The study focuses on a semi-submersible wind-wave integrated power-generation platform, which consists of an OO-Star semi-submersible platform equipped with a DTU 10 MW wind turbine and a set of wave energy converters. A hydrodynamic model was established using ANSYS-AQWA (2023 R1), and by incorporating upper wind loads and utilizing the open-source program F2A, a fully coupled time-domain model of the integrated power-generation platform was constructed. The primary objective is to explore the interaction mechanisms between the upper wind turbine and the lower wave energy devices under the combined effects of irregular waves and turbulent wind through a series of operational conditions. Additionally, the safety of the mooring system was assessed. The results indicate that, compared to the wave period, the power generation of the lower wave energy devices is more significantly affected by wave height. Overall, the integrated power-generation platform demonstrates optimal performance under the third operational condition. In survival conditions, the introduction of oscillating buoys can improve the motion responses of the platform in terms of sway, roll, pitch, and yaw to a certain extent, but it also increases the surge and heave motion responses and the associated mooring loads. The mooring system can ensure the safety of the integrated power-generation platform under extreme sea conditions.