Climate changes tend to intensify water scarcity in arid and semi-arid regions, making water management in these areas more challenging, directly influencing hydrological dynamics, causing impacts on ecosystems and society. The Terra Nova River basin is crucial for the water security of the semi-arid region of Pernambuco, especially after the construction of the São Francisco River Integration Project (PISF), which saw the construction of six reservoirs to supply water for human consumption, agricultural, and industrial activities. Therefore, this study aims to analyzes the impacts of climate changes on water quality in the Terra Nova River basin in Pernambuco, using long-term data from the Hydrological Response Unit System for Pernambuco (SUPer). The ARIMA (Autoregressive Integrated Moving Averages) model is employed to predict water quality parameters in climate change scenarios, using data from the Intergovernmental Panel on Climate Change (IPCC) and the Oswaldo Cruz Foundation (Fiocruz). The variables include air temperature, precipitation, dissolved oxygen, nitrogen, and phosphorus. Simulated scenarios were compared with CONAMA No. 357/2005 limits, revealing potential decreases in dissolved oxygen and phosphorus concentrations, alongside an increase in nitrogen concentrations. Irregular rainfall rates, high air temperatures, and evapotranspiration, combined with conflicts by water resources, may exacerbate water access issues in the semi-arid region, worsening the water crisis and threatening water security.