BackgroundCogeneration power plants traditionally rely on fossil fuels to produce stable power and heat. However, increasing energy demand and population growth have intensified the emission of biological pollutants due to fossil fuel use. The Global Alliance on Health and Pollution advocates for integrating renewable energy sources to mitigate these issues. ObjectivesThis study aims to evaluate the integration of a solar-biomass polygeneration system with a hybrid solar-waste-fossil fuel cogeneration system. The goal is to analyze the system from technical, economic, and environmental perspectives, focusing on optimizing energy demand and minimizing environmental impact. MethodsTo assess energy demand and supply, the R-curve methodology was applied to the hybrid cogeneration system, with a specific focus on solar and biomass renewable energies. Various scenarios were analyzed, including total annual costs, pollutant emissions, water footprint, and overall environmental impact based on life cycle assessment. The study examined and compared the performance of three types of biomass waste (Municipal solid waste, mixed paper waste, and date palm waste). Multi-objective optimization was performed using artificial intelligence and machine learning techniques, employing four meta-heuristic algorithms. The conditions generated by each algorithm were analyzed and compared. ResultsMunicipal solid waste, being the most readily available fuel, provided the most favorable economic conditions for the system. Environmentally, municipal solid waste ranked in the middle compared to other fuels. Among the optimization algorithms, the Salps swarm algorithm proved to be the most efficient in terms of calculation time and system efficiency improvements. The optimization improved net power generation by 5.25 %, overall energy efficiency by 16.27 %, total cost rate by 10.19 %, and total environmental impact rate by 14.02 %. ConclusionThe integrated system's performance was analyzed across different climatic change throughout the year. The multi-objective Salps swarm algorithm optimization demonstrated significant benefits in enhancing system efficiency and reducing costs and environmental impacts.