Wall Occlusion Research Articles

Scheme design of the optimal background clutter suppression for impulse radio ultrawide band radar in complex fire environment: a simulation and experimental study

Impulse radio ultrawide band (IR-UWB) radar possesses several advantages, such as heat flow insensitivity, high resolution, great penetration, good mobility, and lightweight, making it a promising technology for detecting and rescuing individuals trapped in fire scenarios. However, reliable detection and extraction of vital signs of trapped people in the presence of complex fire environment, such as water droplets, smoke, wall occlusions, and reflections, require an optimal background clutter suppression scheme designed specifically for fire scenarios. This study comprehensively evaluates 20 background noise suppression schemes using an exhaustive approach that involves constructing radar echo simulation signals and designing an evaluation method for algorithms. The practical applicability of the improved design solutions was evaluated by conducting small-scale fire experiments in an acrylic chamber. The results indicate that the designed scheme is effective in overcoming the background interference from the combustion environment and is capable of supporting subsequent trajectory identification and vital sign extraction in the fire scene environment.

Abstract 6206: Discerning vasculature destruction caused by novel vascular disrupting agents examined by optical and multispectral optoacoustic imaging

Abstract Tumor growth requires a functioning vascular network and offers an attractive therapeutic target. The invasive proliferating neovasculature of tumors lacks pericyte support and exhibits increased permeability thereby offering a unique, potentially selective target for anticancer therapy. Most vascular disrupting agents (VDAs) inhibit microtubule formation, causing rapid morphological changes in endothelia cells resulting in dramatically increased vessel permeability, cellular detachment, vessel occlusion, and vessel wall damage [doi: 10.3390/molecules26092551]. Highly vascular kidney tumors are expected to be particularly sensitive to VDAs. We are evaluating OXi8007, a water soluble indole phosphate pro-drug derivative of the first generation VDA combretastatin. The prodrug OXi8007 is stable in saline but releases active OXi8006 is the presence of alkaline phosphate. Preliminary pharmacokinetic data benchmarked using 13C-labeled OXi8006 and OXi8007 show rapid vascular clearance and conversion to the glucuronide conjugate in vivo. Doses up to 700 mg/kg were tolerated by mice. Luciferase-expressing RENCA tumor cells were implanted orthotopically in the right kidney capsule of syngeneic BALB/c mice. Bioluminescence Imaging (BLI) was applied weekly to assess tumor growth and acute response to OXi8007. Following addition of luciferin substrate subcutaneously BLI signal from the tumor reached a maximum within 10 minutes. When BLI was repeated 4 hrs after 250 or 350 mg/kg OXi8007 IP, the generated signal was <1% of baseline signal indicating acute vascular disruption. Multispectral Optoacoustic Tomography (MSOT) revealed matching acute changes in tumor vascular oxygenation and additionally showed distinct heterogeneity. An oxygen gas breathing challenge indicated lower oxygen saturation in the tumor following treatment. Histology showed massive hemorrhage following both doses. BLI signal recovered after 1 to 2 days and repeated administration of OXi8007 again caused acute vascular shutdown. These results match previous observations in breast tumor models [doi: 10.1016/j.canlet.2015.08.021] indicating opportunities for therapeutic application. Citation Format: Hashini I. Wanniarachchi, Regan Schuetze, Lorena Arango, Khagendra Hamal, Graham J. Carlson, Cyprian Pavlich, Yuling Deng, Mary L. Trawick, Kevin G. Pinney, Li Liu, Ralph P. Mason. Discerning vasculature destruction caused by novel vascular disrupting agents examined by optical and multispectral optoacoustic imaging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6206.

Recovering Human Pose and Shape From Through-the-Wall Radar Images

Although the through-the-wall radar imaging (TWRI) system working in the appropriate frequency band can penetrate the nonmetallic obstacles and sense the targets behind, its low imaging spatial resolution hinders the acquisition of more detailed information, such as human pose and shape. This article mainly discusses a deep learning-based human pose and shape recovery method from TWRI images. Inspired by cross-modal learning, the method follows a teacher–student learning pipeline that avoids the heavy cost of manual labeling. Specifically, a camera is attached to the self-develop radar system to simultaneously capture paired red-green-blue (RGB) images and TWRI images in a scenario without wall occlusion. A pose estimation framework (Hourglass) and a semantic segmentation framework (UNet) serve as the teacher network to convert the RGB images into the pose keypoints and the shape masks. By taking inspiration from the topological architecture of these frameworks, a student network radar pose shape network (RPSNet) is designed to extract the information from the corresponding radar images and predict the keypoints and masks that are close to the results above. Instead of learning two single-task objectives independently, multitasking learning is introduced to adaptatively learn common features. When applied to wall-occlusive scenarios, only the radar images are collected and fed into the student network for pose and shape recovery. The advantages of this method over computer vision-based methods for human recovery are demonstrated in scenarios both without and with wall occlusion.

Modelling the wetting of a solid occlusion by a liquid film

We investigate in this work how the presence of an occlusion affects the dynamics of the wetting front of a liquid film draining down a vertical surface. This numerical study is developed in the context of the lubrication approximation. Through a parametric study, we show that depending on the asymptotic film thickness and the fluid properties, there exists a critical substrate contact angle below which separation of the contact line from the occlusion wall is observed which results in the appearance of a dry zone in the wake of the occlusion. In analogy with external aerodynamics, we also show that a sharp corner in the occlusion can induce this contact line separation. Our numerical results also highlight the importance of the occlusion wettability on the morphology of the wetting front suggesting a possible mechanism to control and mitigate the often undesirable fingering instability.

Δ4-Ethyloestrenol in Recurrent Deep Venous Thrombosis

Twenty-one patients with recurrent deep venous thrombosis were treated with an anabolic steroid (Δ4-ethyloestrenol) for up to 56 months. All had been shown to have a deficient fibrinolytic response to vascular occlusion and/or low vessel wall plasminogen activator content. Therapy resulted in improvement in clinical and fibrinolytic parameters and no significant side effects were seen.

Observations on factors affecting local forces in the left ventricular wall during acute myocardial ischemia.

The factors affecting local myocardial function in the presence of ischemic myocardial damage may considerably influence cardiac function and the extent of tissue damage resulting from the initial ischemic injury. However, previous attempts to study local wall forces in the ischemic myocardium have produced variable results. In the present study, a technique was developed for recording isometric left ventricular wall tension that minimized artifacts due to external forces acting on the ischemic area. Miniature isometric force gauges were implanted in 23 dogs in the left ventricular wall within a zone buffered by two rows of transmural prongs attached to a ring. During a test occlusion of a branch of the left anterior descending coronary artery, the ischemic area was defined by the presence of epicardial ST segment elevation, and force gauges were implanted in marginal or ischemic areas of the myocardium. During a subsequent coronary occlusion wall force in the ischemic area fell immediately by an average of 31 ± 8%. When the occlusion was repeated during isoproterenol infusion, wall tension decreased in previously unaffected areas of the myocardium, although in ischemic areas it remained above previous control ischemic levels. Arterial counterpulsation improved the development of wall tension in the ischemic area by 27% and decreased the extent and amount of ST segment elevation. Thus the present study clearly indicates a significant reduction but not elimination of active myocardial wall force in ischemic zones following experimental coronary occlusion. Moreover, force could be augmented by either isoproterenol or counterpulsation, and counterpulsation can produce a significant improvement in function of the ischemic myocardium while reducing the area of ischemic injury.