The basin of the Ili River and its tributaries within Kazakhstan is limited from the south with Trans-Ili Alatau and Kungei Alatau, from the west with north-eastern spurs of the Chu-Iliysk mountains (Aitau), from the north with the Balkash lake (delta of the Ili River) and the valley of the Karatal river, from the north-east with the Zhungar Alatau, but from the east and the south-eat with the Ketmen ridge and the Terskey Alatau. We studied pollution of the Ili River run-off from the border with the People’s Republic of China – (river station of the Dubun’ village) to the Balhash lake – river station of the Ushzharma village. For this purpose we processed data on river stations of the Dubun’ pier, 164 km higher than Kapshagai HPP (hydroelectric power station), Kapshagai, Ushzharma. Available data on pollution of the Republican State Enterprise “Kazgidromet” rivers run-off is mainly presented on copper and iron. The quality monitoring network for land surface waters include gauging stations of the National Hydrometeorological Service. The main criteria for water quality according to hydrochemical parameters are values of maximum permissible concentration (MPC) of pollutants for waters bodies of fishery, potable and household water use. The level of land surface waters pollution is estimated according to a value of the complex water pollution index (WPI), which is used to compare and identify dynamics of change in water quality. The Ili River is the main waterway of the Balhash lake basin. It originates in the Muzart glaciers in the Central Tanirtau (Kazakhstan) with the Tekes river source. Then it flows on the territory of China, where it merges with the rivers Kunes and Kash, at the 250th km from the confluence point it enter the Republic of Kazakhstan again and at the 1001st km it runs into the Balhash lake. The total length of the river is 1439 km, within Kazakhstan – 815 km. The total area of the Ili River basin is – 140 thousand sq. km (approximately 75% of the catchment area of the Balhash lake, from which 44400 sq. km – on the territory of the Republic of Kazakhstan. The river flow forming part of the basin is situated in China, where the hydrographical network is sufficiently developed (from 0.6 to 3 km/sq. km). 30% of the water resources of the Ili River are formed in Kazakhstan. Besides the Sharyn and Shelek rivers, a series of mountain rivers join the Ili River in the left-bank part of the basin: Turgen’, Issyk, Talgar, Kaskelen with the tributaries of Small and Big Almatinka, Kurty, which form a flow on the northern slope of the Trans-Ili Alatau. In the right bank part the largest tributaries of the Ili River are Horgos, Usek and Borohudzir, flowing down from the