Transport and macroeconomic development are closely linked. Under the comprehensive management system for China’s rail, road, water, and air transport, there is an urgent need for a comprehensive, timely, and accurate index that reflects the relationship between transport and the macroeconomy, to help the government analyze the current situation of transport, judge the macroeconomic and sustainable transport trends, and make scientific decisions, so as to achieve the carbon emission peak and carbon neutrality goals. This paper innovatively proposed the Transport Development Index (TDI), a new evaluation system with 38 indicators, covering the infrastructure, development scale, efficiency, sustainability, and safety and profitability of the four modes of transport: road, rail, water, and air. The analytic hierarchy process and the entropy weight method were used to determine the weights for the indicators. Yunnan was selected as a case study to calculate the TDI values for 2016 to 2021 and analyze the transport service performance for each year. The study results show that the TDI can be used for analyzing the regional transport services and economic operation status, proving the positive effect of transport development on the macroeconomy or warning of possible risks, and facilitating scientific decision making for sustainable transport development.