Building ecological civilization has become a consensus of the whole society. However, problems caused by water pollution and shortage of water resources cause huge economic losses every year. Over the years, the issue of water pollution in the Weihe River has attracted widespread attention from all walks of life. The premise of controlling the water pollution of the Weihe River is to find out the sources of pollution and the amount of pollutants discharged. Therefore, this study takes the Shaanxi section of the Weihe River Basin as the research section, and conducts a basic survey of the water pollution status of the main stream and tributaries of the Weihe River, and analyzes the sources, types and discharges of major wastewater pollutants, so as to provide the basis and basic data for the comprehensive management of the Weihe River Basin.