Wavefront Analysis Research Articles

Corneal Epithelial Wavefront Error as a Novel Diagnostic Marker for Epithelial Basement Membrane Dystrophy.

Synopsis: Corneal epithelial wavefront error and epithelial thickness variance qualify as highly sensitive and specific biomarkers for epithelial basement membrane dystrophy (EBMD). The biomarkers show a normalization after treatment of EBMD with phototherapeutic keratectomy. Purpose: To gauge the diagnostic value of epithelial basement membrane dystrophy (EBMD), a novel spectral-domain optical coherence tomography (SD-OCT)-based imaging modality for simultaneous morphological (thickness profile) and refractive (optical wavefront) assessment of the corneal epithelial layer in one of the most common but often underdiagnosed corneal dystrophies. Methods: In this prospective observational study, a total of 32 eyes of 32 patients diagnosed with EBMD and 32 eyes of 32 healthy control subjects were examined with high-resolution anterior segment SD-OCT (MS-39; CSO, Florence, Italy). Various epithelial thickness and epithelial wavefront-derived terms were compared between groups and receiver operating characteristic (ROC) curves were computed to analyze the diagnostic capacity of the respective parameters. A total of 17 of 32 EBMD patients underwent treatment with phototherapeutic keratectomy (PTK) and were followed up for 3 months. Results: Epithelial thickness variance (60.4 ± 56.7 µm versus 7.6 ± 6.1 µm) and interquartile range (11.0 ± 6.9 versus 3.3 ± 1.9 µm) were markedly elevated in EBMD patients as compared with healthy controls (both with p < 0.001). Epithelial wavefront analysis showed a highly statistically significant excess in all examined aberration terms in EBMD patients (all with p < 0.001). Significantly greater areas under the curve (AUCs) were yielded by the epithelial wavefront-derived parameters (e.g., total epithelial wavefront error: AUC = 0.966; 95% confidence interval (CI) 0.932-1) than by the epithelial thickness-derived parameters (e.g., variance: AUC = 0.919; 95% CI 0.848-0.990). Conclusions: Corneal epithelial wavefront aberrometry proved valuable as an objective biomarker for EBMD, with high sensitivity and specificity. PTK resulted in a reduction of morphological and refractive epithelial irregularities in EBMD.

A Framework for Iterative Phase Retrieval Technique Integration into Atmospheric Adaptive Optics—Part I: Wavefront Sensing in Strong Scintillations

The objective of this study, which is divided into two parts, is twofold: to address long-standing challenges in the sensing of atmospheric turbulence-induced wavefront aberrations under strong scintillation conditions via a comparative analysis of several basic scintillation-resistant wavefront sensing (SR-WFS) architectures and iterative phase retrieval (IPR) techniques (Part I, this paper), and to develop a framework for the potential integration of SR-WFS techniques into practical closed-loop non-astronomical atmospheric adaptive optics (AO) systems (Part II). In this paper, we consider basic SR-WFS mathematical models and phase retrieval algorithms, tradeoffs in sensor design and phase retrieval technique implementation, and methodologies for WFS parameter optimization and performance assessment. The analysis is based on wave-optics numerical simulations imitating realistic turbulence-induced phase aberrations and intensity scintillations, as well as optical field propagation inside the SR-WFSs. Several potential issues important for the practical implementation of SR-WFS and IPR techniques, such as the requirements for phase retrieval computational grid resolution, tolerance with respect to optical element misalignments, and the impact of camera noise and input light non-monochromaticity, are also considered. The results demonstrate that major wavefront sensing requirements desirable for AO operation under strong intensity scintillations can potentially be achieved by transitioning to novel SR-WFS architectures, based on iterative phase retrieval techniques.

Ocular, Corneal and Internal Wavefront Analysis in Refractive Surgery Candidates

Ocular, Corneal and Internal Wavefront Analysis in Refractive Surgery Candidates

Retinal Image Quality Through an Operating Microscope With Wavefront Shaping Extended Depth of Focus Intraocular Lens in Model Eye

To compare the quality of images of gratings placed in a model eye viewed through an extended depth of focus (EDoF) intraocular lens (IOL) to that of diffractive bifocal IOL or monofocal IOL. Experimental laboratory investigation. Nondiffractive wavefront shaping EDoF (CNAET0, Alcon Laboratories), echelette-designed EDoF (ZXR00V, Johnson & Johnson Vision), diffractive bifocal IOL with low power addition (SV25T, Alcon Laboratories), or monofocal IOL (CNA0T0, Alcon Laboratories) was placed in a fluid-filled model eye. A United States Air Force Resolution Grating Target was glued to the posterior surface of the model eye and viewed through a flat or a wide-angle contact lens. The contrast of the gratings viewed through the EDoF or multifocal IOLs was compared to that through the monofocal IOL. A wavefront analyzer was used to measure the spherical power of the central 4.5 mm optics of the EDoF, multifocal, and monofocal IOLs. The distribution of the dioptric power and the dioptric power map were compared. The gratings observed through the flat contact lens with CNAET0, ZXR00V, or SV25T were slightly blurred when viewed through the multifocal optics. The blurred area was in the circumferential area of CNAET0, the central area of SV25T, and the peripheral area of ZXR00V. The mean contrast was 0.258 ± 0.020 for CNAET0, 0.227 ± 0.025 for ZXR00V, and 0.221 ± 0.020 for SV25T for the 16.0 cyc/mm grating. The contrast was significantly lower for ZXR00V (P = .004) and SV25T (P = .004) than 0.303 ± 0.015 for CNA0T0 but the differences were not significant for CNAET0. For the wide-angle contact lens, the contrast for CNAET0 was 0.182 ± 0.009, for ZXR00V was 0.162 ± 0.011, and for SV25T was 0.163 ± 0.007 for the 16.0 cyc/mm grating, and none was significantly different from 0.188 ± 0.012 for CNA0T0. The dioptric variations of CNAET0 indicated a ring-shaped area of higher power corresponding to the circumferential blurred zone observed through the flat contact lens. The wavefront shaping and echelette-designed EDoF-IOLs reduce the contrast of the grating more than the monofocal IOL when viewed through the flat contact lens. The degree of reduction depended on the design of the extended-focus optics. The difference was less through the wide-angle contact lens.

Wavefront analysis and phase correctors design using SHADOW.

Knife-edge imaging is a successful method for determining the wavefront distortion of focusing optics such as Kirkpatrick-Baez mirrors or compound refractive lenses. In this study, the wavefront error of an imperfect elliptical mirror is predicted by developing a knife-edge program using the SHADOW/OASYS platform. It is shown that the focusing optics can be aligned perfectly by minimizing the parabolic and cubic coefficients of the wavefront error. The residual wavefront error provides precise information about the figure/height errors of the focusing optics suggesting it as an accurate method for in situ optical metrology. A Python program is developed to design a customized wavefront refractive corrector to minimize the residual wavefront error. Uniform beam at and out of focus and higher peak intensity are achieved by the wavefront correction in comparison with ideal focusing. The developed code provides a quick way for wavefront error analysis and corrector design for non-ideal optics especially for the new-generation diffraction-limited sources, and saves considerable experimental time and effort.

Correlation of Dysfunctional Lens Index with Lens Opacification System III in Age Related Cataract

Purpose: Age-Related changes in crystalline lens opacity and lens density contribute to formation of higher order aberrations resulting in reduced quality of vision. Precise quantification of cataract is important for predicting phacodynamics and educating patient. The iTrace(a ray-tracing aberrometer) provides Dysfunctional Lens Index (DLI). This study from Pakistan investigates the relationship between LOCS III and DLI in senile cataract. Study Design: Correlational study. Place and Duration of Study: Hashmanis Hospital, Karachi from March 2021 to May 2021. Methods: This study included 44 patients with age-related cataract. Demographic characteristics and complete ophthalmic examination of eyes including Best Corrected Visual Acuity (BCVA) and slit lamp biomicroscopy were performed. Age related cataracts were graded using the Standard technique of LOCS III. I-Trace was utilized for wave front analysis to calculate DLI. Results: BCVA and LOCS III nuclear opalescence score had strongest positive linear correlation (r=0.433, P&lt;0.01). DLI displayed a strong significant negative correlation to LOCS III Cortical Cataract (C) and LOCS III Posterior Sub-Capsular Cataract (P) score (r=-0.415 and r=-0.694; respectively). Conclusion: BCVA had insignificant and small to no correlation to LOCS III C score and P score. Whereas, DLI showed the strongest significant correlation to LOCS III C score and P score. Patient's optical quality determined by visual symptoms are more closely associated to DLI parameter as compared to LOCS III classification. DLI can provide a better objective way to elevate age related cataract, monitor the progression and determine phacodynamics.

Suboptimal visual outcome after femto-LASIK ablation in a high myopic patient.

A 28-year-old nurse had an aberration-free femto-laser in situ keratomileusis (LASIK) performed for her myopia of -6.25 -0.50 × 096 and -6.75 -0.50 × 175 in the right and left eye, respectively. Corrected distance visual acuity (CDVA) preoperatively was 20/16. Preoperatively, there were no abnormalities on Scheimpflug imaging, and a pachymetry of 585 μm was measured in both eyes. Flap thickness was 115 μm. The patient was quite nervous during the surgery. Since the surgery, her uncorrected distance visual acuity (UDVA) and CDVA are suboptimal at 20/30 and 20/20 in the right eye, and 20/20 and 20/16 in the left eye. 3 months postoperatively, there is a stable manifest refraction of +0.25 -1.25 × 030 and +0.25 -0.00 × 0. The keratometric astigmatism in the Scheimpflug imaging is 1.2 diopter (D) × 114 and 0.4 D × 78 in the right and left eyes, respectively (FIgures 1 and 2). Thinnest pachymetry is 505 μm and 464 μm in the right and left eye, respectively. Her wavefront analysis shows refraction in a 6 mm zone of -0.99 -1.22 × 32 and -0.91 -0.36 × 136. The cycloplegic refraction is 1.25 -1.00 × 023 and +1.00 -0.25 × 006 (Figures 3 and 4). What is the cause of the suboptimal visual outcome in this case? What would be your treatment strategy to improve visual outcome?

Evolution of shock waves in dusty nonideal gas flow with magnetic field

Abstract This paper deals with the study of propagation of shock waves in 2-D steady supersonic magnetogasdynamics flow of nonideal dusty gas using wavefront analysis method. We derived the transport equation, which determines the condition for the shock formation. Our aim is to analyze the effect of interaction of dust particles with magnetic field in nonideal gas on the evolution of shock formation and to examine how the flow patterns of the disturbance vary with respect to the variations in the physical parameters of the medium. It is found that the presence of magnetic field plays an essential role in the wave propagation phenomena. The nature of the solution with respect to the Mach number is analyzed, and it is examined how the shock formation distance changes with an increase or decrease in the value of Mach number. Also, the combined effect of nonidealness, magnetic field, and dust particles on the shock formation distance is elucidated and examined how the formation of shocks is affected by the increase in the value of corresponding physical parameters.

A comparison of next-generation turbulence profiling instruments at Paranal

ABSTRACT A six-night optical turbulence monitoring campaign has been carried at Cerro Paranal observatory in 2023 February and March to facilitate the development and characterization of two novel atmospheric site monitoring instruments – the ring-image next-generation scintillation sensor (RINGSS) and 24-h Shack Hartmann image motion monitor (24hSHIMM) in the context of providing optical turbulence monitoring support for upcoming 20–40 m telescopes. Alongside these two instruments, the well-characterized Stereo-SCIDAR and 2016-MASS-DIMM were operated throughout the campaign to provide data for comparison. All instruments obtain estimates of optical turbulence profiles through statistical analysis of intensity and wavefront angle-of-arrival fluctuations from observations of stars. Contemporaneous measurements of the integrated turbulence parameters are compared and the ratios, bias, unbiased root mean square error, and correlation of results from each instrument assessed. Strong agreement was observed in measurements of seeing, free atmosphere seeing, and coherence time. Less correlation is seen for isoplanatic angle, although the median values agree well. Median turbulence parameters are further compared against long-term monitoring data from Paranal instruments. Profiles from the three small-telescope instruments are compared with the 100-layer profile from the stereo-SCIDAR. It is found that the RINGSS and SHIMM offer improved accuracy in characterization of the vertical optical turbulence profile over the MASS-DIMM. Finally, the first results of continuous optical turbulence monitoring at Paranal are presented which show a strong diurnal variation and predictable trend in the seeing. A value of 2.65 arcsec is found for the median daytime seeing.

Wave-front reconstruction and analysis of far-field high-order harmonics from relativistic plasma surfaces

Wave-front reconstruction and analysis of far-field high-order harmonics from relativistic plasma surfaces

Intra-Observer and Inter-Observer Variability of Intraocular Lens Measurements Using an Interferometry Metrology Device.

The NIMO TEMPO (Lambda-X, Nivelles, Belgium) is a novel, user-friendly and compact device designed for in vitro optical analysis of refractive and diffractive intraocular lenses (IOLs). This device analyzes the IOL wavefront and generates a synthetic eye model for numerical computation. The objective of this study was to evaluate the precision of this innovative device. Intra- and inter-observer variability were calculated using a two-way analysis of variance (ANOVA) after conducting ten measurements of eight different IOL models, with each measurement being repeated by three distinct operators (resulting in a total of 30 measurements for each IOL). The device demonstrated satisfactory intra- and inter-observer variability in evaluating IOL power and modulation transfer function (MTF) profiles, with values of 0.066 and 0.078 diopters for IOL power and 0.018 and 0.019 for MTF measurements, respectively. Furthermore, this hybrid optical and numerical in vitro IOL wavefront analyzer appears to have several advantages over conventional optical bench devices. It reduces the need for operator manipulation, and allows for numerical modeling of various optical environments, including cornea models and apertures. In conclusion, this novel metrology device designed for refractive and diffractive IOLs appears to provide a satisfactory precision, making it a promising tool in the field of IOL metrology.

Современные подходы к хирургии катаракт с высокой остротой зрения на основании анализа волнового фронта

Relevance. Until recently, visual acuity was the main criterion for determining the timing of surgery, but already in the early stages of cataract development, patients may suffer from reduced image quality, which affects the quality of life (“night” myopia, light scattering, blurring). Deterioration in visual function in these patients may be explained by refractive errors. Analysis of internal higher-order aberrations resulting from slight opacification of the lens is important for determining the effect of media opacity on wavefront aberrations (WF) and for determining the indications and timing of surgical treatment, especially in patients with high visual acuity. Purpose. Evaluate the optical system of the eye with initial cataracts and high visual acuity. Evaluate the wavefront and its aberrations, contrast sensitivity and Shtrel coefficient. Material and methods. The study included 111 eyes with cataracts and 42 eyes without signs of cataracts (control group). Patients aged on average 57±5.3 years. Wavefront analysis was performed using an iTrace ray tracing aberrometer (Tracey Tech., USA) in a dark room under maximum drug-induced mydriasis. In each group, total, corneal, and internal wavefront aberrations were measured at a pupil diameter of 6.0 mm. Higher order aberrations were analyzed using Zernike polynomials (3rd to 5th order). The modulation transfer function (MTF) at different spatial frequencies (0–30 c/deg) and the Strehl coefficient in patients in the study groups were also assessed. Results. Total and internal higher-order wavefront aberrations were significant in different cataract groups compared with control patients, while higher-order corneal aberrations were not statistically different. We noted a higher level of total and internal aberrations in the group of patients with posterior subcapsular cataract. In this regard, patients with posterior subcapsular cataract require surgical treatment at an earlier stage, despite high visual acuity. Conclusion. We recommend assessing the optical quality of vision and wavefront aberrations when observing early cataracts in order to decide whether to perform surgery at an earlier date. Key words: initial cataract, quality of vision, higher order aberrations, internal wavefront aberrations

Optical Quality and Higher Order Aberrations of Refractive Extended Depth of Focus Intraocular Lenses.

To compare the optical quality and higher order aberrations of four different refractive extended depth of focus intraocular lens (EDOF IOL) models (Lentis Comfort [Teleon Surgical BV], MiniWell (SIFI), LuxSmart [Bausch & Lomb], and AcrySof IQ Vivity [Alcon Laboratories, Inc]) and a monofocal IOL (Tecnis ZCB00; Johnson & Johnson Surgical Vision, Inc). An optical metrology instrument (OptiSpheric IOL PRO2; Trioptics GmbH) was used to study image quality metrics of the different IOLs. The modulation transfer function (MTF) was measured at pupil sizes 1 to 5 mm in 1-mm steps. Area under the MTF and simulated visual acuity were calculated for different pupil diameters. Wavefront aberrations were measured with the SHS Ophthalmic device (Optocraft GmbH), which features a Hartmann-Shack sensor. All EDOF lenses yielded a simulated far visual acuity of 0.00 logMAR (20/20 Snellen) or better. At the 0.20 logMAR visual acuity level, the EDOF IOLs showed an increased depth of focus of at least 0.75 diopters compared to the monofocal IOL. Pupil dependency was more pronounced with the MiniWell, LuxSmart, and Vivity, whereas the Lentis showed a more consistent behavior at different apertures. The wavefront measurement revealed increased central aberrations for the MiniWell, LuxSmart, and Vivity IOL compared to the monofocal control. All EDOF IOLs demonstrated increased depth of focus while maintaining good simulated visual acuity at the far focus. Pupil dependency differed between the IOL models. The wavefront analysis revealed the complex design of the different EDOF IOLs with several zones with varying aberrations. [J Refract Surg. 2023;39(10):668-674.].

Explantation of a light-adjustable intraocular lens: case report with laboratorial analyses

Introduction: A case in which a light-adjustable lens (LAL) underwent explantation and extensive laboratory analyses is reported. Patient and Clinical Findings: A 61-year-old man underwent uneventful cataract surgery with in-the-bag implantation of a first-generation LAL in the right eye. Examination on the second postoperative day revealed limbus-to-limbus corneal edema, moderate anterior chamber cells, and a mid-dilated, minimally responsive pupil, suggesting toxic anterior segment syndrome (TASS). Diagnosis, Intervention, and Outcomes: Endothelial keratoplasty was performed 2 months after LAL implantation. The patient reported noncompliance with required UV-protective eyewear, and an attempted light adjustment confirmed macromer reserve depletion, likely secondary to ambient UV contamination. Gross and microscopic examinations of the explanted LAL showed a decentered round elevation on the optic. The light transmittance (%T) curve was normal, with 95.9%T on average in the visible spectrum. Optical coherence tomography revealed irregular curvatures of the anterior and posterior optic surfaces. Wavefront analysis displayed aberrations and large power variations, which corresponded to decreased focus and contrast through the optic. Conclusions: To the authors' knowledge, this is the first reported case of LAL implantation complicated by TASS, leading to a prolonged clinical course and nonadherence to proprietary UV-protective spectacles. Extensive laboratory analyses of the explanted LAL demonstrated findings that can be expected with uncontrolled polymerization of the LAL.

Wavefront detection performance analysis of plenoptic sensor

Wavefront detection performance analysis of plenoptic sensor

Efficacy of estimations of Hartmann-Shack sensors in small pupil sizes.

The purpose of this study was to evaluate the in vivo efficacy of the estimations of wavefront analyzers using Hartmann-Shack technology to measure optical aberrations when the pupil size is smaller than the evaluated pupil area. Patients implanted with the monofocal ZCB00 intraocular lens (Johnson and Johnson) were examined with the KR-1W Wavefront Analyzer (Topcon) without pharmacological mydriasis and with it afterward. Optical aberrations were analyzed considering a 4-mm pupil and a 6-mm pupil for both examinations. Sixty-six eyes of 33 patients with a mean axial length of 23.35 ± 0.91 mm were assessed. The mean pupil diameter at the baseline examination was 5.05 ± 0.88 mm and under pharmacological mydriasis, it was 6.29 ± 0.84 mm. Outcomes were similar with and without dilation in the 4-mm comparison. However, there was a great disparity in the 6-mm comparison. Most of the values obtained under mydriasis were statistically lower than at baseline (P < 0.05). The iris interferes with measurements of wavefront aberrations, and therefore, real pupil size should always be checked before evaluating optical aberrations with Hartman-Shack sensors. When pupil size is smaller than the analyzed diameter, ocular, and internal, and sometimes, corneal aberrations are estimated far more positive than real values.

Comparison of corneal aberrations from anterior segment swept source OCT versus Placido-topography combined spectral domain OCT in cataract patients

BackgroundTo comprehensively evaluate the agreement of component corneal aberrations from the newly updated wavefront analysis software of a swept-source optical coherence tomographer (SS-OCT) and a referential Placido-topography combined OCT device in elderly cataract patients.MethodsRetrospective study including 103 eyes from 103 elderly patients scheduled for cataract surgery that were measured on the same day with a SS-OCT (Heidelberg Engineering, Germany) device and a Placido-topography combined OCT device (CSO, Italy). Anterior, total, and posterior corneal wavefront aberrations were evaluated for their mean differences and limits of agreement (LoA) via Bland-Altman plots. Vector analysis was additionally employed to compare corneal astigmatism measurements in dioptric vector space.ResultsMean differences of all corneal aberrometric parameters did not exceed 0.05 μm. Total corneal aberrations were not significantly different from 0 except for vertical coma (− 0.04 μm; P = 0.003), spherical aberration (− 0.01 μm, P < 0.001), and root mean square (RMS) higher-order aberration (HOA) (0.03 μm, P = 0.04). The 95% LoA for total corneal aberration parameters between both devices were − 0.46 to 0.42 μm for horizontal astigmatism, − 0.37 to 0.41 μm for oblique astigmatism, − 0.19 to 0.17 μm for oblique trefoil, − 0.33 to 0.25 μm for vertical coma, − 0.20 to 0.22 μm for horizontal coma, − 0.22 to 0.20 μm for horizontal trefoil, − 0.11 to 0.08 μm for spherical aberration, and − 0.22 to 0.28 μm for RMS HOA. Vector analysis revealed no statistically significant mean differences for anterior, total, and posterior corneal astigmatism in dioptric vector space.ConclusionIn eyes undergoing cataract surgery with a regular elderly cornea, corneal wavefront analysis from the SS-OCT device showed functional equivalency to the reference device. Nevertheless, clinically relevant higher order aberration parameters should be interpreted with caution for surgical decision-making.

Clinical prospective intra-individual comparison after mix-and-match implantation of a monofocal EDOF and a diffractive trifocal IOL.

To assess intra-individually visual acuity (VA) and subjective outcome after mix-and-match implantation of a monofocal EDOF IOL and a diffractive trifocal IOL. The monofocal EDOF Isopure IOL was implanted in the dominant eye and the trifocal FineVision HP IOL in the non-dominant eye. Postoperative evaluation included VA at various distances, contrast acuity, monocular defocus curves, decentration and tilt, wavefront aberrometry, VF-7 questionnaire and a halo and glare simulator. 50 eyes of 25 subjects were enroled. The trifocal IOL performed better at monocular DCNVA (p < 0.01) and at defocus levels of -1.5D to -4.0D (p < 0.01), the monofocal EDOF IOL was better at -0.5D (p = 0.013). No differences in monocular BCDVA, DCIVA, contrast acuity, decentration or tilt were observed (p > 0.05). Wavefront analysis revealed lower HOAs in the trifocal group at 5 mm (p < 0.01) and no difference (p = 0.107) at 3 mm pupil aperture. The monofocal EDOF IOL displayed increased negative SA at 5 mm (p < 0.01) and 3 mm (p < 0.01) pupil diameter. Low values of optical phenomena and satisfying results of the VF-7 questionnaire were obtained. Excellent visual performance and low rates of optical phenomena were achieved after mix-and-match implantation of the monofocal EDOF Isopure IOL and the trifocal FineVision HP IOL. Trifocal IOL implantation in the non-dominant eye may decrease optical disturbing phenomena. Similar results were observed for monocular distance, intermediate and contrast VA. The trifocal IOL provided better monocular near VA. Decentration and tilt and HOAs were low.

Optical-Quality Assessment of a Miniaturized Intraocular Telescope.

Age-related macular degeneration (AMD) causes severe vision impairments, including blindness. An option to improve vision in AMD patients is through intraocular lenses and optics. Among others, implantable miniaturized telescopes, which direct light to healthy lateral regions of the retina, can be highly effective in improving vision in AMD patients. Yet, the quality of the restored vision might be sensitive to the optical transmission and aberrations of the telescope. To shed light on these points, we studied the in vitro optical performance of an implantable miniaturized telescope, namely, the SING IMT™ (Samsara Vision Ltd., Far Hills, NJ, USA) designed to improve vision in patients affected by late-stage AMD. Specifically, we measured the optical transmission in the spectral range 350-750 nm of the implantable telescope with a fiber-optic spectrometer. Wavefront aberrations were studied by measuring the wavefront of a laser beam after passing through the telescope and expanding the measured wavefront into a Zernike polynomial basis. Wavefront concavity indicated that the SING IMT™ behaves as a diverging lens with a focal length of -111 mm. The device exhibited even optical transmission in the whole visible spectrum and effective curvature suitable for retinal images magnification with negligible geometrical aberrations. Optical spectrometry and in vitro wavefront analysis provide evidence supporting the feasibility of miniaturized telescopes as high-quality optical elements and a favorable option for AMD visual impairment treatments.

Assessment of contrast sensitivity and wavefront analysis after aspheric and spherical intraocular lens implantation.

Assessment of contrast sensitivity and wavefront analysis after aspheric and spherical intraocular lens implantation.