Walk-off compensation using wedged cut type-II LBO was investigated theoretically and experimentally. An algorithm is proposed to find the optimized wedged cut angle to compensate the walk-off effect completely. Using a pulsed Nd:Y V O4 MOPA laser as the fundamental frequency infrared (IR) source, 36.3 W 355 nm frequency converted ultraviolet (UV) light was obtained using an optimized wedged cut type-II LBO for walk-off compensated third-harmonic generation (THG), giving a conversion efficiency of 37.1% from IR to UV. A comparative experiment using a conventional cut type-II LBO was also implemented. The results indicate that optimized wedged cutting of type-II LBO is an effective approach for walk-off compensation in efficient THG. The output performance of angle and temperature tuning for wedged cut type-II LBO was also investigated.