18-40 were included in the study. Visual Analog Scale (VAS) for the menstrual pain intensity, the Menstrual Symptom Questionnaire (MSQ) for the menstrual-related symptoms, and the Kinesthetic and Visual Imagery Questionnaire-20 (KVIQ-20) for the motor imagery were used. All measurements were conducted on the first or second day of the menstruation, depending on when the subject declared subjectively experiencing most symptoms. The relationship between menstruation symptoms and visual imagery (VI) and kinesthetic imagery (KI) skills was examined. A weak negative correlation was found between MSQ_negative effects/somatic complaints and KVIQ-20_KI (p = .040, r = -.199). The relationship between menstrual pain intensity and KVIQ-20 items was examined. The strongest relationship was found between VAS and KVIQ-20_knee_VI and KVIQ-20_hip_VI (p = 003, r = -.288; p = 005, r = -.270; p = 004, respectively). A weak negative correlation was also found between VAS and KVIQ-20_VI_total and KVIQ-20_KI_total (p = 0.004, r = -.275; p = 0.19, r = -.227, respectively). This is the first study to examine menstrual symptoms in women in detail and reveal their relationship with motor imagery skills. Menstrual symptoms, especially negative effects/somatic complaints seen during menstruation, negatively affect kinesthetic imagery ability. In addition; chronic menstrual pain has a negative effect on both kinesthetic and visual imagery abilities. Considering the impairments in motor imagery skills due to negative effects/somatic complaints during menstruation and chronic menstrual pain, adding motor imagery training to treatment programs aimed at improving women's health may have positive effects.

Radiation dose proportions of localizer radiograph and bolus tracking in low-dose pediatric cardiothoracic computed tomography.

Optimization of localizer radiograph and bolus tracking doses is necessary, as their dose proportion may increase with a decreasing diagnostic scan dose in pediatric cardiothoracic computed tomography (CT). To evaluate the radiation dose proportions of the localizer radiograph and bolus tracking in low-dose pediatric cardiothoracic CT. For low-dose pediatric cardiothoracic CT, a posteroanterior localizer radiograph was acquired with 80 kV, and 35 mA or 20 mA in 852 infants (age<1 year). Propensity score matching was employed in comparing the 35 mA and 20 mA groups on dose proportion, over z-axis proportion, visibility of anatomic landmarks, and image noise. The over z-axis coverage proportion was correlated with the dose proportion of the localizer radiograph in both groups. Additionally, bolus tracking was performed in 1,015 children (≤2 years). The effects of the number of monitoring scan, dose-length product of the diagnostic scan, age, and water-equivalent area of the scanned patient body on the radiation dose proportion of bolus tracking were evaluated. The dose proportion of the localizer radiograph was significantly lower in the 20 mA group (2.5%, n= 94) than in the 35 mA group (6.5%, n= 94) (P< 0.001). While image noise was higher in the 20 mA group (2.1 Hounsfield units versus 1.0 Hounsfield units of the 35 mA-group, P< 0.001), all the anatomic landmarks remained visible in all cases. The over z-axis coverage proportion demonstrated high correlations with the dose proportion for both groups (R= 0.736, P< 0.001 for the 35 mA group and R= 0.660, P< 0.001 for the 20 mA group). The bolus tracking dose-length product proportion demonstrated the strongest positive correlation with the number of monitoring scans (R= 0.93, P< 0.001), while age, diagnostic scan dose-length product, and water-equivalent area showed weak negative correlations (R-values = -0.46~-0.50, P-values < 0.001). In low-dose pediatric cardiothoracic CT, the dose proportion of the localizer radiograph can be substantially reduced with a low tube current setting while maintaining image quality. Additionally, minimization of the over z-axis coverage proportion merits attention. The number of monitoring scans is the most significant factor for increasing the radiation dose proportion of bolus tracking, especially in young ages.

Cyber Bullying, Psychological Distress and Quality of Life among Employees: A Correlational Study

This research was conducted to investigate the connection between cyber-bullying, psychological distress, and quality of life among employees. For this purpose, a cross-sectional correlational research design was used and a sample of 150 participants was selected through convenient sampling technique from various organizations in Faisalabad city. A demographic sheet, Cyber bully/Victim Scale, Kessler Psychological Distress Scale (K10), and Quality of Life Scale (QOLS) were used to collect the data. The data was analyzed using the Statistical Package for Social Science (SPSS). The results revealed a significant positive correlation between cyber-bullying and psychological distress and a weak negative correlation with quality of life. Further, the t-test analysis reported similar levels of cyber-bullying in both genders but female employees’ scores were higher on psychological distress and quality of life as compared to male employees. The findings emphasize the need for organizations to implement anti-cyber-bullying policies, accessible support services, and gender-sensitive mental health resources to foster a safer and healthier workplace culture. This study contributes valuable insights into the growing concern of workplace mental health in digitally connected environments.

Left atrial appendage velocity, association with inflammatory indices in non-valvular atrial fibrillation patients.

Decreased left atrial appendage emptying velocity (LAAV) is a marker for thrombus formation. This study evaluates the association between LAAV and inflammatory indices in non-valvular atrial fibrillation (AF) patients. The study population was 1428 patients with AF, 875 of whom enrolled. Based on the LAAV, patients were divided into three groups of 262 patients with a velocity of <25 cm/s, 360 patients with a velocity of 25 to 55 cm/s, and 253 patients with a velocity of >55 cm/s to assess and compare in terms of inflammatory indices, including the platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, systemic immune inflammation index, neutrophil - to - platelet ratio and white blood cell-to-platelet ratio (WPR). There was no statistical difference in the level of inflammatory indices between the three groups, and none of them were related to LAAV (p > .05) except WPR with a weak negative correlation (p = 0.01, r = -0.10). Patients with lower LAAV were found to have a higher age (p = 0.001), decreased left ventricular ejection fraction (p = 0.001) and greater left atrial volume index (p = 0.001). This study did not show any association between inflammatory indices and LAAV in non-valvular AF patients except for the WPR.

Relationship between Topographic Wetness Index and Soil Physical Properties in Cikapundung Sub-watershed Using Geographic Information Systems

Purpose: This study aimed to analyze the relationship between Topographic Wetness Index (TWI) and soil physical properties (permeability, porosity, bulk density, and soil moisture content) and their spatial distribution in the Cikapundung Sub-watershed. Methods: A survey method was conducted through descriptive, correlation, and interpolation approaches. Thirty soil samples were collected based on a two-way stratification method using TWI and slope gradient. TWI was derived from Digital Elevation Model (DEM) data using GIS. Soil physical properties were analyzed in laboratory and their spatial distribution was mapped using interpolation techniques. Results: TWI showed varying degrees of correlation with soil physical properties: significant positive correlation with soil permeability (r = 0.37), weak negative correlation with soil moisture content (r = -0.30), and very weak correlations with bulk density and soil porosity (r = -0.03 and r = 0.03). Spatial analysis revealed heterogeneous distribution patterns of soil physical properties across the sub-watershed. Conclusion: TWI can only be effectively used as a single predictor for soil permeability, but not for bulk density, porosity, and soil moisture content in the Cikapundung Sub-watershed. This suggests the need for additional environmental parameters when predicting these soil physical properties.

Dynamics of Annual Сone Crops of Siberian Fir (Abies sibirica Ledeb.) in Conifer Forests of Pre-Ural Region (Russia) Based on 47 Years of Observations

Because seed reproduction is the sole means of reproduction available for coniferous tree species, it plays a crucial role in determining the species’ ecological adaptability and the competitiveness of species under specific biocoenosis conditions. Therefore, the primary goal of studying the periodicity and cyclical production of cones (seeds) is to forecast the peaks and recessions of natural renewal in various forest ecosystems. The crop dynamics of Siberian fir (Abies sibirica Ledeb.) cones in three mature natural conifer forests in the broad-leaf coniferous forest subzone of the pre-Ural region (Russia) was analysed based on long-term observations spanning 47 years. The conifer forests investigated had a considerable deficit of cones (seeds) for natural renewal under the forest canopy. High cone crops occur every 10 years or twice a decade under most favourable conditions. However, cone production has no distinct periodicity, and it is impossible to forecast a high crop of cones based only on long-term data. The levels of fir crop cones were clearly correlated with climate factors. Late winter climate in previous (weak and moderate positive correlation) and current years (weak and moderate negative correlation) affected the fir cone crop. High and even average fir cone crops occur spontaneously with no discernible pattern. In coniferous forests, cone crops are highest on slopes with high insolation levels and on sustainably wet soils.

Peer Pressure and Academic performances of Students Enrolled in Public Sector Universities of Azad Jammu and Kashmir

The present quantitative study was conducted to determine the level of peer pressure, its relationship, and its impact on the academic achievements of students enrolled in the universities of Azad Jammu and Kashmir/AJK. A random sample of 400 out of 34000 students determined by sample size formula (Solvin, 1960) participated in the study. Peer Pressure Questionnaire (Saini, 2016) was used to measure the peer pressure among participants. CGPA was collected as an indicator of academic performances. The results of the study show that the majority (75.5%) of students experiences moderate level of peer pressure. A weak but significant negative correlation (r = -0.218, p = 0.035) was observed indicating that as peer pressure increases the academic performance slightly decreases. Regression analysis revealed that peer pressure has small but negative (β = -0.163, p = 0.001) impact on the academic performances, with each unit increase in peer pressure leading to 0.012 units decrease in academic performance. Results of the study align with past researchers and demonstrate why students should be able to fend off negative peer pressure by forming support networks with mentors and counselling professionals. The study recommends that pressure variations between cultures and genders, may be explored and the mechanisms behind positive peer interactions may also be identified.

Correlation analysis between epicardial adipose tissue and acute coronary syndrome

To investigate the correlation between the density and volume of epicardial adipose tissue(EAT)and acute coronary syndrome (ACS). This study included 355 subjects (mean age: 60.65 ± 9.67 years; 54.65% male), comprising 175 patients with ACS and 180 without ACS. Propensity score matching was applied to balance the variables between the two groups, resulting in 96 successfully matched pairs. Clinical data, epicardial adipose tissue volume (EATV), and epicardial adipose tissue density (EATD) were compared. Independent factors influencing ACS were identified using logistic regression analysis, and the predictive ability of each variable was evaluated using receiver operating characteristic (ROC) curves. Systolic blood pressure, EATV, EATD, fasting blood glucose, triglycerides, and high-sensitivity C-reactive protein were significantly elevated in the ACS group compared with the non-ACS group (all p < 0.05). Spearman correlation analysis revealed a moderate positive correlation between EATV and BMI (r = 0.444, p < 0.001), while EATD showed a weak negative correlation with age (r = -0.177, p = 0.014) and a weak positive correlation with EATV (r = 0.239, p = 0.001). Univariable regression analysis demonstrated that both EATV (OR: 2.018, 95% CI: 1.334–3.052) and EATD (OR: 5.341, 95% CI: 3.293–8.663) were associated with ACS. After adjusting for other risk factors, logistic regression model confirmed that EATV (adjusted OR: 1.892, 95%CI: 1.211–2.955) and EATD (adjusted OR: 6.942, 95%CI: 3.875–12.437) were independent predictors of ACS (both p < 0.001), with EATD showing the highest predictive value (AUC = 0.859). This study identifies a close relationship between EAT and ACS, highlighting EATD and EATV as independent influencing factors for ACS. Among them, EATD demonstrated a stronger predictive value for ACS than both traditional risk factors and EATV.

P1214 Too Many Couch Potatoes Among Middle-Aged Inflammatory Bowel Disease Patients! Findings From the “BE-FIT-IBD-2” Study on Patient-Reported Physical Activity Levels Examining Their Interactions with IBD-Related Factors and Barriers/Facilitators

Abstract Background Regular physical activity (PA) is desirable, regardless of age, even in patients with chronic conditions such as those with inflammatory bowel disease (IBD), although this issue has been addressed heterogeneously in this setting, with the absence of clear recommendations to follow. This study aimed to assess PA levels in IBD patients, stratifying them into age groups (with a threshold of 50 years), highlighting differences, including barriers/facilitators to PA. Methods The Italian-validated International PA questionnaire (IPAQ) assessed PA levels regarding resting metabolic rate (Met) in minutes/week. Patients were classified as inactive (&amp;lt; 700 Met min/wk), sufficiently active (700-2500 Met min/wk), or active/HEPA (&amp;gt; 2500 Met min/wk) based on the total score computed from the different types of PA intensities. IBD disease activity was evaluated using patient-reported outcomes 2 (PRO-2). Additionally, a questionnaire was administered to identify factors promoting/hindering regular PA in this setting. Results Among the 237 enrolled patients [median age of 43 (30 - 56) years; 149 (62.9%) below the age of 50 and 88 (37.1%) aged at least 50 years], PA rates were found to differ significantly in terms of patients being sufficiently active (55% vs. 39.8%), inactive (39.6% vs. 59.1%), and engaging in health-enhancing PA (5.4% vs. 1.1%) between patients under and at least 50 years old, respectively (P=0.0002). Overall PA levels followed this trend, being higher in younger patients [892 (446.5 - 1439) vs. 545.25 (257 - 1210.47) Met min/wk, P=0.007]. Being at least 50 predicted physical inactivity (β=1.194, OR: 3.302, 95% CI 1.224 - 8.905, P=0.018). A weak negative correlation was found between age and PA total score for intense activities (□□□□= -0.127, p = 0.049). Disease activity did not impact PA levels (p &amp;gt; 0.05). Patients aged at least 50 years perceived IBD as more of a barrier to PA compared to younger individuals (P=0.04). Bowel urgency is a significant barrier, especially in older patients. The significance patients placed on discussing PA with their IBDologist, on a 10-point Likert scale, was not influenced by age group [6 (4 - 8) vs. 5 (3 - 8), P=0.119]. Figures A-P summarize these results. Conclusion Age is an unmodifiable factor that impacts and influences PA levels. Strategies to recover exercise levels in older IBD patients should be encouraged. References Gravina AG, Pellegrino R, Durante T, et al. Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity: The "BE-FIT-IBD" study. World J Gastroenterol. 2023;29(41):5668-5682. doi:10.3748/wjg.v29.i41.56682. Gravina AG, Pellegrino R, Palladino G, et al. Profiling the patient with inflammatory bowel disease in the relationship between physical activity and partner/social network status: A post hoc patient-tailored analysis of the "BE-FIT-IBD" study. Gastroenterol Hepatol. Published online May 8, 2024:S0210-5705(24)00161-4. doi:10.1016/j.gastrohep.2024.5022033. Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381-1395. doi:10.1249/01.MSS.0000078924.61453.FB

Influence of Fluid Intake on Biophysical Properties of the Stratum Corneum in Elderly Individuals: A Cross-Sectional Study

Objective: Water plays a crucial role in human health. Inadequate water intake can lead to various health issues, particularly dehydration in the elderly. The skin, constituting approximately 30.0% of the body’s surface area, is essential in preventing dehydration, and water contributes significantly to its resilience, elasticity, and durability. This study aimed to establish a definitive relationship between fluid intake and various biophysical properties of the stratum corneum in elderly Individuals. Methods: This cross-sectional study was conducted on individuals aged 65–80 years at the Elderly Social Institution Tresna Budi Mulia 3 in Jakarta, between April and August 2023. Correlation analysis (Pearson and Spearman tests) was used to evaluate relationships between variables, and non-parametric tests (Mann–Whitney and Friedman tests) were used to assess differences. Fluid intake was assessed over 7 days. On the 8th day, the hydration status of the stratum corneum was evaluated by examining their urine concentration, skin dryness through subjective symptoms, skin water loss based on the rate of water evaporation from the skin, and skin capacitance (SCap) according to the skin’s ability to retain moisture. Results: The study involved 67 subjects with a median age of 70 years. Multiple regression analysis showed that fluid intake significantly predicted the specified symptom sum score (SRRC) (coefficient = −9.15 × 10⁻5, P = 0.001), urine specific gravity (coefficient = −0.01, P = 0.016), and SCap (coefficient = 0.005, P = 0.022). Additionally, a statistically significant weak negative correlation was found between fluid intake and hydration status (P &lt; 0.0001) and between fluid intake and SRRC (P &lt; 0.0001). However, no significant correlation was observed between fluid intake and transepidermal water loss (P = 0.613) or SCap (P = 0.060). Conclusion: This study highlights the potential role of fluid intake in influencing hydration status among elderly individuals. While fluid intake is significantly associated with certain biophysical properties of the skin, it does not show a consistent correlation with all measures of skin hydration and moisture retention.

P0555 Quantitative Assessment of Colon Motility in Ulcerative Colitis using Magnetic Resonance Enterography: Correlation with Endoscopic Disease Activity

Abstract Background Changes in small bowel motility have been quantified by magnetic resonance enterography (MRE) in Crohn’s disease to assess disease activity, but there is no data about colon motility changes in ulcerative colitis (UC). The aim of this study was to examine the correlation between colon motility (bowel wall motion) and endoscopic and laboratory features of activity in patients with UC. Methods This prospective study included 33 adults with known UC (mean age 38 [SD: 12.9] years, 51% female) and 30 controls (mean age 46 [SD: 15.2] years, 73% female). Two board-certified radiologists, blinded to clinical and endoscopic information, assessed motility scores for each colonic segment from dynamic cine MRE sequences using FDA-approved software with higher GIQuant scores indicating greater motility. Mayo endoscopic scores (MES) were determined by two experienced gastroenterologists in a consensus for each segment. Colonoscopy and laboratory tests were performed within 14 days of MREs. We used a mixed-effects linear model to evaluate the correlation between MES and motility scores across the five segments per patient. Results UC group consisted of 12 (36%) and 21 (64%) patients with left-sided colitis and pancolitis, respectively. The median value of GIQuant score for all colonic segments was significantly lower in UC patients (1184, IQR 693 to 1675) than controls (1245, IQR 851 to 1693) (p= 0.006). There was a decreasing trend of motility from ascending colon to rectum in controls with the similar pattern in UC patients except for lower motility of sigmoid than rectum. Per segment analysis of UC cases revealed a weak negative correlation between GIQuant and MES only in sigmoid (r= -0.2, p= 0.01). The mixed-effects model in per patient analysis identified a significant negative association between MES and GIQuant, indicating that each one-score increase in MES corresponds to a 144.3-point reduction in GIQuant between the less and more-involved colonic segment (β = -144.30, SE = 33.19, p &amp;lt; 0.001, 95% CI: -209.34 to -79.25). No significant correlation was found between the median GIQaunt score of all involved colonic segments and fecal calprotectin or serum CRP levels. Conclusion Higher endoscopic UC activity in each colonic segment is associated with lower motility compared to the less involved segments in each patient. Given the significant between-patient variability, colon motility should be assessed individually. MRE-based colon motility scores may provide an objective, transmural and physiological impression to complement endoscopy which may aid personalized assessment of UC activity.

P0679 Therapeutic Drug Monitoring of the Infliximab (anti-TNF) Level with Bedside Kit in Inflammatory Bowel Disease

Abstract Background Approximately half (10-40%) of the Inflammatory Bowel Disease (IBD) patients using Infliximab (IFX) develop secondary loss of response due to drug levels falling below the therapeutic range. This study aims to identify drug levels, influencing factors and parameters that may be useful in predicting target drug levels. Methods The pre-infusion drug levels and associated laboratory parameters were evaluated in IBD patients on maintenance dose of IFX (5-15 mg/kg every 4-8 weeks) between Nov2021 - Oct2024. Drug levels were measured using a bedside kit capable of quantitatively detecting values between 0.4-20 µg/ml. Results In total, 931 single pre-infusion measurements from 415 different patients, and dual measurements at weeks 4 and 8 from 116 patients were separately evaluated. 82% of the patients in the single measurement group, and 84% in the double measurement group had Crohn’s disease(CD), rest having Ulcerative Colitis. The most used doses in the single measurement group were 5 mg/8 weeks and 10 mg/4 weeks (Table 1). In the single measurement group, median albumin was 4.4 (IQR: 0.5), and median CRP was 3.1 (IQR: 6.4). Drug levels were below 5 µg/ml in 33% of measurements. CRP showed a significant difference according to drug level groups (Table 2), while no such difference was observed for albumin. In the measurable IFX range (0.4-20 µg/ml), correlation analysis revealed a weak negative correlation between CRP and drug levels (r: -0.09, p: 0.03). Regression analysis showed that lower CRP, higher drug dose, and CD diagnosis were independently associated with achieving &amp;gt;5 µg/ml drug levels. In the dual measurement group: The median CRP levels of patients at weeks 4 and 8 were 2.1 (5.1) and 2.6 (6.2), respectively (p&amp;gt;0.05). Among patients with IFX levels &amp;gt;20 µg/ml at week 4, 79% maintained levels &amp;gt;5 µg/ml at week 8, while this rate dropped to 71% for those with levels &amp;gt;10 µg/ml. Only 67% of patients with levels &amp;gt;5 µg/ml at week 4 maintained a level of &amp;gt;5 µg/ml at week 8 (all p-values &amp;lt;0.001). Conclusion As drug levels increase, significant reductions in CRP levels are observed. Therefore, low CRP levels may predict the likelihood of achieving the therapeutic range. Dose adjustment should be considered in cases with high CRP levels. Achieving a high drug level (&amp;gt;20 µg/ml) at 4th week is an important indicator of achieving at least an acceptable drug level (&amp;gt;5 µg/ml) at the end of treatment. (8th week).

Surgical fear and sleep quality effect the postoperative quality of recovery in patients undergoing brain tumor surgery: cross sectional study

BackgroundPatients with a brain tumor experience high levels of anxiety because of the fear of remaining functional and neuropsychological sequelae. This situation affects the postoperative quality of recovery. This study was conducted to determine the effect of surgical fear and sleep quality on the postoperative quality of recovery and pain.MethodThis cross-sectional study was completed with 101 patients who met the inclusion criteria and underwent craniotomy under general anesthesia for a brain tumor between October 2020 and August 2021 in a university hospital. The data were collected using the Patient Information Form, Surgical Fear Scale, Richard Champell Sleep Scale, Quality of Recovery Questionnaire, and Patient Follow-up Form. Hierarchical regression analysis was used to reveal the determinants of postoperative quality of recovery.ResultsThe mean fear of surgery score of women was higher than men, and sleep quality and postoperative quality of recovery were lower than men (p = 0.045). A moderate negative correlation between fear of surgery and sleep quality was found (r = -0.377; p = 0.000). There was a weak negative correlation between fear of surgery and postoperative recovery quality (r = -0.252; p = 0.011), and a weak positive correlation between preoperative sleep quality and recovery quality (r = 0.297; p = 0.003). The variables of fear, sleep, duration of hospital stay, pain, and age were found to be statistically the best predictors of postoperative quality of recovery (R2 = 0.295; p = 0.000).ConclusionAs a result, surgical fear, sleep deprivation, and pain during the perioperative period negatively impact recovery quality and prolong the healing process. Psychological preparation by starting from the pre-operative period, providing sleep and rest, evaluation, and management of postoperative pain would contribute to the early recovery and discharge of patients.

Neovascular age-related macular degeneration on three nationwide survey and register data in Finland during 2000-2017.

To evaluate time trends in the incidence and prevalence of neovascular age-related macular degeneration (nAMD) and its treatments, associated factors, and effects on vision in Finland during 2000-2017. We used three nationwide health examination surveys representing the Finnish population aged 30 years or older. All three surveys were linked to the national care register covering nAMD diagnoses and intravitreal injections between 2000 and 2017. All three surveys included a health examination in which distance and near visual acuity (VA) were measured, as well as self-reported and register-based information on socio-demographic status and lifestyle, health care use, co-morbidities, and quality of life. The data included two cross-sectional time points in 2011 and 2017 and two 11 year longitudinal follow-ups during 2000-2011 and 2006-2017. The incidence and prevalence of nAMD were two times higher in women than in men. The annual prevalence of nAMD increased from 0.51% to 0.70% and from 0.22% to 0.46% in treated nAMD between 2011 and 2017. Treated nAMD patients had an average of 4 intravitreal injections per treatment year. nAMD patients showed significantly poorer distance and near VA than persons without any AMD in 2011 and 2017 (p < 0.001). However, near VA was significantly better in 2017 than in 2011 among nAMD patients (p = 0.036). The duration of nAMD showed weak negative correlation with distance and near VA. After adjusting for age and sex, nAMD patients showed significantly higher univariable odds ratios for lower distance VA, low consumption of vegetables, living in central Finland, a higher number of hospitalisations per year, and older age compared with persons without any AMD. Since nAMD is an increasing burden for public health with gender discrepancy and a detrimental impact on vision, we should better find patients who have a high risk of developing nAMD and try to optimise their preventive intervention. Once nAMD is developed, we should understand treatment and follow-up demands at the personalised level. The nationwide register data help us in those challenges.

Investigation of the relationship between functional tests and low back pain functional scale in patients with chronic low back pain

Aims: The aim of this study is to investigate the relationship between functional scales used to determine the functional level in patients with chronic low back pain and functional tests. Methods: The study included 39 patients with chronic low back pain. We used the Low Back Pain Functional Scale (LBPFS) as a scale to determine the functional status of patients and the 5-Repetition Sit-to-Stand Test (5-RSTST) and Timed Up and Go Test (TUGT) as functional tests. Pearson correlation test was used for data analysis. Results: There was a moderate negative correlation between the total score of LBPFS and 5-RSTST (r: -0.427, p &lt; 0.007), and a weak negative correlation between LBPFS and TUGT (r: 0.246, p&lt; 0.05). Conclusion: LBPFS, which is used to determine the functional level in patients with chronic low back pain, has a moderate negative relationship with 5-RSTST and a weak negative relationship with TUGT. This result shows that LBPFS is insufficient to fully determine the function in patients with chronic low back pain and does not address all the parameters necessary to determine the function. The parts of the structure of LBPFS that are insufficient to determine the function can be reviewed to ensure that it determines the function more consistently. In this way, it is possible to determine the functional level more objectively with only one scale in patients with chronic low back pain who cannot perform functional tests or do not need to perform them.