Cavity Wall Research Articles

Undrained cavity expansion-contraction analysis in CASM and its application for pressuremeter tests

Many geotechnical scenarios involve cavity unloading from a loaded state, particularly in pressuremeter tests, and the unloading data of pressuremeter tests has exceptional attraction as it is less disturbed by the insertion process. However, the analyses for continuous cavity loading and unloading (i.e., cavity initially experiences expansion and then contracts) in critical state soils are rarely studied. To this end, a novel semi-analytical solution based on the unified state parameter model for clay and sand (CASM) is proposed for the whole expansion-contraction of spherical and cylindrical cavities under undrained condition. The problem assumes that the cavity is unloaded after a monotonic loading stage, leading to plastic regions during both loading and unloading periods. The cavity response for the whole expansion-contraction process is investigated, with the total pressure and stress paths at the cavity wall presented and validated against numerical simulation. The developed solution is successfully implemented to interpret both loading and unloading data of pressuremeter tests. The undrained shear strength, in-situ effective horizontal stress and initial overconsolidation ratio are back analyzed by using a curve fitting method based on the proposed solution.

Computational study of a helium-propellant microwave electrothermal thruster

The microwave electrothermal thruster (MET) utilizes wave-exited microdischarges to heat gas flows, enhancing the specific impulse of the thruster. Our computational study investigates a 17.5 GHz helium-propellant MET, employing a two-dimensional, axisymmetric fluid model of plasma coupled with electromagnetic wave and gas flows. The discharges operate in the glow regime, remaining weakly ionized, and in thermal non-equilibrium. The plasma densities reach approximately 1020m−3, and the gas temperature is around 2000 K. Even a slight off-resonant frequency operation results in a significantly lower plasma density and gas temperature. Gas heating, primarily driven by electromagnetic Joule heating, plays a critical role in influencing the overall discharge behavior. The measured peak thrust and specific impulse are 8.24 mN and 292 s, respectively, at a mass flow rate of 3.2 mg/s with 30 W of power. Compared to a cold gas thruster, there is a significant increase in the specific impulse by a factor of approximately 1.7. The enhanced performance trades off with propulsive efficiency, which decreases by a factor of 1.5 from the peak 65% at 10 W. This is due to higher energy losses to cavity walls from heat conduction with increased power. These findings underscore the critical balance between the input power and mass flow rate to improve the MET performance, highlighting the importance of power management to maximize thrust and efficiency. Furthermore, the predicted thrust and specific impulse agree well with experimental values for nominally similar MET thruster studies in the literature.

Abstract PO5-22-09: Positive pegulicianine fluorescence rate in the lumpectomy cavity correlates with tumor distance to margins in excised tissue

Abstract Title: Positive pegulicianine fluorescence rate in the lumpectomy cavity correlates with tumor distance to margins in excised tissue Background: A randomized, two-arm pivotal study of pegulicianine fluorescence guided surgery (pFGS) at 14 US sites was conducted using the Lumicell Direct Visualization System (DVS) to identify residual cancer in the lumpectomy cavity after the standard of care (SoC) tumor excision. We reported that the Lumicell DVS detects residual cancer in the lumpectomy cavity, including in orientations pathologically negative on the SoC specimen. In addition, 15% (9 of 62) of patients with positive SoC margins were converted to final negative margins by taking Lumicell DVS directed cavity margins, avoiding a second unnecessary surgery. Interestingly, 8 of these 9 patients had no tumor found in the Lumicell DVS guided specimens. We hypothesize that fluorescence decreases as the distance from the tumor boundary increases. We analyzed data from the pivotal study (NCT03686215) to assess correlation of pegulicianine signal with tumor-to-margin distance, and its potential clinical value. Methods: The pivotal study enrolled 406 patients undergoing breast conserving surgery (BCS) for stage 0-III breast cancers. Patients received an IV injection of pegulicianine 2-6 hours prior to surgery. After the standard of care lumpectomy was completed, additional Lumicell DVS-guided cavity margins were excised at sites of positive pegulicianine fluorescence signal in the lumpectomy cavity walls using a hand-held imaging device and patient-calibrated cancer detection software. The positive fluorescence rate, that is, the rate at which the Lumicell DVS indicates areas suspected to contain cancer, was calculated as the ratio of orientations with positive pegulicianine signal to the total number of orientations with (1) negative margins, (2) positive margins and (3) positive margins with ink on tumor, on the initial SoC lumpectomy specimen. Calculations were made on a per-margin basis. Positive margins were defined as ink on tumor for invasive cancer and tumor less than 2 mm from the margin for ductal carcinoma in situ (DCIS) alone. Results: Results are presented in Table 1. We found a statistically significant higher positive fluorescence rate in orientations with positive margins (p=0.044). The positive fluorescence rate was even higher (21.1%) when only considering cases with ink on tumor (a subset of the positive margin group). Discussion: By design, pegulicianine is activated by enzymes within the tumor and in stromal cells at the invasive front surrounding the tumor. Thus, when tumor is closer to the edge of the lumpectomy specimen, the rate of positive pegulicianine fluorescence in the cavity increases, being highest when there is tumor present at the inked margin. This feature of pegulicianine fluorescence guides the surgeon to resect more tissue in these areas in order to achieve a negative margin of the required width. The conversion of positive margins after the SoC lumpectomy to appropriately wide final negative margins prevents a second surgery, even when there is no tumor in the DVS guided margins. These findings have strengthened our understanding of the utility of this technology. Table 1 Positive cavity wall fluorescence rate for SoC lumpectomy positive margins, SoC lumpectomy negative margins and SoC lumpectomy ink on tumor margins Citation Format: Irene Wapnir, E Shelley Hwang, Kelly Hunt, David Carr, Peter Blumencranz, Manna Chang, Kate Smith, Jorge Ferrer, Barbara Smith. Positive pegulicianine fluorescence rate in the lumpectomy cavity correlates with tumor distance to margins in excised tissue [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-22-09.

Abstract PO4-11-12: Patient Reported Outcomes from a multi-site, prospective Pivotal study evaluating pegulicianine fluorescence guided surgery (pFGS) for breast cancer lumpectomy procedures using the Lumicell Direct Visualization System (DVS)

Abstract Background: In pegulicianine fluorescence guided surgery (pFGS), a standard of care lumpectomy procedure is performed, and additional tissue is taken from cavity walls at sites of high pFGS signal. This approach been shown to reduce 2nd surgeries and remove additional tumor left by standard surgery, but may remove more tissue, potentially worsening cosmetic outcomes. Patient breast satisfaction surveys were used to assess cosmesis after pFGS. Methods: A prospective Pivotal trial of pFGS in women undergoing lumpectomy surgery for stage 0-III breast cancer was conducted at 14 US sites (NCT03686215). We assessed the safety and efficacy of the Lumicell DVS in identifying and removing residual cancer from the lumpectomy cavity in real time. Patient Reported Outcome Measures (PROM) data was collected as an exploratory endpoint. The BREAST-Q, a validated tool that measures patient perspectives after different breast procedures, was used to collect PROM data. An 11-question BREAST-Q survey was used to measure patients’ breast satisfaction at baseline (pre-surgery) and at multiple timepoints through 6-months post lumpectomy. Descriptive statistics of participating patients’ responses were collected and analyzed. Survey results were analyzed by the distribution of patient ratings for each question and the change in the distribution of ratings over time, with comparison of baseline to post-lumpectomy. Comparison of patient satisfaction with or without additional pFGS-directed tissue removal was performed with Item Response Theory assuming all items equally discriminative of responding patients. For each timeframe, responses to BREAST-Q items were used to create a response score for each patient. Scaled factor scores (0-100) were compared between groups with and without additional tissue removed during pFGS. Results: Of the 357 patients evaluated for efficacy in the primary Pivotal study analysis, 255 patients agreed to participate in the PROM surveys (71%). Approximately 60% of the participating respondents completed a pre- and initial post-lumpectomy survey while only 34% of the participating patients completed a pre- and 6-month post-lumpectomy survey. Most patients responded either “Very Satisfied” or “Somewhat Satisfied” across all surveyed timeframes. No significant difference in patient breast satisfaction was found at any time point between the groups with and without additional pFGS-guided shaves removed (p >0.05). There were 4 patients with scores of 3 or higher pre-surgery but 2 or lower post-surgery. Among these, 1 had no pFGS-guided shaves taken. The remaining 3 had had pFGS-guided shaves taken, but 2 required a second lumpectomy surgery and 1 underwent mastectomy, these additional surgeries likely accounting for decreased cosmetic outcomes. Discussion: Patient perspective of breast satisfaction was not decreased by the amount of extra tissue removed by pFGS. These data suggest that pFGS using the Lumicell DVS does not significantly decrease breast cosmesis. Three of 4 patients with decreased satisfaction had 2nd surgeries, confirming the importance of finding approaches to decrease 2nd surgeries. This data was collected during the COVID-19 pandemic, which may have adversely impacted the compliance rate of survey completion. Studies in larger cohorts with longer follow up are required to better assess the relative impact of 2nd surgeries, radiation, and systemic therapy on breast satisfaction PROM scores after lumpectomy. Citation Format: Kelly Hunt, Irene Wapnir, E Shelley Hwang, David Carr, Peter Blumencranz, Kate Smith, Manna Chang, Jorge Ferrer, Barbara Smith. Patient Reported Outcomes from a multi-site, prospective Pivotal study evaluating pegulicianine fluorescence guided surgery (pFGS) for breast cancer lumpectomy procedures using the Lumicell Direct Visualization System (DVS) [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-11-12.

A methodology to evaluate the optimal insulation thickness for heating and cooling needs in different climatic zones for buildings made of reinforced concrete with cavity walls

The study aims to define a methodology to evaluate the optimal insulation thickness with reference to the annual energy balance, including both heating and cooling seasons, for different climatic zones, based on three real case studies. The reduction of the heating needs due to the insulation of walls in places with cold climates is a consolidated concept. However, the effects of a high level of insulation of the envelope on the cooling needs has not yet been deeply analysed.The heating and cooling needs have been computed according to UNI/TS 11300 Italian standard by means of a commercial numerical model, varying the sizes of the buildings, the climatic zone, and the level of insulation. All the simulations concern buildings made of reinforced concrete frames with cavity walls, because of their wide diffusion as typical building technology of post war constructions.The work highlights the negative impact of the coating on the cooling needs, especially in the climatic zones with lower degree days. In almost all the climatic zones, the cooling need decreases its peaks during the hottest months (e.g., July or August), while the monthly load increases in the mild months (e.g., May, September) due to the additional thermal load which is no longer dispersed by means of the envelope. In conclusion, a range of optimal thicknesses for insulation for the different Italian climatic zones has been identified based on the total energy need of the building (cooling and heating).

Numerical analysis of a gas flow in a square cavity driven by spanwise lid motion on the basis of kinetic theory: Behavior of the gas near a sharp corner

A gas flow in a square cavity driven by a lid sliding in the direction of its line of contact with the cavity wall is considered. The steady behavior of the gas is numerically investigated based on the linearized Bhatnagar–Gross–Krook kinetic equation and the diffuse reflection boundary condition. When one applies the Stokes equation and the no-slip boundary condition to the system considered here, the flow velocity becomes multivalued at the corner between the lid and the cavity wall, and the shear stress diverges at the corner inversely proportionally to the distance from there, which is known as the so-called corner singularity. In the present work, the behavior of the gas near the corner is examined based on numerical results obtained from the kinetic theory. Although the range of the flow velocity value in the kinetic solution is limited due to the significant velocity slip near the corner, the flow velocity is, nevertheless, multivalued at the corner. The shear stress varies inversely proportionally to the distance from the corner up to the position that is a few tens of mean free paths away from there. The increase in the stress is suppressed at positions closer to the corner and its magnitude remains bounded. Thus, the total forces acting on the lid and the side cavity walls are bounded as well. Due to the distinctive behavior of the stress near the corner, the resulting nondimensional total forces behave with an unconventional rate Kn ln Kn for small Knudsen numbers Kn.

Are man-made hives valid thermal surrogates for natural honey bee nests (Apismellifera)?

Honey bees preferentially occupy thick walled tall narrow tree cavities and attach their combs directly to the nest wall, leaving periodic gaps. However, academic research and beekeeping are conducted in squat, thin walled man made hives, with a continuous gap between the combs and the walls and roof. Utilising a computational fluid dynamics (CFD) model of thermoregulating bees in complete nests in trees and thin walled man made hives, with the average size of tree comb gaps determined from honey bee occupied synthetic tree nests, this research compared the metabolic energy impacts of comb gaps and vertical movement of the thermoregulated brood area. This shows their heat transfer regimes are disparate, including: bee space above combs increases heat loss by up to ∼70%; hives, compared to tree nests, require at least 150% the density of honey bees to arrest convection across the brood area. Tree cavities have a larger vertical freedom, a greater thermal resistance and can make dense clustering redundant. With the thermal environment being critical to honey bees, the magnitude and scope of these differences suggest that some hive based behavioural research needs extra validation to be considered non-anthropogenic, and some bee keeping practices are sub-optimal.

Prototype of a 2.45 GHz cylindrical ceramic dielectric antenna surface wave plasma source for flood gun

In modern ion implanters, plasma flood gun (PFG) is used to neutralize wafer charge during doping process, preventing the breakdown damage of floating wafers caused by the space charge accumulation. Surface wave (SW) plasma source is a potential choice for PFG, because of its no metal pollution, simple structure, high current intensity and low cost for ion implanters. At Peking University (PKU), a 2.45 GHz surface wave PFG (SW-PFG) with a cylindrical dielectric antenna was designed and tested recently. It aims to obtain plasma at the gas pressure of several 10−3 Pa and below which is strictly required by the ion implanter. A two-dimensional discharge model was established to optimize the cylindrical dielectric antenna structure. Through optimization of operation parameters, the electron current intensity of 88 mA was obtained with RF power 500 W and gas pressure 5.0 × 10−3 Pa in the experiments, which meets the requirement of ion implanters. Further, through optimization of operation parameters, the electron current intensity could reach 140 mA. In addition, by setting the graphite liner to isolate the metal cavity wall and plasma, the improvement in the long-term operation stability has been confirmed, which laid a solid foundation for the industrial application of the SW-PFG.

The first composite increment: Dependency on placement technique for interaction behavior with maturing dentin-adhesive bond at pulpal floors in deep occlusal cavities – A comprehensive review

Abstract Introduction: When the traditional incremental technique is used for direct placement of composite resin in a deep occlusal cavity, each increment (2 mm or thicker) is individually cured where it undergoes hardening and shrinkage. As increments are bonded to all cavity walls, a constrained shrinkage develops in tooth, composite, and/or interfaces. In the first composite increment, this constrained shrinkage generates tensile stresses which are distributed in a nonuniform pattern within that increment, resulting in premature stressing of the dentin bond of the hybrid layer at the pulpal floor before it reaches full maturation. This premature stressing leads to initiation of interfacial debonding and propagation to form a microgap. This behavior is associated with persistent postoperative sensitivity and tooth pain, over the time, which subsequently results in restoration failure. Aims: This paper provides a comprehensive review on the first composite increment and its dependency on placement technique for the interaction behavior with the maturing dentin-adhesive bond at pulpal floors in deep occlusal cavities. Materials and Methods: The dental database was searched, and 59 articles were collected and included in this review, spanning the years from 1984 to 2023. Results and Discussion: Three biomimetic direct restorative techniques were reported in the literature for incrementally restoring large occlusal cavities. These techniques are the decoupling with time, the decoupling with fiber, and the decoupling with split-increment. They all aim at minimizing the generated shrinkage stresses in the first composite increment for protecting the developing dentin bond of the hybrid layer until it reaches full maturation and thus preventing the initiation and propagation of interfacial defects at pulpal floors of deep occlusal cavities. Finally, the restoration is completed by placing and curing successive increments of 1.5 mm each to fill the cavity; their number depends on the cavity depth. These increments can each be cured immediately following placement. Conclusions: In deep occlusal cavities, the interaction behavior between the first composite increment and the maturing dentin-adhesive bond at the pulpal floor depends on the technique used for the increment placement. This behavior is either favorable with the direct biomimetic techniques or unfavorable with the traditional incremental technique. With the direct biomimetic techniques, no premature shrinkage stressing of the dentin bond is induced at the pulpal floor. This prevents the initiation of interfacial debonding and propagation to form microgaps and results in the absence of postoperative sensitivity and persistent tooth pain.

Mineral‐based Composite Phase Change Materials Assembled into 3D Ordered Aerogels for Efficient Wearable Filtration and Thermal Management

AbstractThe emerging concept of aerogel composite phase change materials (PCMs) represents a promising approach for thermal energy storage and utilization. However, the thermal storage aerogels currently reported usually lack essential aerogel properties, thereby constraining their potential for functional design and advanced applications. Herein, multifunctional thermal storage aerogels with aerogel characteristics and thermoregulation performance are prepared by chemically crosslinking and unidirectional freezing to make functionalized mineral‐based composite PCMs as cavity walls. Thanks to the cross–linked continuous skeleton and retained hierarchical porous, this novel thermal storage aerogel possesses an 89.7% porosity and demonstrates excellent resilience under 80% compression. As the PCMs in the cavity walls can convert phonon transport modes through phase transitions, the thermal storage aerogel has enhanced thermal insulation properties, reaching a thermal conductivity of 29.6 mW m−1 K−1. Drawing upon the multifunctional properties of thermal storage aerogels, it is demonstrated that thermal storage masks with thermal comfort and health protection, as well as passive thermal management wrist guards capable of harnessing solar radiation for temperature regulation. This work encompasses the exploration of novel approaches in developing advanced thermal management materials to cater to the diverse thermal regulation requirements of PCMs across various domains.

Investigating Protostellar Accretion-driven Outflows across the Mass Spectrum: JWST NIRSpec Integral Field Unit 3–5 μm Spectral Mapping of Five Young Protostars

Investigating Protostellar Accretion is a Cycle 1 JWST program using the NIRSpec+MIRI integral field units to obtain 2.9–28 μm spectral cubes of five young protostars with luminosities of 0.2–10,000 L ⊙ in their primary accretion phase. This paper introduces the NIRSpec 2.9–5.3 μm data of the inner 840–9000 au with spatial resolutions from 28 to 300 au. The spectra show rising continuum emission; deep ice absorption; emission from H2, H i, and [Fe ii]; and the CO fundamental series in emission and absorption. Maps of the continuum emission show scattered light cavities for all five protostars. In the cavities, collimated jets are detected in [Fe ii] for the four <320 L ⊙ protostars, two of which are additionally traced in Brα. Knots of [Fe ii] emission are detected toward the most luminous protostar, and knots of [Fe ii] emission with dynamical times of <30 yr are found in the jets of the others. While only one jet is traced in H2, knots of H2 and CO are detected in the jets of four protostars. H2 is seen extending through the cavities, showing that they are filled by warm molecular gas. Bright H2 emission is seen along the walls of a single cavity, while in three cavities narrow shells of H2 emission are found, one of which has an [Fe ii] knot at its apex. These data show cavities containing collimated jets traced in atomic/ionic gas surrounded by warm molecular gas in a wide-angle wind and/or gas accelerated by bow shocks in the jets.

Marginal integrity in minimally invasive molar resin composite restorations: Impact of polymerization shrinkage

ObjectivesThis study utilized non-linear finite element (FE) models to explore polymerization shrinkage and its impact on marginal integrity in molars following both selective caries removal (SCR) and conventional treatment. Specifically, we performed 2D in silico simulations to study residual stresses post-resin polymerization shrinkage and their influence on the marginal integrity of various restoration types. MethodsInitially, FE models were developed based on a cohesive zone framework to simulate crack propagation along the bonded interfaces between restoration and tooth structure in SCR-treated molars with class I and class II restorations. The modeled resin composite restorations first underwent polymerization shrinkage and were then subjected to various occlusal loading conditions. Stress magnitudes and distributions were identified to evaluate the margin integrity and predict the mechanism and location of interfacial failure. Results and discussionThe FE models computed polymerization shrinkage stresses of less than 1 MPa, exerting a minor influence on the composite/tooth interface. Occlusal loading, however, significantly impacted the load-bearing capacity of the composite/tooth (c/t) interface, potentially jeopardizing the restoration integrity. Especially under bi-axial occlusal loading, interfacial debonding occurred in the vertical cavity walls of the class I restorations, increasing the risk of failure. Notably, SCR-treated teeth exhibited better margin integrity than restored teeth after complete caries removal (NCR).These findings provide valuable insights into the mechanical behavior of SCR-treated teeth under different loading conditions and highlight the importance of considering the load scenarios that may lead to failure at the c/t interface. By investigating the factors influencing crack initiation and delamination, this novel research contributes to the optimization of restorative treatments and aids in the design of more resilient dental restorations.

Mixed convection heat transfer in a partial porous layered split lid-driven wavy wall cavity with Cu–H2O nanofluid

This numerical study investigates mixed convection heat transfer in a two-dimensional irregularly-shaped enclosure with a nanofluid-saturated porous medium. The enclosure has wavy vertical walls, a centered triangular block, and a lid split into two regions moving in opposite directions. Transport equations are solved using the finite element method under varied Darcy (10−5 to 10−1), Reynolds (50 to 200), Richardson (0.1 to 10), amplitude (0 to 0.2), and nanoparticle volume fraction (0 to 0.1) numbers. Results demonstrate the combined effects of forced convection from lid motion and natural convection from temperature differences significantly enhance heat transfer. The wavy walls induce secondary flows and periodic disruption of thermal boundary layers. Increasing Darcy number enables deeper penetration into the porous block. Copper nanoparticles incrementally improve conductive heat transfer. Richardson number effects are more prominent at higher Reynolds numbers as buoyancy forces influence vertical convection. This study provides novel insights into synergistically utilizing wavy geometries, nanofluids, porous media, and active pumping for optimizing heat transfer in irregular enclosures for electronics cooling and thermal management.

Endoscopic Balloon Dilatation of the Eustachian Tube via the Soft Palate Approach in Miniature Pigs.

The eustachian tube (ET) is one of the most complex organs in the human body, and its dysfunction may lead to a variety of diseases. In recent years, an increasing number of scholars have opted to conduct ET-related studies using large experimental animals such as miniature pigs or sheep, yielding promising results. Typically, conventional endoscopic procedures are performed through the nasal approach for large experimental animals. However, due to the elongated and narrow nasal cavity in these animals, transnasal surgeries are challenging. To address this issue, we explored an ET surgery approach via the soft palate. The animal was placed in a supine position. After endotracheal intubation under general anesthesia, a mouth opener was used to fully expose the upper palate. Local infiltration with diluted adrenal fluid was performed for anesthesia of the area. A sickle knife was then used to make a longitudinal soft palate incision at the junction of the soft and hard palates. After hemostasis, an endoscope was inserted into the nasopharynx cavity, allowing the visualization of the pharyngeal opening of the ET on the posterior lateral wall of the nasal cavity. Subsequently, a specialized pusher was used to insert a balloon into ET. The balloon was inflated, maintained at 10 bar for 2 min, and then removed. The incision in the soft palate was then sutured to ensure proper alignment. The soft palate healed well after the operation. This surgical approach is suitable for ET-related procedures in large experimental animals (e.g., miniature pigs, sheep, and dogs). The surgical procedure is simple, with a short surgical time, and wound healing is rapid. Under endoscopy, the pharyngeal opening of the ET is visible, and it is thus a good choice for procedures such as balloon dilation of the ET.

Transversely solar-pumped fiber laser with parabolic trough

We studied transversely solar-pumped Nd3+ doped fiber laser with parabolic trough via simulation models developed by Monte Carlo photon tracing method. Our analysis involved estimating losses at cavity walls and the absorption efficiency within the fiber core. Factoring in the absorption distribution of pumped solar radiation in the fiber, we determined an absorption efficiency of 8% for a 287 meter long fiber arranged in a semicircular configuration. Subsequently, our calculations found a laser output of 3.03 W for this fiber laser system, resulting in an overall conversion efficiency of 4.29% from solar to laser beam.

Heritability and predictive ability for the heterobothriosis resistance and growth performance in the tiger pufferfish Takifugu rubripes fed standard or low fishmeal diets

Heterobothriosis resistance and high growth performance are major concerns in the tiger pufferfish (Takifugu rubripes) farming. Our previous small-scale study suggested the feasibility of genomic selection (GS) for these traits but also identified an undesired genetic correlation between them, which could hamper simultaneous genetic improvement. Here, we sought to validate these initial findings through larger samples and crosses and also explore the potential of GS for the individuals fed a normal fishmeal diet and a low fishmeal (LFM) diet. We produced three populations: one was fed a normal diet (PopFM: 1100 individuals) and two were fed an LFM diet (PopLFM1: 993 individuals; PopLFM2: 1017 individuals); all three populations were artificially infected with Heterobothrium okamotoi, a monogenean parasite causing heterobothriosis. We recorded standard lengths of the fish after artificial infection (SLEAI) and the number of parasites on the gill cavity wall (HC) and genotyped genome-wide single nucleotide polymorphisms (SNPs) using genotyping by random amplicon sequencing, direct (GRAS-Di) technology for each sample: PopFM, 12 K SNPs; PopLFM1, 19 K SNPs; PopLFM2, 21 K SNPs. Heritability and prediction ability for each trait were estimated for each population using genomic best linear unbiased prediction (GBLUP), Bayes C, and Bayesian ridge regression methods. SNP effects on each trait were estimated by Bayes C, Bayesian ridge regression, and genome-wide association analyses (GWAS) using the same data sets. We observed moderate to high levels of heritability for HC (0.16–0.57) and SLEAI (0.50–0.77), with predictive ability of 0.25–0.55 for HC and of 0.51–0.73 for SLEAI. These values were slightly larger in LFM diet groups. As reported previously, a weak undesired genetic correlation was observed between the traits, and the correlation was more pronounced in the LFM groups. In conclusion, our results indicate that genetic gain in growth and parasite resistance traits can be expected for the tiger pufferfish through GS, especially for individuals reared on an LFM diet. However, close attention should be paid to the extent of the undesirable genetic correlation between the two traits that may be amplified in the populations fed an LFM diet.

Methodology of a thermal injection mold design with locally applied heating coatings on the cavity wall

AbstractThe thermal balance of injection molds is defined by the cooling channel layout. However, the fluid tempering of injection molds underlies certain restrictions concerning the thermal dynamic and the local limitation of the zone of influence. The optimal heat balance within the mold to minimize warpage cannot be solely achieved with conformal cooling channels. Ceramic heating coating systems applied by Thermal Spraying on the cavity wall are a novel tempering method for high heating rates and offer the possibility of a more local heat input. In terms of the thermal mold design, the position and size of local heating coating systems need to be determined. A methodology is proposed, which connects the optimization of part warpage by defining the necessary local heat flux within the mold with the determination of the heating coating placement. Due to the dependence of the coating placement on the heating time and the power, different decision criteria of these parameters are discussed with regard to the process efficiency. The developed methodology can calculate the necessary heating power distribution to homogenize the surface temperature and freeze time. A second step discretizes the heating power distribution to certain manufacturable heating zones.

FAUST

Context. The origin of the chemical diversity observed around low-mass protostars probably resides in the earliest history of these systems. Aims. We aim to investigate the impact of protostellar feedback on the chemistry and grain growth in the circumstellar medium of multiple stellar systems. Methods. In the context of the ALMA Large Program FAUST, we present high-resolution (50 au) observations of CH3OH, H2CO, and SiO and continuum emission at 1.3 mm and 3 mm towards the Corona Australis star cluster. Results. Methanol emission reveals an arc-like structure at ∼1800 au from the protostellar system IRS7B along the direction perpendicular to the major axis of the disc. The arc is located at the edge of two elongated continuum structures that define a cone emerging from IRS7B. The region inside the cone is probed by H2CO, while the eastern wall of the arc shows bright emission in SiO, a typical shock tracer. Taking into account the association with a previously detected radio jet imaged with JVLA at 6 cm, the molecular arc reveals for the first time a bow shock driven by IRS7B and a two-sided dust cavity opened by the mass-loss process. For each cavity wall, we derive an average H2 column density of ∼7 × 1021 cm−2, a mass of ∼9 × 10−3 M⊙, and a lower limit on the dust spectral index of 1.4. Conclusions. These observations provide the first evidence of a shock and a conical dust cavity opened by the jet driven by IRS7B, with important implications for the chemical enrichment and grain growth in the envelope of Solar System analogues.

Shock waves at final stages of cavity collapse in non-homogeneous liquid with divergenceless flow

We show the emergence of shock waves at the final stages of the complete collapse of a spherical cavity in a liquid with a smoothly decreasing density. The well-known Rayleigh assumption of fluid homogeneity is altered, while maintaining that of divergenceless flow. The fundamental difference between both infinite liquids is that his has an infinite mass, while ours, a finite one. Given the ease of deformation of non-homogeneous media in relation to homogeneous ones, as observed in several materials, all Rayleigh results are modified, including the cavity wall speed and acceleration, total time of complete collapse, and distribution of pressure in the infinite liquid. Rather than the homogeneous Rayleigh fluid, our non-homogeneous liquid can support a finite local sound speed. As a result, we succeed to show the emergence of shock patterns at the final stages of the cavity collapse. The analytical formulation is compared with underwater implosion and explosion experiments and simulations. Possible applications as a benchmark test for hydrocodes are briefly discussed.

Reactive Oxygen Species Explicit dosimetry for Pleural PDT

SignificancePreclinical studies show improved prediction of treatment outcome using [ROS]rx than light fluence rate or PDT dose. We demonstrate ROSED in a clinical setting. ApproachExplicit dosimetry of light fluence, photosensitizer concentration, and oxygen concentration is used to quantify the reactive oxygen species explicit dosimetry (ROSED) during Photofrin-mediated pleural PDT. Light fluence and photosensitizer concentration were measured by a customized multi-channel PDT dose dosimeter system. Diffuse correlation spectroscopy (DCS) contact probes were sutured to the pleural cavity wall after surgical resection of pleural mesothelioma tumor to monitor tissue blood flow (BFI) during intraoperative PDT treatment. Tissue oxygen concentration can be determined by utilizing tumor blood flow measured by DCS. ResultsLarge inter- and intra-patient heterogeneities in [ROS]rx were observed although an identical light dose of 60 J/cm2 was prescribed to all patients. ConclusionsThis study summarizes the current results of ROSED for a Phase II pleural PDT clinical trial.