Background: Policies that improve the availability of safe drinking water, good hygiene practices and adequate sanitation conditions are considered crucial ingredients to sustain and improve the health of all populations. To attain the United Nations Sustainable Development Goals require concerted efforts globally to improve or health related morbidity outcomes as a result of poor water sources, sanitation and unhygienic conditions.Aim: The study assessed water, sanitation and hygiene related practices among household residents in Hohoe Municipality, Ghana with the aim of mapping out targeted policies required to improve urban population health in Ghana.Setting: Hohoe Municipality, Ghana.Method: A descriptive cross-sectional design was used to collect data among 403 household residents in Hohoe Municipality, Ghana. Participants were selected using multistage sampling technique. Data was collected using self-administered questionnaire, entered, cleaned and analyzed in STATA version 13.1.Findings: About 16.4% of the participants practiced open defecation. Overall, 58% of the 403 household residents had adequate hygiene practice levels. Percentages of participants that had improved, unimproved and piped drinking water sources were 67%, 14% and 19% respectively.Conclusion: Participants generally had a fairly adequate hygiene practice level and access to improved drinking water source. While almost half of the participants did not own or shared a private toilet facility. Our findings underscore the need for WASH interventions including policies to improve upon WASH practices among the households in Hohoe Municipality.