Shear Stress Research Articles

Mechanical Properties of Inflamed Appendix Tissues

Background/Objectives: Histopathological examination enables visualization of morphological changes in cells and tissues. In recent years, there has been increasing interest in assessing the mechanical properties of tissues that cannot be determined by standard histopathological examinations. Mechanobiology is crucial in human physiology and holds promise for uncovering new diagnostic markers for disease processes such as carcinogenesis and inflammation. In this study, we concentrated on measuring the mechanical properties of appendix biopsy specimens to identify potential mechanomarkers of inflammation. Appendix tissues provided the opportunity to measure mechanical properties both with an atomic force microscope and a shear rheometer. Methods: The atomic force microscope AFM—NanoWizard 4 BioScience JPK/Bruker was used for the evaluation of the elastic modulus (i.e., Young’s modulus) of appendix tissues. Young’s modulus was derived from the Hertz-Sneddon model applied to force-indentation curves. The rheological properties of macroscopic samples were measured on a parallel-plate, strain-controlled shear rheometer Anton Paar MCR302. Results: The data collected suggest that elasticity, expressed as Young’s modulus and the storage modulus, could be considered a marker indicating appendix tissue inflammation. Young’s modulus of inflamed appendix tissues was found to be significantly lower than that of healthy ones, with an average reduction of 67%. Furthermore, it was observed that inflamed appendix tissues, in comparison to healthy ones, respond differently under varying axial and shear stresses, enabling their identification. Conclusions: Our findings suggest that the specific mechanical properties of inflamed vermiform appendices could serve as novel mechanomarkers for the early detection and monitoring of appendicitis.

Rheology of Cellulosic Microfiber Suspensions Under Oscillatory and Rotational Shear for Biocomposite Applications

This study investigates the rheological behavior of cellulose microfiber suspensions derived from kahili ginger stems (Hedychium gardnerianum), an invasive species, in two adhesive matrices: a commercial water-based adhesive (Coplaseal®) and a casein-based adhesive made from non-food-grade milk, referred to as K and S samples, respectively. Rheological analyses were performed using oscillatory and rotational shear tests conducted at 25 °C, 50 °C, and 75 °C to assess the materials’ viscoelastic properties more comprehensively. Oscillatory tests across a frequency range of 1–100 rad/s assessed the storage modulus (G′) and loss modulus (G″), while rotational shear tests evaluated apparent viscosity and shear stress across shear rates from 0.1 to 1000 s−1. Fiber-free samples consistently showed lower moduli than fiber-containing samples at all frequencies. The incorporation of fibers increased the dynamic moduli in both K and S samples, with a quasi-plateau observed at lower frequencies, suggesting solid-like behavior. This trend was consistent in all tested temperatures. As frequencies increased, the fiber network was disrupted, transitioning the samples to fluid-like behavior, with a marked increase in G′ and G″. This transition was more pronounced in K samples, especially above 10 rad/s at 25 °C and 50 °C, but less evident at 75 °C. This shift from solid-like to fluid-like behavior reflects the transition from percolation effects at low frequencies to matrix-dominated responses at high frequencies. In contrast, S samples displayed a wider frequency range for the quasi-plateau, with less pronounced moduli changes at higher frequencies. At 75 °C, the moduli of fiber-containing and fiber-free S samples nearly converged at higher frequencies, indicating similar effects of the fiber and matrix components. Both fiber-reinforced and non-reinforced suspensions exhibited pseudoplastic (shear-thinning) behavior. Fiber-containing samples exhibited higher initial viscosity, with K samples displaying greater differences between fiber-reinforced and non-reinforced systems compared to S samples, where the gap was narrower. Interestingly, S samples exhibited overall higher viscosity than K samples, implying a reduced influence of fibers on the viscosity in the S matrix. This preliminary study highlights the complex interactions between cellulosic fiber networks, adhesive matrices, and rheological conditions. The findings provide a foundation for optimizing the development of sustainable biocomposites, particularly in applications requiring precise tuning of rheological properties.

Shale Fracture Static Stability Evaluation Method Based on 3D Discrete Fracture Model: A Case Study on the Luzhou Area in Southern Sichuan Basin, SW China

Abstract The stress interference in deep shale may lead to shale fracturing and instability and consequently results in engineering risks such as casing deformation in horizontal wells. Therefore, in the early stages of shale gas exploration and development, it is of great significance to evaluate the stability of shale fractures in advance. The stability evaluation of shale reservoir faults can be mainly divided into two categories at present: quantitative evaluation of single faults and qualitative evaluation of wide-range faults. The quantitative evaluation of single faults primarily relies on numerical simulation techniques, while the qualitative evaluation of wide-range faults primarily employs geophysical methods. Both methods are difficult to meet the needs of shale gas exploration and development. The shale fracture stability evaluation method based on 3D discrete fracture model which is developed in this article can quantitatively evaluate the static stability of wide-range shale fractures in the early stage of exploration and development. In this article, seismic geometric attributes were calculated, and fracture seismic facies was established by means of the Bayesian probabilistic cluster analysis method. Then, 3D discrete fracture modeling under the constraint of fracture seismic facies was performed to establish a discrete fracture model. Finally, according to the Mohr–Coulomb criterion, the shear stress and effective normal stress of discrete fracture were calculated by using the formation pressure data in other exploration and development results and the regional in situ stress obtained through seismic prestack inversion. And thus, the stability evaluation of the fractures in shale reservoirs was eventually completed. In addition, this method was verified by using the casing deformation points in some actual shale-gas horizontal wells, the actual small fault points, and microseismic data. It indicates that the method has higher accuracy and is better applicable to the early shale gas exploration and development.

Comparison and identification of human coronary plaques with/without erosion using patient-specific optical coherence tomography-based fluid-structure interaction models: a pilot study.

Plaque erosion (PE) with secondary thrombosis is one of the key mechanisms of acute coronary syndrome (ACS) which often leads to drastic cardiovascular events. Identification and prediction of PE are of fundamental significance for disease diagnosis, prevention and treatment. In vivo optical coherence tomography (OCT) data of eight eroded plaques and eight non-eroded plaques were acquired to construct three-dimensional fluid-structure interaction models and obtain plaque biomechanical conditions for investigation. Plaque stenosis severity, plaque burden, plaque wall stress (PWS) and strain (PWSn), flow shear stress (FSS), and ΔFSS (FSS variation in time) were extracted for comparison and prediction. A logistic regression model was used to predict plaque erosion. Our results indicated that the combination of mean PWS and mean ΔFSS gave best prediction (AUC = 0.866, 90% confidence interval (0.717, 1.0)). The best single predictor was max ΔFSS (AUC = 0.819, 90% confidence interval (0.624, 1.0)). The average of maximum FSS values from eroded plaques was 76% higher than that from the non-eroded plaques (127.96 vs. 72.69 dyn/cm2) while the average of mean FSS from erosion sites of the eight eroded plaques was 48.6% higher than that from sites without erosion (71.52 vs. 48.11 dyn/cm2). The average of mean PWS from plaques with erosion was 22.83% lower than that for plaques without erosion (83.2kPa vs. 107.8kPa). This pilot study suggested that combining plaque stress, strain and flow shear stress could help better identify patients with potential plaque erosion, enabling possible early intervention therapy. Further studies are needed to validate our findings.

Abstract 4117345: Predicting Downstream Aneurysmal Degeneration Following Type A Dissection Repair With Computational Fluid Dynamics

Introduction: Acute type A aortic dissection (ATAAD) is typically treated by replacement of the ascending aorta (+/- root) and proximal arch. However, 70-85% of patients have residual distal dissection post-repair, and 20-40% require late reoperation for aneurysmal degeneration of the distal aorta (ADDA). Since an individual patient’s risk of ADDA cannot be accurately predicted, current guidelines recommend lifelong aortic surveillance imaging for all patients. Hypothesis: Computational fluid dynamics (CFD) simulations of aortic hemodynamics post-repair can accurately identify patients at late risk of ADDA. Methods: We performed CFD simulations of 50 patients following hemi-arch replacement for ATAAD. Patient-specific 3D models were generated from the aortic root to iliac bifurcation (including arch branches) from postoperative 0.6mm contrast-enhanced CT angiograms taken <1 year after index repair (Figure). Exclusion criteria were known heritable thoracic aortic disease and absence of residual dissection. The primary outcome was ADDA, defined as late growth of the distal arch/descending thoracic aorta (DTA) to a diameter ≥5.5cm. Hemodynamic simulations were run for 6 cardiac cycles on a high-performance computing cluster using HARVEY, a CFD solver implementing the lattice Boltzmann method. The primary hemodynamic metric was time-averaged wall shear stress (TAWSS) ratio between the false and true lumens. Results: ADDA developed in 22 patients (44%) at a mean of 3.2 years postoperatively. There were no significant clinical differences between those with and without ADDA (Table). The development of late aneurysm growth was significantly associated with a higher TAWSS ratio in the proximal DTA ( p <0.05, Figure). Conclusion: ADDA following hemi-arch repair for ATAAD is associated with significantly higher false lumen TAWSS as early as the first surveillance scan. CFD simulations may help clinicians risk-stratify patients years before they meet reoperation criteria.

Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway.

Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and extracellular matrix (ECM) stability. We exposed SW1353 chondrocytes to low FSS (1.8 dyn/cm2, 60min) and found that it led to a significant downregulation of microRNA-143-3p (miR-143-3p), which was associated with increased chondrocyte proliferation and ECM secretion, including type II collagen (COL2A1) and aggrecan. Further investigation revealed that miR-143-3p directly targeted ERK5, a key component of the ERK5/KLF4 signaling pathway. Overexpression of miR-143-3p suppressed ERK5/KLF4 pathway activation, resulting in reduced chondrocyte proliferation and ECM production. Our findings demonstrate that low FSS promotes chondrocyte proliferation and ECM secretion by downregulating miR-143-3p, leading to the activation of the ERK5/KLF4 signaling pathway. This study reveals a novel mechanism by which FSS regulates chondrocyte behavior and ECM secretion, highlighting the potential of FSS as a therapeutic target for cartilage-related diseases.

Abstract 4119062: A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling

Background: Vascular remodeling to match arterial diameter to tissue metabolic requirements commonly fails in ischemic disease. Endothelial cell (EC) sensing of elevated fluid shear stress (FSS) from blood flow induces vessel outward remodeling to restore physiological FSS, but mechanisms are poorly understood. The Smad1/5 pathway, which is maximally activated at physiological FSS and suppressed at higher flow, opposes activation of Akt, suggesting that inhibiting Smad1/5 may be required for outward remodeling. Methods: In vitro flow studies used ECs in a parallel plate flow chamber. In vivo mouse studies used a carotid-jugular fistula model to induce high flow outward remodeling in the carotid artery, and femoral artery ligation to examine recovery from ischemia and arteriogenesis in the hindlimb. Results: Suppression of Smad1/5 at high FSS is mediated KLF2-dependent induction of the BMP pathway inhibitor BMPER, which suppresses Smad1/5 and de-inhibits Akt. In a mouse arteriovenous fistula (AVF) model, high FSS induces arterial outward remodeling coincident with elevated BMPER expression and Smad1/5 inactivation. Endothelial BMPER deletion impaired blood flow recovery and vascular remodeling in the AVF and a hindlimb ischemia (HLI) model, with the latter reversed by BMP9/10 blocking antibodies (bAbs). In both STZ-induced type 1 and HFD-induced type 2 diabetic mice that show poor recovery from HLI, BMP9/10 bAbs improved outcomes. Conclusions: Suppression of Smad1/5 through a KLF2-BMPER pathway is required for high FSS-mediated outward remodeling. Mimicking this pathway with BMP9/10 antibodies improves vascular remodeling in diabetic mice, suggesting a potential new therapeutic approach for ischemic disease.

Repositioning of aripiprazole, an anti‑psychotic drug, to sensitize the chemotherapy of pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited therapeutic options. Cisplatin is a primary chemotherapeutic agent utilized in combination with other drugs or radiotherapy for PDAC treatment. However, the severe side effects of cisplatin often necessitate discontinuation of therapy and drug resistance in tumor cells poses significant clinical challenges. Therefore, the development of effective therapeutic strategies is imperative. The present study investigated whether repositioning of the antipsychotic drug aripiprazole could sensitize the anticancer activity of cisplatin in pancreatic cancer at doses calculated by the combination index. The findings indicated that aripiprazole combined with cisplatin to suppress pancreatic cancer cell growth. Notably, the combination notably increased the expression of apoptosis markers, including cleaved caspase‑3, compared with cisplatin alone. Additionally, this combination effectively decreased XIAP and MCL‑1 expression via mitochondrial membrane potential change as revealed by JC‑1 assay, thereby inducing apoptosis. Furthermore, in fluid shear stress assay, the combination of aripiprazole and cisplatin notably inhibited cell adhesion and tumor spheroid formation. Mechanistically, phospho‑kinase array profiles showed that the enhanced anticancer efficacy of the combination treatment could be attributed to the inhibition of STAT3 signaling, which led to a significant reduction in tumor growth in a pancreatic cancer animal model. The results showed that the repositioning of aripiprazole inhibits cancer cell growth by blocking the STAT3 signaling pathway and effectively enhancing cisplatin‑induced apoptosis, thereby suggesting that the combination of aripiprazole and cisplatin may be a potent chemotherapeutic strategy for the treatment of pancreatic cancer.

Abstract 4145829: Fatty Acid Binding Protein 4 as Potential Indicator for Gestational Diabetes Mellitus-Induced Fetal Endothelial Dysfunction

Introduction/Background: Gestational diabetes mellitus (GDM) is the most common complication during pregnancy. GDM is leading to an elevated risk for the development of cardiovascular diseases both in the mother and the child in later life. Previous studies have identified fatty acid-binding protein 4 (FABP4) as a prime candidate involved in the pathophysiology of GDM. Indeed, women with GDM exhibit elevated blood levels of FABP4, suggesting its potential role as a biomarker for endothelial dysfunction and cardiovascular risk assessment in GDM. Research Question/Hypothesis: Does FABP4 affect the function of human endothelial cells from patients with GDM? Goals/Aim: Our aim is a better understanding of the role of FABP4 in fetal endothelial dysfunction of patients with GDM and the development of potential therapeutic strategies. Methods/Approach: Primary human umbilical vein endothelial cells (HUVECs) were isolated from umbilical cords obtained from normoglycemic and GDM pregnancies. Total mRNA from HUVECs was used for bulk RNA sequencing to compare gene expression pattern. HUVECs were subjected to functional analyses assessing proliferation, migration, NO and insulin signaling. Finally, human endothelial cells were exposed to high laminar flow (30 dyn/cm 2 ) or simvastatin (10 nM) treatment to investigate their impact on FABP4 expression and endothelial function. Results/Data: Bulk RNA sequencing data analysis revealed FABP4 as a gene overexpressed in GDM HUVECs compared to normoglycemic controls. Gene set enrichment analysis showed in addition an enrichment of genes involved in angiogenesis and Notch signaling pathways in human endothelial cells from GDM patients. GDM HUVECs had a significantly higher wound healing capacity compared to normoglycemic controls. The PI3K/AKT/mTOR pathway was enriched in GDM HUVECs. GDM HUVECs displayed impaired activation of AKT and eNOS (expression and phosphorylation) after stimulation with insulin, suggesting a possible insulin resistance. Finally, subjecting HUVECs to high laminar shear stress or simvastatin treatment caused a reduction of FABP4 mRNA expression and an increase of eNOS expression, indicating potential therapeutic strategies to improve endothelial function. Conclusions: We provided evidence that FABP4 could be involved in fetal GDM-induced endothelial dysfunction. High laminar shear stress and medications activating eNOS signaling could protect the endothelium against the negative impact of FABP4 in GDM.

Abstract 4138348: Mechanical stress-mediated nuclear envelope damage promotes Aortic Valve Calcification through the ZBP1-RIPK3-NF-κB signaling axis

Methods and Results: We describe a comprehensive characterization of the AVICs nucleus landscape as determined by transmission electron microscopy (TEM) of samples obtained from CAVD patients. Turbulence led to nuclear envelope integrity lose in AVICs cultured in shear stress experiments, with three different fluid conditions [static (ST), laminar stress (LS), and oscillatory stress (OS)], indicated by Western blot and immunofluorescence (IF). Silencing lamin A/C (LMNA) through small interfering RNA (siRNA), accelerated nuclear envelope damage , as indicated by Western blot, qPCR, and immunofluorescence (IF). The formation of Z-DNA and its co-localization with Z-DNA binding protein (ZBP1) was observed due to the nuclear envelope damage by IF. Western blot, qPCR, IHC and IF confirmed Z-DNA-induced inflammation in AVICs through the ZBP1-RIPK3-NF-κB signaling pathway. ZBP1 and RIPK3 knockdown with siRNA markedly reduced the protein level of osteogenic markers alkaline phosphatase (ALP), runt-related transcription factor 2 (RUNX2), and bone morphogenetic protein 2 (BMP2) in VICs. In vivo, aortic valve disease was constructed by direct wire injury (DWI), and we showed that overexpression of LMNA by adeno-associated virus significantly decelerated the progression of aortic valve lesion induced by DWI in mice. Conclusion: Excessive mechanical stress can induce damage to the nuclear envelope of AVICs by causing cytoskeletal remodeling, initiating the formation of Z-DNA, and hastening the calcification process in AVICs and CAVD.

Abstract 4117646: The Ultimate Test in Hemocompatibility: HeartMate3 Restart After Prolonged Pump Shut Down

Introduction: The HeartMate 3 (HM3) LVAD, was shown to have a higher survival free of hemocompatibility related adverse events (HRAE) compared to its predecessors (HM2, HVAD). Superior HM3 outcomes are attributed to wide blood flow pathways coupled with frictionless movement and intrinsic pulsatility, reducing shear stress and blood stasis. It is unknown if improved hemocompatibility can withstand pump restart after prolonged shutdown. We herein report a case of HM3 pump stoppage without subsequent HRAE. Case Presentation: A 41-year-old male underwent HVAD implant in 2019 for advanced non-ischemic cardiomyopathy. This was exchanged to HM3 for recurrent neurological events despite therapeutic anticoagulation. Ten months after exchange, he awakened one morning to find his LVAD had been off for an unknown period but had not heard any device alarms (85dB if on battery power, 165dB if on wall power). Since he felt well he changed to battery power resulting in immediate pump restart. Log file analysis showed pump stoppage 2 am – 10 am, without preceding low flow alarms or power elevations. Management and Outcomes: In the ER INR was 1.5 (2.8 one week prior) and systemic heparin was started. Evaluation included: 1) CT brain without acute infarcts 2) echocardiogram without intracardiac thrombus 3) CT Angiography with patency of the inflow cannula and outflow graft 4) stable serial LDH measurements. The controller was exchanged, and analysis noted normal function. 1-year later the patient is maintained on warfarin and aspirin 325mg without further HRAE. Given the patient’s neurologic history and pump stoppage event, we did not invoke ARIES trial guidance and thus continued aspirin. Conclusion: Pump stoppage occurs when there is complete battery depletion, disconnection of both power leads, or the percutaneous lead from system controller. Our case is unique in that the duration of pump shutdown was 8 hours and INR subtherapeutic, without HRAE in the background of neurologic events on HVAD support. It has been previously reported that complete outflow graft thrombosis can occur shortly after LVAD decommissioning. The HM3 User Manual recommends restarting the pump immediately if off for a few minutes and using clinical judgment for longer durations due to increased risk for thromboembolic events. Our case adds to the paucity of existing data on improved hemocompatibility of the HM3 during rare circumstances of the ultimate test in hemocompatibility: complete pump shut down.

3D CFD analysis of pressure, boundary layer and shear stresses on a gudgeon (Gobio gobio)

The fish’s mechanosensory lateral line system detects non-acoustic hydrodynamic stimuli required for feeding, schooling, predator avoidance and underwater object detection. Biological investigations have established that flow stimuli are detected through the boundary layer as pressure gradients by canal neuromasts and as shear stresses acting on the superficial neuromasts. Previous works have also shown that the spatial distribution of neuromasts is strongly correlated with the pressure coefficient. Despite these fundamental insights, substantial knowledge gaps persist in understanding how fish body geometry influences the boundary layer, the pressure distribution and shear stresses. To address these gaps, we provide a set of numerical models based on the open-source CFD toolkit OpenFOAM which are experimentally validated using velocity measurements obtained in a laboratory fish swim tunnel. Specifically, we investigate the mid dorsal-ventral planar flow fields around a 3D fish-shaped body of gudgeon (Gobio gobio), a common freshwater bottom-dwelling fish. The contributions of this work are two-fold: First, we provide a comparison of the boundary layer thicknesses and velocity profiles at flow velocities ranging from 0.25 to 1.25 m/s. Second, we qualitatively compare the spatial distributions of the pressure coefficient, dynamic pressure and shear stresses to biological observations of the neuromast locations of adult gudgeon.

Impact of Geometric Attributes on Abdominal Aortic Aneurysm Rupture Risk: An InVivo FSI-Based Study.

Reported in this paper is a cutting-edge computational investigation into the influence of geometric characteristics on abdominal aortic aneurysm (AAA) rupture risk, beyond the traditional measure of maximum aneurysm diameter. A Comprehensive fluid-structure interaction (FSI) analysis was employed to assess risk factors in a range of patient scenarios, with the use of three-dimensional (3D) AAA models reconstructed from patient-specific aortic data and finite element method. Wall shear stress (WSS), and its derivatives such as time-averaged WSS (TAWSS), oscillatory shear index (OSI), relative residence time (RRT) and transverse WSS (transWSS) offer insights into the force dynamics acting on the AAA wall. Emphasis is placed on these WSS-based metrics and seven key geometric indices. By correlating these geometric discrepancies with biomechanical phenomena, this study highlights the novel and profound impact of geometry on risk prediction. This study demonstrates the necessity of a multidimensional assessment approach, future efforts should complement these findings with experimental validations for an applicable approach for clinical use.

Evaluation of the applicability of three sediment transport capacity equations on steep colluvial slopes and their modifications

AbstractAccurate estimations of the sediment transport capacity (Tc) are essential for soil erosion modelling. However, the applicability of existing Tc equations to colluvial soils with high steep slopes and high gravel content is limited. In this study, the variation of Tc with shear stress (τ), unit stream power (P) and stream power (ω) is investigated for different slopes and flow discharge. We also evaluate the applicability of the Yalin, Govers and GUEST equations (based on τ, P and ω, respectively) for estimating Tc on steep–slope colluvial deposits. Experiments were conducted using colluvial soil in a non‐erodible rill flume. The results reveal that Tc follows a power function with τ and ω and a linear function with P. The regression results of the three hydrodynamic parameters and Tc agree with the Tc equation forms of the corresponding equations. The Yalin equation, developed based on gently sloping erodible bed conditions, simulates overall low Tc values for steep sloping non‐erodible bed conditions (P.O.0.5–2 = 42.8%). The accuracy is significantly improved by correcting the sediment transport coefficient Kt (P.O.0.5–2 = 100%). The accuracy of the Govers‐simulated Tc values under steep slope conditions, based on gentle slope conditions, decreases with increasing slope gradient (P.O.0.5–2 = 37.14%), which is attributed to the large amount of coarse‐grained sediment present in this study. Thus, we retained the original form of the equation and further improved its accuracy by adjusting the coefficients (P.O.0.5–2 = 94.29%). As Tc increases, the GUEST equation can accurately simulate Tc. The accuracy is improved by calibrating the F‐value (P.O.0.5–2 = 100%). Using dimensional analysis, the equations built based on hydraulic conditions (excess current power, shear stress, flow velocity, etc.) and median particle size can accurately simulate Tc values (P.O.0.5–2 = 100%). These findings provide a basis for the development of erosion models for avalanche deposits on steep slopes.

Insights from Computational Fluid Dynamics and In Vitro Studies for Stent Protrusion in Iliac Vein: How Far Shall We Go?

These findings provide significant implications for the enhancement of iliac vein stent implantation strategies and stent design. The prevalent use of stents for treating Iliac Vein Compression Syndrome (IVCS) has shown efficacy, yet the associated clinical adverse events, including stent restenosis and postoperative thrombosis, are significant concerns. Up to now, the mechanism how the stent implantation induces the restenosis and DVT is still unclear. Our study hypothesizes that these adverse outcomes arise from altered blood flow dynamics following stent implantation. Employing computational modeling and medical imaging, we simulated IVCS after various stenting procedures to assess their impact on venous blood flow characteristics, including wall shear stress (WSS), residence time (RRT), and oscillatory shear index (OSI). Our findings reveal that a stent protruding into the vena cava impedes blood circulation, with increased protrusion exacerbating this obstruction. This is particularly evident at the vein bifurcation, where low WSS and elevated OSI and RRT are observed. Moreover, a higher stent strut density further obstructs blood flow, deteriorating the hemodynamic environment. Consequently, stent protrusion into the vena cava can enhance the likelihood of adverse post-surgical events. These insights have profound implications for optimizing iliac vein stent implantation techniques and stent design.

Simulation of blood flow in a tapered artery with ternary hybrid nanofluid and Jeffrey model

This research simulates flow of blood in a tapered peristaltic artery integrating ternary hybrid nanofluid using the Jeffrey fluid model. The simulation examines the effects of Au, Fe3O4, and Ag nanoparticles on the flow. The artery, modeled as a peristaltic channel, is subjected to nonlinear thermal radiation, magnetic forces, and heat source. The problem is formulated using non-linear Cartesian partial differential equations, which are then transformed into dimensionless form without approximations. Adomian Decomposition Method (ADM) is employed to solve these equations, revealing how normal and shear stress, normal and axial velocities, induced magnetic fields, and temperature profiles vary with changes in relevant parameters. Additionally, biological factors are considered to graph streamlines, providing a comprehensive analysis of the flow dynamics. Some notable results include that adding ternary nanoparticles increases the Nusselt number by 26.03% in Newtonian fluids and 158.69% in Jeffrey fluids, and increasing tapering parameters and wavenumber improves axial and normal velocities, heat transfer, and flow complexity.

Thermohydraulic Performance and Flow Structures of Diamond Pyramid Arrays

Abstract Surface features are a common heat transfer enhancement method used in a myriad of applications including gas turbines and heat exchangers. One such style of surface features are diamond pyramids, which offer significant heat transfer augmentation for moderate increases in overall pressure losses. This study investigated a suite of additively manufactured pyramids in a variety of sizes and arrangements at relevant scale contained in test coupons. Designs were printed with low surface roughness relative to typical additive components (Ra < 5µm), and pyramids were printed within 100 µm of the design intent. Experimental and computational results indicate that the pressure penalty and heat transfer increased as the pyramids increased in size with aligned pyramids on both channel walls having higher values than staggered pyramids. It was found that implementing the pyramids onto a rough surface had a lesser impact on the friction factor than implementing on a smooth surface, but that the relative increase in heat transfer was the same regardless of the roughness of the endwall. The greatest enhancement to local heat transfer and pressure loss was offset from the location of minimum flow area due to local acceleration around the wake regions. The vortices formed in the wake of the pyramid structures enhanced the endwall heat transfer and shear stress. The performance of the pyramids investigated in this study follows a similar trend to prior studies investigating smooth rib geometries, though certain rib designs had higher heat transfer at lower pressure losses.

A numerical investigation of the structural behavior of reinforced concrete beams fully or partially encased with UHPC layers in flexure

Weakness in the structural facilities appears due to design faults, poor construction, usage change, maintenance lack, material defects, and environmental conditions. Therefore, strengthening structures becomes necessary for deteriorated concrete and enhancing aging concrete elements to achieve satisfactory performance perfectly. This study numerically investigated the structural behavior of conventional concrete beams reinforced with Ultra-High Performance Concrete (UHPC) layers on different sides. The arrangement of UHPC layers, bonding method between traditional concrete and UHPC, layer thickness, and reinforcement ratio were examined using Abaqus software. The interface between the UHPC layer and conventional concrete sustains compressive, tensile, and shear stresses, which cause weak resistance to the stresses at the contact surfaces. Therefore, the simulation of contact face in Abaqus needs a proper numerical model relying on practical methods. However, using the bonding models available in Abaqus is crucial for reaching logical results comparable to the practical ones. The practical bonding approaches are highly consequential, such as roughening surfaces by sandblasting to attain a firm connection between the contact surfaces, which permits using a surface-based tie constraint for simulation. Further, epoxy resin conducts as a thin coating between contact surfaces, making it possible to simulate via a cohesive surface. The results proved that increasing the area encased by the UHPC layer improves load capacity further and reduces the deflection at the maximum load. Surrounding the beam on whole sides with a UHPC raises load capacity by 108 % and reduces deflection by 46 %. Adding a UHPC layer to the beam delays crack initiation and reduces their number and spacing. Increasing the UHPC layer thickness or reinforcement ratio enhances the load capacity of the beam at cracking and the ultimate state.

Nonlinear waves in a sheared liquid film on a horizontal plane at small Reynolds numbers

The nonlinear waves in a sheared liquid film on a horizontal plate at small Reynolds numbers are examined by theoretical and numerical approaches. The analysis employs the long-wave approximation along with finite difference schemes. The results show that the surface tension can suppress disturbances and prevent the occurrence of singularities. While the film flow is driven by the shear stress on the interface, its instability highly depends on the magnitude and direction of gravity. Specifically, when the direction of gravity is opposite to the wall-normal direction, perturbations are stabilized by gravity. In contrast, when these two directions are the same, the gravitational force is destabilizing, and stationary travelling waves can exist if a balance is reached between the effects of gravity and surface tension. For the steady solitary waves, there are quasi-periodic oscillations occurring between two stationary points, indicating the presence of heteroclinic trajectories. For periodic waves, the evolutions are sensitive to several parameters and initial disturbances, while one steady-state wave exhibits a sine function-like behaviour.

Dynamics of Viscous Jeffrey Fluid Flow Through Darcian Medium With Hall Current and Quadratic Buoyancy.

This contribution builds on existing studies by investigating the dynamics of Hall current in Jeffery fluid under radiative heat, convective boundary conditions, Joule heating, and Darcy dissipation. Hall current, an important phenomenon in engineering applications involving strong magnetic fields, highlights the impact of electromagnetic force in examining blood flow rate, determining charge drift velocity, density, and movement, and is used in power generators and high-voltage transformers. This analysis incorporates dissipative and thermal radiative heat and employs the effects of Hall current and Joule heating, resulting from porous medium resistance, to derive the partial differential equationsgoverning the dynamic systems. These equationsare then reduced to ordinary differential equations (ODEs) through similarity variables. The Galerkin weighted residual method (GWRM) is employed to examine the dynamics of Hall current and quadratic thermal buoyancy, shedding light on the thermal properties and hydrodynamics of Jeffrey fluid convection within a porous medium. The analysis reveals that in the presence of an applied magnetic field, the contribution of Hall current to flow and heat dynamics induces a magnetic force that enhances fluid motion and negatively impacts heat energy patterns. The imposition of dissipative heat physically increases the fluid temperature, owing to an increase in buoyancy current. The occurrence of thermal radiation, Hall current, viscous dissipation, and Joule heating can efficiently optimize the rate of heat transfer and shear stress. Moreover, the tabular results indicate that Jeffrey fluid, exhibiting higher relaxation time, will experience a lower friction coefficient and heat transferrate.