For analysis of influence factors on heavy metal release from different weathering mine waste rock in Fu Xin mine area under the effect of rain water leaching, the materials which come from mine waste rock pile nearby Xin Qiu mine is collected and then process a serial leaching experiments. The initial PH value of leaching solution and experiment temperature have been selected to as influencing factors according to rainfall and weather condition of Fuxin mining area. The concentration of five heavy metal elements: Cd, Cr, Cu, Mn and Pb are tested in leaching solutions. The results show that the constituent characteristics of stratum rock is a major factor influenced on leaching solutions and heavy metal release. The weakly acidic leaching solution becomes to weakly alkaline after leaching the waste rock. The quantities of different heavy metal release represent disparate rules, influenced by distinct weathering degree. Concentrations of Cd and Cr increase with the leaching solution's pH value variation while Cu, Mn and Pb decreased. Higher temperature leads more heavy metal elements release from the waste rock.