The last decade rapid development of catalytic reactions in organic solvent -water bifase systems, especially enantioselective processes, focused the attention of chemists on the synthetic roads to the chiral water-soluble phosphine ligands The reaction of bis(oxymethy1)phenyl-phosphine, paraform and (R)- or (S) α aminoacides open a road to a numerous chiral heterocyclic phosphines and their transition metal complexes with high water solubility.