The novel COVID-19 pandemic has significantly impacted all facets of society globally. Often overlooked is the potential contamination of the waste disposed by individuals diagnosed with the virus. The proliferation of contaminated waste is expected to increase as cases increase. The pandemic has caused a surge in waste material stemming from the widespread use of disposable personal protective equipment at the household level. In the developing countries where waste management measures are relatively inadequate, the vulnerability of COVID-19 contraction from contaminated waste is high. This study intended to unravel the susceptibility of communities in the developing countries of Guyana and Nigeria to the potential spread of the virus through waste. The study explored the possibility of cross-contamination between residents and landfill scavengers, the community perception on the effectiveness of their solid waste practices, the notable changes in waste collection and waste disposal patterns, and also, the potential knowledge / policy gaps that exist. An online survey was administered within all the districts of the two countries and the qualitative assessment was conducted demonstrating the proportional trends in the responses of the participants. Findings showed that the communities were relatively perceptive about the issue of waste disposal and the potential contamination of COVID-19. The communities readily recognized the inefficiencies of the waste management systems and the need for policy intervention. Tackling the issue of COVID-19 and waste management in the developing countries of Guyana and Nigeria requires policies that are holistic and participatory involving stakeholder at all levels.