Drylands in northwest China have limited water resources, which negatively impacts economic development, ecological security, and the United Nations Sustainable Development Goals. However, few studies have examined water supply and demand under multiple future spatial patterns of land use, particularly under sustainable development scenarios. Further research is therefore needed to determine how affect water output services under various land use patterns. We used the GMOP-PLUS (Gray Multi-objective Optimization-Patch-generating Land Use Simulation) and the InVEST (Integrated Valuation of Ecosystem Services and Tradeoffs) models to investigate future land use programs and the current and future trends in water yield services supply and demand in the typical dryland region of Xinjiang, China. The GMOP-PLUS model was used to project the spatial patterns of land use/land cover (LULC) change in Xinjiang in 2025 and 2030 under programs of business-as-usual, rapid economic development, ecological land protection and sustainable development. We then used the InVEST model to project the spatiotemporal evolution of water yield services supply and demand under the four different scenarios. Our results show that Our results show that water production in Xinjiang decreases to 911.30 × 108 m3 in 2020–2030 under the business-as-usual scenario, with an expansion in arable land and a reduction in forested land being the main causes of this decrease. The decline in water production under the ecological land protection scenario is 913.88 × 108 m3. The retention effect of vegetation slows the decline in water production, but the ecological land protection scenario is not effective in controlling the reduction in arable land. The rapid economic development scenario produces a significant increase in water yield of 915.09 × 108 m3, mainly due to an increase in the area of impervious surfaces caused by the expansion of built-up land; however, the rapid economic development scenario leads to a decreasing trend in ecological land. The sustainable development scenario produces 914.15 × 108 m3 of water. The sustainable development scenario increases water production while balancing the development of Constructed and the protection of ecological land, and the arable land also shows a slow growth trend. Between 2025 and 2030, the water security index fluctuates between –0.0225 and –0.0400, with a continued future deficit in water supply and demand in Xinjiang and a high degree of spatial heterogeneity. Programs for advancing sustainable development narrow the supply–demand gap for services that produce water.