The world due to increased urbanization and globalization is facing major environmental challenges. Anthropogenic emissions of Greenhouse gases (GHG) like carbon dioxide and methane are on the rise and unsustainable which needs to be regulated. Open dumping of Municipal Solid Waste (MSW) contributes to generation of greenhouse gases like carbon dioxide and methane. This is because large fractions of the waste open dumped are organic in nature which undergoes anaerobic decomposition leading to generation of GHGs. In particular, methane has a high potential for energy generation and if utilized could be highly beneficial. The present study assesses the generation of landfill gases, primarily methane generation potential from MSW generated in Kanpur city using LandGEM 3.02 version model developed by USEPA for the period 2015–2030. It was observed from the study that the cumulative LFGs generation, methane emission and energy recovery potential estimated as 233.44 × 106 m3, 116 × 106 m3 and 858.14 × 106 MJ respectively. Uncertainty analysis carried out showed that variation in methane emissions maybe attributed to input parameters of k and Lo of the LandGEM model. The study shows that there exists high potential to control the greenhouse gas emissions by utilizing the methane generated for energy production.