The formation water evaporates seriously because of the drastic pressure change in near-well zone during the exploitation of deep high temperature gas reservoir. The crystallization salt precipitates in the formation when the salt concentration of formation water increases to solubility limit, which results in the decrease of reservoir porosity and permeability. At present, there is a lack of the prediction and process design of salting out in deep high temperature gas reservoirs. The evaporation salting out experiment of formation water was carried out firstly in this paper, and the volume model of salting out zone was established based on the water content model of natural gas, the porosity and permeability model of reservoir, and the kinetics model of salting out. And the characterization method of predicting porosity and permeability of high temperature gas reservoir after salting out was established by fitting and modifying the model finally, which could provide a theoretical basis for salting out plugging formation in depressurization production of gas reservoirs and laid a foundation for the efficient development of deep high temperature gas reservoirs.