When a single intravenous load of hypertonic saline was administered to shamoperated ducks the extrarenal excretion of electrolytes by the nasal glands was the same as that of the intact bird. The plasma corticosterone concentrations of chronically adenohypophysectomized ducks was reduced to less than 10% of that in the sham-operated birds, and the extrarenal excretion of water and electrolytes was decreased to approximately 5% of normal. Treatment of the adenohypophysectomized birds with ACTH restored the plasma corticosterone concentrations and the extrarenal response to normal. The intravenous administration of glucose to the adenohypophysectomized birds during the waning phase of extrarenal excretion failed to either prolong or increase the rate of water and electrolyte excretion. Although the regulation of nasal gland function may be indirectly facilitated by the gluconeogenic action of the adrenal steroids, a direct action of these hormones on the nasal gland tissue may be essential for normal extrarenal function.