Transmutation of burnup products for a typical VVER-1000 reactor in a fusion-fission hybrid reactor has been investigated using MCNPX 2.6.0 calculation code. Burnup calculation of a fission reactor was performed for a 1000 MW practical power of a VVER reactor core using UO2 fuel and light water as its coolant and moderator, as well. The burnup products have been classified and separated according to their half-lives and their usages, and the remaining wastes were used as fuels for a fusion-fission hybrid reactor. The burnup calculation was also implemented for the fission wastes of the mentioned hybrid reactor, and the remaining products were separated and classified. The results showed that fission products can be transmuted into useful elements or to elements with less toxicity (with the decrement of activity) and less mass, and according to the IAEA toxicity limit of nuclear wastes, the levels of radioactivity and toxicity decreased. The results confirmed appropriately “the waste transmutation capability” of a fusion-fission hybrid reactor.