The Gongshui River basin exhibits one of the most serious soil erosion areas in southern China, and has always been the key control area of national soil and water conservation programs. This study used daily precipitation, streamflow, and sediment concentration data collected from 1957 to 2015 from the main hydrological stations of the Gongshui River to investigate streamflow and sediment discharge variations and their responses to precipitation and human activities. The Mann-Kendall and Pettitt’s test were used for trend and change-point detection. The double mass curve (DMC) method was employed to quantify the effects of precipitation change and human activities on hydrological regime shifts. The results showed insignificant trends of both annual precipitation and streamflow for all stations, while the sediment discharge of most stations exhibited significant decreasing trends. Change-point analyses revealed that all hydrologic stations except Mazhou had transition years. The estimation via DMC indicated that after the change point years, there was a rapid reduction in sediment discharge at Hanlinqiao, Fengkeng, Julongtan, Xiashan, and Chawu stations, but not at Mazhou, Ruijin, and Yangxinjian stations. Human activity provided a significantly greater contribution to sediment discharge than precipitation. The evidence clearly indicates that the degree and extension of conservation or destruction measures and the construction of large- and medium-sized reservoirs were the major factors significantly decreasing or increasing annual sediment discharge of the Gongshui River. This work could serve as the basis for decision making regarding river basin water resources management to estimate the effects of anthropogenic impacts on water and sediment discharge variations during the last few decades, thereby guiding adaptation and protection of the water resources of the Gongshui River flowing into the Poyang Lake.