Abstract We present a joint X-ray, optical, and weak-lensing analysis for X-ray luminous galaxy clusters selected from the MCXC (Meta-Catalog of X-Ray Detected Clusters of Galaxies) cluster catalog in the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) survey field with S16A data. As a pilot study for a series of papers, we measure hydrostatic equilibrium (HE) masses using XMM-Newton data for four clusters in the current coverage area out of a sample of 22 MCXC clusters. We additionally analyze a non-MCXC cluster associated with one MCXC cluster. We show that HE masses for the MCXC clusters are correlated with cluster richness from the CAMIRA catalog, while that for the non-MCXC cluster deviates from the scaling relation. The mass normalization of the relationship between cluster richness and HE mass is compatible with one inferred by matching CAMIRA cluster abundance with a theoretical halo mass function. The mean gas mass fraction based on HE masses for the MCXC clusters is 〈fgas〉 = 0.125 ± 0.012 at spherical overdensity Δ = 500, which is ∼80%–90% of the cosmic mean baryon fraction, Ωb/Ωm, measured by cosmic microwave background experiments. We find that the mean baryon fraction estimated from X-ray and HSC-SSP optical data is comparable to Ωb/Ωm. A weak-lensing shear catalog of background galaxies, combined with photometric redshifts, is currently available only for three clusters in our sample. Hydrostatic equilibrium masses roughly agree with weak-lensing masses, albeit with large uncertainty. This study demonstrates that further multiwavelength study for a large sample of clusters using X-ray, HSC-SSP optical, and weak-lensing data will enable us to understand cluster physics and utilize cluster-based cosmology.