Weak Effect Research Articles

Biometric analysis of the cranial features of common voles

Although cranial bones reliably identify the features of mammals, these traits can be affected by sex, population size and seasonality. This paper biometrically analyses the cranial features of the common vole. The research sample consisted of adult (n = 134), subadult (n = 57), of western Slovakia. Overall, software based on the highlighted marks measured 29 cranial features. Significant sexual dimorphism was observed for three features in adult individuals (width of the maxillary tooth row – right side “WMTRR”, maximum height of the mandibula excluding coronoid process “AMdm” and coronoid height of the mandibula “AMd”) and four features in subadults (length of the tooth row in the maxilla “LOSD”, “WMTRR”, length of the molar “LoM” and alveolar length of the lower molars “ALLM”). Results showed a significant positive relationship between body weight and cranial size in 18 of the 29 features. They also suggested a weak but significant positive effect of common vole abundance on cranium size (Chitty effect) likewise in 6 of the 29 features. In several cases, this effect affects, in addition to the abundance, the onset of sexual maturity of individuals.

The effect of air pollutants on COPD-hospitalized patients in Lanzhou, China (2015-2019).

Lanzhou is the largest heavy industrial city in northwest China and it is a typical geographical valley-like city. However, there are few studies on the relationship between air pollutants and COPD, and their respective sample sizes are small, resulting in inconsistent results. The aim of this study is to analyze the effects of air pollutants on COPD hospitalizations in Lanzhou, China. An ecological time series study with distributed lag non-linear model (DLNM) was used for analysis. Daily COPD hospitalization data in Lanzhou from 1 January 2015 to 31 December 2019 were collected from 25 hospitals, as well as air pollutant data and meteorological data. A total of 18,275 COPD hospitalizations were enrolled. For 10 μg/m3 increase in PM2.5, PM10, SO2, NO2, and 1 mg/m3 increase in CO at lag 07 day, the RR95%CI of COPD hospitalizations were 1.048 (1.030, 1.067), 1.008 (1.004, 1.013), 1.091 (1.048, 1.135), 1.043 (1.018, 1.068), and 1.160 (1.084, 1.242), respectively. The exposure-response curves between air pollutants (except O3-8h) and COPD hospitalizations were approximately linear with no thresholds. Female, and the harmful effect of PM on aged <65 years, the effect of gaseous pollutant on those aged ≥65 years, were stronger, particularly in the cold season. Exposure to air pollutants (except O3-8h) might increase the risk of COPD hospitalizations. O3-8h has a weak and unstable effect on COPD. Exposure to air pollutants (except O3-8h) increases the risk of COPD hospitalizations. O3-8h has a weak and unstable effect on COPD hospital admissions. The harmful effect of gaseous pollutants (except O3-8h) on COPD-hospitalized patients was stronger than that of PM.

Weak magnetic field effect on dilepton polarization in heavy-ion collisions

Weak magnetic field effect on dilepton polarization in heavy-ion collisions

Specialized Metabolites From the Husks of Rice Oryza sativa L. and Their Biological Activities.

Rice (Oryza sativa L.) husk harbors a substantial proportion of biological metabolites, as one of the most plentiful agriculture by-products in rice milling process, rice husk remains poorly utilized. As a continuing search for potential bioactive molecules from the husk of rice, a totally of twelve conponents (1-12), including six sterol ferulates (1-6), one flavonoid (7), one dipeptide (8), and four phenylpropanoid derivatives (9-12) were obtained. All the chemical structures were elucidated based on comprehensive spectroscopic data. Wherein, compounds 1 and 2 were yield as previous undescribed metabolites, and the comprehensive NMR data for compounds 3 and 4 were first presented in its entirety. Motivated by the similarity of the structural motifs of components 1-6 to that of reported sterol ferulates, the antioxidant and anti-inflammatory effects for compounds 1-6 were evaluated in vitro. Among them, compounds 5/6 had a significant antioxidant activity compare to that of vitamin E in both DPPH and reducing power assay up to the concentration 40 μg/ml; while compounds 1 and 2 exhibited weak suppressive effect on the production of nitric oxide, with the IC50 values of 53.27 ± 1.37 μM.

Changes in mean evapotranspiration dominate groundwater recharge in semi-arid regions

Abstract. Groundwater is one of the most essential natural resources and is affected by climate variability. However, our understanding of the effects of climate on groundwater recharge (R), particularly in dry regions, is limited. Future climate projections suggest changes in many statistical characteristics of the potential evapotranspiration (Ep) and the rainfall that dictate the R. To better understand the relationship between climate statistics and R, we separately considered changes to the mean, standard deviation, and extreme statistics of the Ep and the precipitation (P). We simulated the R under different climate conditions in multiple semi-arid and arid locations worldwide. Obviously, lower precipitation is expected to result in lower groundwater recharge and vice versa. However, the relationship between R and P is non-linear. Examining the ratio R/P is useful for revealing the underlying relation between R and P; therefore, we focus on this ratio. We find that changes in the average Ep have the most significant impact on R/P. Interestingly, we find that changes in the extreme Ep statistics have much weaker effects on R/P than changes in extreme P statistics. Contradictory results of previous studies and predictions of future groundwater recharge may be explained by the differences in the projected climate statistics.

Joint optimization of spatial correlation for space-constrained MIMO underwater optical wireless communication system in weak turbulence

For the space-constrained underwater installations, spatial correlation is an essential factor affecting the reliability of the underwater optical wireless communication (UOWC) system with multiple-input multiple-output (MIMO) technology. In this paper, a joint optimization method for the layout and transmit power allocation of the light-emitting diode (LED)-based UOWC system is proposed and demonstrated under the weak turbulent channel. To analysis the transmission performance of the MIMO UOWC system, a composite channel model incorporating absorption, scattering and weak turbulence effects is established, and the channel spatial correlation characteristics with various system parameters is analyzed based on this model. Among these parameters, we take a 9 × 9 MIMO UOWC system as an example to simulate the communication performance of the optimization method under different turbulence intensities. The simulation results show the optimized system exhibits a channel capacity improvement of 13bps/Hz compared to the original system at the signal-to-noise ratio (SNR) of 20 dB and the same turbulence intensity. Moreover, the SNR of jointly optimized system can achieve a gain of 5 dB at the same bit error rate (BER). By extending the joint optimization algorithm to a 16 × 16 MIMO UOWC system, the optimized SNR can also obtain a gain of 7.5 dB which effectively demonstrates the universality of the proposed joint optimization algorithm.

Impact of transferable β-lactamases and intrinsic AmpC amino acid substitutions on the activity of cefiderocol against wild-type and iron uptake-deficient mutants of Pseudomonas aeruginosa.

We aimed to analyse the interplay between impaired iron uptake and β-lactamases on cefiderocol resistance in Pseudomonas aeruginosa. Thirty-one transferable β-lactamases and 16 intrinsic P. aeruginosa AmpC (PDC) variants were cloned and expressed in wild-type (PAO1) and iron uptake-deficient (PAO ΔpiuC) P. aeruginosa backgrounds. MICs of cefiderocol and antipseudomonal β-lactams were determined by reference broth microdilution. Relative to PAO1, deletion of piuC caused a specific 16-fold decrease in cefiderocol activity but negligible effects on the activity of other β-lactams. Among transferable β-lactamases, SHV-12, KPC Ω-loop mutants, NDMs and OXA-15 showed cefiderocol MIC values above the clinical breakpoint (2 mg/L) when expressed in PAO1. When expressed in PAO ΔpiuC, these and the transformants harbouring PER-1, VEB-1, KPC-2, KPC-3, VIM-1, CMY-2, OXA-2 and OXA-14 showed increased MIC values from 16 to >256 mg/L. The PDC variants carrying the Ω-loop changes ΔP215-G222 (PDC-577), E219K (PDC-221 and PDC-558) and the H10 helix change L293P (PDC-219) had the greatest impact on cefiderocol resistance, with MICs of 2-4 mg/L in PAO1 and of up to 32-64 mg/L in PAO ΔpiuC. Widespread enzymes such as GES, CTX-M-9, CTX-M-15, VIM-2-like enzymes, IMPs, DHA-1, FOX-4, OXA-10, OXA-48 and the other PDC variants tested had weaker effects on cefiderocol resistance. We add evidence about the effect of the interplay between iron uptake and β-lactamases on the acquisition of cefiderocol resistance in P. aeruginosa. These findings may help to anticipate the emergence of resistance and optimize the use of cefiderocol against P. aeruginosa infections.

Phytochemical profiling and bioactivity analysis of Citrus japonica leaves volatile oil from Palestine

BackgroundExploring the therapeutic potential of unutilized plant parts from agricultural crops represents a promising strategy for discovering novel medications with high positive economic value. This study aimed to characterize the composition, antidiabetic, anti-obesity, antioxidant, and cytotoxic effects of volatile oil (VO) extracted from the leaves of Citrus japonica trees. This is the first research to assess the C. japonica VO’s anti-obesity, anti-lipase, and cytotoxic properties. Using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assays and gas chromatography–mass spectrometry (GC–MS) analysis, the components of VO and its capacity to suppress the growth of cancer and other abnormal cells were ascertained, respectively. Stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals, p-nitrophenyl butyrate (PNPB), and dinitrosalicylic acid (DNSA) assays were employed to determine antioxidant, anti-obesity, and antidiabetic activities, respectively.ResultsThe C. japonica leaf showed significant diversity in type and percentage of VO molecules. Overall, 45 compounds were identified in the VO, constituting 99.69% of the total oil composition. γ-Muurolene (28.12%), β-eudesmol (10.93%), γ-eudesmol (8.44%), germacrene B (7.39%), and elemol (7.27%) are the major characterized molecules. According to the inhibition percentage results of DPPH free radicals, porcine pancreatic lipase, and α-amylase, the VO exhibits strong antioxidant properties and weak inhibitory effects on lipase and α-amylase enzymes. The C. japonica VO showed a moderate cytotoxic effect against Hep3B and considerable activity on B16F1, CaCo-2, HeLa, MCF-7, and HepG2, with IC50 doses in the range of 69.7–171.96 µg/mL. The VO cytotoxic effect IC50 against the normal cell line LX-2 was 224.95 µg/mL.ConclusionThe current study collectively presented the chemical constituents of C. japonica leaf VO from Palestine for the first time and demonstrated its inhibitory effects against DPPH free radicals, porcine pancreatic lipase, and α-amylase. The results suggest that C. japonica leaf VO has the potential to be used as a natural supplement to prevent or treat cancer, as well as in the food industry as a natural antioxidant.Graphical

Synthesis and characterization of bioplastics based on silyated starch and acrylated epoxidized soybean oil

In the study, the bioplastics were prepared by coupling silylated starch with acrylated epoxidized soybean oil (AESO) at various curing temperatures. 3-aminopropyltriethoxy silane (APTES) was grafted onto starch by the condensation between Si-OH and C-OH. As demonstrated by FTIR and silica content analysis, starch was successfully modified by APTES. The compatibility between silylated starch and AESO was weak as observed by FESEM. The appearance of C-N bonds confirmed the reaction between AESO and silylated starch. An apparent increase of tensile strength from 8.03 MPa to 14.12 MPa was discovered when the bioplastics were cured from 80 °C to 120 °C. Opacity of the bioplastics was enhanced remarkably by AESO due to the incompatibility of silylated starch and AESO. Water resistance test showed that the bioplastics were less sensitive to water after the addition of AESO. The bioplastics maintained good biodegradability after the introduction of AESO. However, increasing the curing temperatures of the bioplastics yielded weak effects on the water resistance and enzymatic degradation of the bioplastics. The bioplastics with excellent mechanical and water-resistant properties were synthesized via the incorporation of AESO under high-temperature curing. The property changes are highly desirable for packaging applications.

Effects of precipitation changes and warming on vegetation–soil–microbial relationships in desert grasslands

Vegetation–soil–microbial relationships significantly affect global climatic and environmental changes. Fluctuations in temperature and precipitation caused by climate change are the driving forces of dynamic changes in vegetation–soil–microbial relationships. Our study was conducted in the desert grassland of Ningxia, China, and involved five levels of annual precipitation (33 % (R33), 66 % (R66), 100 % (RCK), 133 % (R133), and 166 % (R166)) and two temperature levels (within and outside the open-top chamber). Our objective was to determine how vegetation–soil–microbial relationships in desert grasslands respond to changes in precipitation and warming. Our results showed that precipitation was positively correlated with above-ground living and root biomass, and soil organic carbon. R166 had the strongest effect on the correlation between vegetation, soil, and microbes, whereas R33 had the weakest effect. Temperature was positively correlated with soil microbial α-diversity, and the effect of warming on the correlation among vegetation, soil, and microbes was less significant than under natural temperature. The combination of precipitation and warming was positively correlated with the above-ground living biomass and soil respiration. The correlation effects of the combination of precipitation and warming on vegetation, soil, and microbes were more substantial than those of precipitation and warming. Our findings provide a theoretical basis for the formulation of reasonable response strategies for desert steppe ecosystems.

Climate change driven by LUCC reduced NPP in the Yellow River Basin, China

Anthropogenic activities and the resulting climate change affect the type, structure, and function of ecosystems. Understanding vegetation dynamics related to anthropogenic activities and climate change is critical to address the terrestrial carbon cycle in the context of global warming. The objective of this study is to quantify the effects of human-induced land use and land cover change (LUCC) and LUCC-induced climate change on terrestrial net primary productivity (NPP) in the Yellow River Basin (YRB) during 2000–2020 using Weather Research and Forecasting (WRF) model and Integrated Biosphere Simulator (IBIS) model through different experimental scenarios. Results indicated that LUCC can cause an increase in NPP of 1.2 ± 0.67 gC m−2 yr−1 in YRB. The increased precipitation and decreased temperature due to LUCC showed weak negative effect on annual mean NPP in YRB (−0.2 ± 0.74 gC m−2 yr−1). The coupling of LUCC and LUCC-induced climate change increased annual mean NPP approximately 0.6 ± 0.86 gC m−2 yr−1. The impacts of LUCC and LUCC-induced climate change and their coupling effects on NPP were greatest in spring, increasing NPP by 5.1 ± 0.51, 3.4 ± 0.41, and 6.1 ± 0.79 gC m−2 yr−1, respectively. These findings provide important guidance for the sustainable and adaptive management of terrestrial ecosystems in river basin in the context of global change.

Eye Movement Evaluation of Pedestrians' Mobile Phone Usage at Street Crossings

Vision is one of the most important human senses, accounting for most of the external information pedestrians receive while crossing the street. However, distracted mobile phone usage during street crossing consumes pedestrians’ cognitive resources and diverts their visual attention. As a result, pedestrians may be unable to fully concentrate on observing the traffic environment and effectively planning their crossing path and behavior. This study evaluated the effect of pedestrian behavioral activities at street crossings on eye-movement (EM) characteristics. The crossing tasks were natural behavior, voice call, text messaging, and listening to music. The tasks were further categorized as simple or complex. A total of 29 participants were recruited in Nanjing: 18 males (62.1%) and 11 females (37.9%) with an average age of 23.59 years (SD = 2.44). The Friedman test was used to analyze differences in saccade frequency, fixation time, browsing number, and browsing time across different scenarios. Text messaging had the most significant impact on pedestrians’ EM characteristics, followed by voice call; music listening had a relatively weaker effect. Secondary task difficulty influenced the percentage of browsing, viewing, and to some extent gaze time. On the other hand, music rhythm and style only partially influenced the percentage of gaze and gaze time. Mobile phones substantially affected pedestrians’ EM characteristics and attention allocation for the same level of secondary task difficulty. These findings contribute to a better understanding of pedestrians’ visual characteristics under distracted mobile phone usage conditions and provide valuable insights for developing appropriate measures to enhance pedestrian safety.

Microstructure, deformation and fracture mechanism of Mg-Gd-Y-Zn-Zr alloy with different rolling routes during tension

The microstructure, deformation and fracture mechanism of unidirectional rolling (UR) and cross rolling (CR) Mg-4.7Gd-3.4Y-1.2Zn-0.5Zr alloy during tension were studied. Both rolled alloys exhibit typical bimodal microstructures, with the difference being that UR alloy has elongated grains containing rod LPSO phase, while CR alloy has relatively rounded deformed grains containing lamellar LPSO phase. After tension until fracture, the LPSO phase morphology of the two alloys remains unchanged. CR alloy exhibits a higher yield strength and lower elongation than UR alloy. Although the higher average basal <a> slip Schmid factor result in the lower yield strength of UR alloy, the activation of the high proportion of non-basal slip is responsible for its higher elongation. UR alloy and CR alloy exhibit ductile fracture and quasi cleavage fracture characteristics, respectively. For UR alloy, a variety of dislocations accumulated near grain boundary and the weak slip transfer effects between grains both contributes to the propagation of grain boundary cracks. However, the effects of weak interfacial bonding between metastable lamellar LPSO phase and matrix, along with the similar orientation and higher geometric compatibility of CR alloy, lead to the rapid spread of transgranular cracks.

Proanthocyanidins-based adjuvant for enhanced immune responses of SARS-CoV-2 subunit vaccine

Aluminum-containing adjuvants have been widely used in human vaccines, such as anti-COVID-19 vaccine, to enhance antigen-specific immune responses. However, a major limitation of aluminum adjuvants in clinical application is that they typically enhance humoral immune responses but have weaker effects on cellular immune responses. Therefore, there has been a continuous and active pursuit of novel adjuvants that can address the shortcomings of traditional adjuvants and improve vaccine efficacy. In this paper, we proposed a novel vaccine-adjuvant system utilizing the convenient physical mixing of natural proanthocyanidins (PCs) and its derivative with a recombinant RBD subunit vaccine, which induced comparable humoral immune responses compared to aluminum adjuvant. In the context of cellular immunity, PCs modified with 4-bromomethyl phenylboronic acid not only enhanced the maturation and migration of dendritic cells but also improved the antigen uptake and presentation capacity of monocytes, leading to robust activation of immune cells, particularly involving CD4+ and CD8+ T cells, thereby demonstrating a clear Th1/CTL response bias. In general, PCs andtheir derivatives could be potential innovative natural adjuvants which effectively balance the Th1/Th2 immune response to recompense for the deficiency of aluminum adjuvant, and our study also offers an approach to discovering safe and efficient natural adjuvants.

Stability and Hopf Bifurcation Analysis of a Predator–Prey Model with Weak Allee Effect Delay and Competition Delay

The purpose of this paper is to study a predator–prey model with Allee effect and double time delays. This research examines the dynamics of the model, with a focus on positivity, existence, stability and Hopf bifurcations. The stability of the periodic solution and the direction of the Hopf bifurcation are elucidated by applying the normal form theory and the center manifold theorem. To validate the correctness of the theoretical analysis, numerical simulations were conducted. The results suggest that a weak Allee effect delay can promote stability within the model, transitioning it from instability to stability. Nevertheless, the competition delay induces periodic oscillations and chaotic dynamics, ultimately resulting in the population’s collapse.

Neurotoxicity, Neuroprotection, In Vitro MAOA/MAOB Inhibitory Activity Assessment, Molecular Docking, and Permeability Assay Studies of Newly Synthesized Hydrazones Containing a Pyrrole Ring.

Neurodegenerative diseases such as Parkinson's and Alzheimer's continue to be some of the most significant challenges in modern medicine. Recent research related to the molecular mechanisms of parkinsonism has opened up new approaches to antiparkinsonian therapy. In response to this, we present the evaluation of the potential neuroprotective and MAOA/MAOB inhibitory effects of newly synthesized hydrazones, containing a pyrrole moiety in the carboxyl fragment of the structure. The substances were studied on different brain subcellular fractions, including rat brain synaptosomes, mitochondria, and microsomes. The single application of 50 µM of each compound to the subcellular fractions showed that all substances exhibit a weak neurotoxic effect, with 7b, 7d, and 8d being the least neurotoxic representatives. The corresponding neuroprotective and antioxidant effects were also evaluated in different injury models on subcellular fractions, single out 7b, 7d, and 8d as the most prominent derivatives. A 1 µM concentration of each molecule from the series was also studied for potential hMAOA/hMAOB inhibitory effects. The results revealed a lack of hMAOA activity for all evaluated structures and the appearance of hMAOB effects, with compounds 7b, 7d, and 8d showing effects similar to those of selegiline. The best hMAOB selectivity index (>204) was determined for 7d and 8d, distinguishing these two representatives as the most promising molecules for further studies as potential selective MAOB inhibitors. The performed molecular docking simulations defined the appearance of selective MAOB inhibitory effects based on the interaction of the tested molecules with Tyr398, which is one of the components of the aromatic cage of MAOB and participated in π-π stabilization with the aromatic pyrrole ring. The preliminary PAMPA testing indicated that in relation to the blood-brain barrier (BBB) permeability, the tested pyrrole-based hydrazones may be considered as high permeable, except for 8a and 8e, which were established to be permeable in the medium range with -logP of 5.268 and 5.714, respectively, compared to the applied references.

Remittances, inclusive finance and governance in selected African countries: empirical insights from the COVID-19 pandemic

This research intends to explore the effects of inclusive finance on remittances and how these international flows impact economic growth in selected countries from Africa from 1996 to 2020 from 1996 to 2020. As per the results of panel dynamics estimation, inclusive finance positively impacts remittances. Furthermore, remittances significantly and positively impact economic growth in countries with solid governance effectiveness. However, they do not affect economic growth in weak governance effectiveness groups. Finally, COVID-19 positively affects remittance receipt, and negatively affects economic growth. Inclusive finance offerings are a crucial transmission channel in receiving remittances to African countries, and governance effectiveness plays a substantial role here.

Weak effects of prebiotically plausible peptides on self-triphosphorylation ribozyme function.

Catalytic RNAs (ribozymes) were central to early stages of life on earth. The first ribozymes probably emerged in the presence of prebiotically generated peptides because amino acids can be generated under abiotic conditions, and amino acids can oligomerize into peptides under prebiotically plausible conditions. Here we tested whether the presence of prebiotically plausible peptides could have aided the emergence of ribozymes, by an in vitro selection of self-triphosphorylation ribozymes from random sequence in the presence of ten different octapeptides. These peptides were composed of ten different, prebiotically plausible amino acids, each as mixture of d- and l-stereoisomers. After five rounds of selection and high throughput sequencing analysis, ten ribozymes that appeared most promising for peptide benefits were tested biochemically for possible benefits from each of the ten peptides. The strongest peptide benefit enhanced ribozyme activity by 2.6-fold, similar to the effect from an increase in the pH by one-half unit. Four arbitrarily chosen ribozymes from a previous selection without peptides showed no significant change in their activity in the presence of the ten peptides. Therefore, the used prebiotically plausible peptides - peptides without evolutionarily optimized sequence, without cationic or aromatic side chains - did not provide a strong benefit for the emergence of ribozyme activity. This finding stands in contrast to previously identified polycationic peptides, conjugates between peptides and polyaromatic hydrocarbons, and modern mRNA encoded proteins, all of which can strongly increase ribozyme function. The results are discussed in the context of origins of life.

Divergent views of party positions: How ideology and own issue position shape party perception through convergence and divergence processes

The current research explores how respondents’ ideology influences their perception of political parties’ stances on various issues. Additionally, we examine how three distinct indicators of ideological strength—congruence between ideology and party affiliation, level of education, and engagement in political activities—affect these perceptions. Our empirical analyses rely on data from the 1968–2012 Cumulative American National Election Study dataset, which captures respondents’ views on the stances of US political parties regarding ten key issues. We find that, after controlling for respondents’ own issue positions, (i) perceptions of the positions held by the opponent party are strongly influenced by respondents’ ideologies, and (ii) this influence is more pronounced among individuals with stronger ideological convictions, as indicated by the three aforementioned indicators. Conversely, when examining perceptions of one’s favored party, ideology demonstrates a weak and inconsistent effect across the three markers of ideological strength. We discuss theoretical frameworks that may elucidate these findings, their implications for understanding political polarization, and we acknowledge limitations related to the dataset’s characteristics.

Enhancing the ketonization efficiency of biomass through selective conversion of furanic compounds

Catalytic ketonization of biomass is an effective approach for the deoxygenation of bio-oil and the enrichment of high-purity ketone products. However, the bio-oil contains a large amount of furanic components with oxygenated side groups (e.g., furfural, furfuralcohol, etc.), which severely hinders the efficiency of the ketonization reaction. In response to this challenge, this study employed Pd-based catalysts for selective conversion of furfural into "keto-friendly" components, thereby mitigating their inhibitory effects. Initially, three morphologies of CeO2 (the main catalyst for ketonization) were selected to investigate their influence on furfural conversion. It was found that the products were mainly furfural (exceeding 86 %), with only up to approximately 13 % of "keto-friendly" products (mainly furans) detected, indicating that pure CeO2 exhibits a weak catalytic effect on the effective conversion of furfural. Compared with pure CeO2, the yield of "keto-friendly" products increased significantly when 1 wt% Pd was loaded, demonstrating the excellent catalytic performance of Pd in the effective conversion of furfural. Co-doping of Pd and Zr (5 wt%) on CeO2 further increased the "keto-friendly" products to 66 %, suggesting a synergistic effect of Pd and Zr. Mechanism analysis revealed that Pd promotes the formation of furans and benzenes by enhancing the decarbonylation of furfural and subsequent furan ring opening reactions, while the competing carbonyl hydrogenation pathway is weakened. The findings of this study will be beneficial for enhancing the biomass ketonization conversion, thereby providing valuable references for the high-value utilization of biomass.