In the present work, the fabrication of a facile, cost-effective, uniform, and reusable platform for the detection of analytes using surface-enhanced Raman scattering is discussed. An interconnected metal network structure made using gold (generally named as Nanoporous Gold) is fabricated via a time-varying chemical dealloying method. Using rhodamine 6G as a Raman reporter molecule, the surface-enhanced Raman scattering effectiveness of the dealloyed samples is studied. The 30- and 45-min etched samples show the highest enhancement induced by the large number of nano-ligaments and nano-gaps between the adjacent ligaments. The proposed substrates exhibit a five-fold SERS enhancement with an excellent uniformity over the sample surface with relative standard deviation value of less than ∼20%. Moreover, through an ethanol wash, the nanoporous gold substrate can be easily reused at least four times with a reproducible SERS signal with the same SERS enhancement.