Objective To identify and analyze the problems existing in nurses' daily use of 3-Minute Diagnostic Interview for CAM-Defined Delirium (3D-CAM) and to provide a basis for intelligent development of 3D-CAM. Methods From May to June 2018, totally 17 nurses who used printed 3D-CAM for daily evaluation of delirium in the Department of Orthopedics with a high incidence of delirium in a Class Ⅲ Grade A hospital in Beijing were selected by convenient sampling. Researchers observed and recorded the problems in nurses' daily use of 3D-CAM by task-centered walkthrough method till no new problems were found, i.e., the data were saturated and the data collection was completed. Results The 17 orthopedic nurses used printed 3D-CAM for 107 evaluations of 57 patients. According to the walk-through research, it was found that the main causes of misuse of 3D-CAM were man-made errors (n=30) , misunderstanding of items (n=7) , insufficient understanding of items (n=30) , and incomplete/missing nursing records (n=6) . Conclusions Nurses' use of printed 3D-CAM for delirium evaluation showed a high error rate and poor availability. Therefore, we need to enhance the training of delirium evaluation for nurses, conduct intelligent design and development of 3D-CAM and other delirium evaluation tools, and integrate them into the information system of hospitals so as to achieve the informatization, normalization and standardization of delirium evaluation. Key words: Nurses; Delirium; Evaluation; Problem analysis; Intelligent