Abstract The monitoring of micro-defects or external actions induced vacuum degradation in aerospace vacuum vessels is an important challenge. A vacuum-process monitoring method based on quasi-distributed fiber Bragg grating (FBG) sensing technology is proposed. Due to the influence of environmental noise and vacuum pump operation noise, the raw signals measured by FBG sensors contain a large amount of noises, which affects the measurement accuracy and data analysis. Therefore, the wavelet threshold (WT) denoising method is proposed to analyze the influence of noises on the monitoring signals measured by two different kinds of FBG sensors. The evaluation of the monitoring signals after denoising indicates that the proposed method can effectively remove the noise and significantly improve signal quality. The highest signal-to-noise ratio of the processed signals can reach 37.61 dB and the mean square error is 3.68 × 10−7, while retaining the key features of the original signal. The proposed WT denoising method demonstrates better performance and feasibility compared with moving average filtering and Kalman filtering methods. The study provides critical supports for improving the performance and reliability of the vacuum vessel monitoring system.