Global warming, induced by the effects of Greenhouse Gases (GHGs), is a major concern in the context of the global ecosystem. The Intergovernmental Panel on Climate Change (IPCC) has issued a serious warning that without serious handling of GHG emissions, the earth's temperature has the potential to increase drastically by up to 6.4°C. In facing this challenge, Life Cycle Assessment (LCA), as an analytical method, becomes an important instrument for evaluating the impact of a product or process throughout its life cycle. This research has a special focus on evaluating strategies for transporting waste from the Panakkukang sub-district to the Tamangapa final disposal site (TPA) in Makassar city. By comparing existing waste transportation routes and alternative scenarios, this research aims to identify transportation routes that have the smallest contribution to the Global Warming Potential (GWP). It is hoped that the results of this research can provide valuable guidance for the development of a sustainable waste transportation system in the city. Thus, this research not only has the potential to increase awareness of environmental impacts but can also make a significant contribution to efforts to create a friendly and sustainable environment in an increasingly urgent era of global warming.