Abstract Unsanitary conditions in domiciles often stem from complex social and health-related issues, involving the elderly and/or individuals with mental health problems. These situations typically lead to a decreased quality of life for those involved, directly and indirectly, and may pose a risk to public health depending on their magnitude. In Cascais municipality, identified cases of unsanitary conditions undergo a multidisciplinary analysis. It has been established a Local Technical Group for Domiciliary Unsanitary Situations, comprising various institutions such as local authorities, law enforcement agencies, civil protection, health and social security ministries, and the animal rescue center. This group operates under a One Health approach, encompassing human health, environmental health, and animal health. Interventions are determined by the working group, with the aim of promoting health and enhancing citizens’ quality of life. Cases of unsanitary conditions reported are subsequently discussed within the technical group, which has regular meetings, and may organize joint assessment visits and appropriate actions. This social and environmental initiative responds to the growing need to address unsanitary and cluttered living conditions, which significantly impact individuals’ physical, emotional, and social well-being. The objective is to restore housing conditions in homes by removing waste and unnecessary items, contributing to general individual well-being. While international studies suggest a correlation between unsanitary conditions and hoarding disorder, it’s crucial to differentiate between distinct and independent situations caused by various physical, psychological, and cognitive processes. The establishment of a Local Technical Group for Domiciliary Unsanitary Situations exemplifies a proactive approach to addressing complex health and social challenges, emphasizing collaboration, and holistic intervention strategies, always with a One Health approach. Key messages • Addressing unsanitary conditions is crucial for safeguarding public health, impacting physical, emotional, and social well-being. • The establishment of a Local Technical Group for Domiciliary Unsanitary Situations, under a One Health framework, reflects a collaborative approach to addressing complex health and social challenges.