Climate change is having short- and long-term impacts on surface and groundwater in the northern part of the African continent. This has led to a wide range of consequences that have added pressure on the groundwater systems in this part of the world. Among such pressures, we can cite the mal-distribution and the irregularity of precipitation and ice, flooding, evaporitic sediments input by the drainage net, water degradation, mud stagnation in dams, dead tranche, drought, decreasing of the natural recharge and increasing of the groundwater abstraction, conflict between trans-boundary waters, desertification, imbalance between the regions, migration, revolution, socio-economic imbalance, etc. Actually, water-monitoring networks indicate noticeable hydrogeologic variations and a rise of the groundwater salinity. It was confirmed by the geochemical analysis of water resources that showed scattered data between the northern part characterized by low mineralized groundwater (TDS ranging 0.4–3 g/l) and the southern area where the salinity ranges from 2.5 to 90 g/l. The obtained values are far above the permissible limits for both human consumption, agricultural and tourist activities. These effects, when compounded, are anticipated to worsen the situation and to constitute veritable threats for social and economic development in these regions of North Africa (Morocco, Algeria, Tunisia, Libya, Egypt, etc.). The potential solutions consist of taking urgent to utilize the intelligent technology (bio and nano-technology), policies relevant policies to manage water resources, and the engagement of private, civil, and international sectors if a major crisis is to be averted (collective effort).